PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 15400
Common NameMICPUCDRAFT_15400
Organism
Micromonas pusilla CCMP1545
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae; Mamiellales; Mamiellaceae; Micromonas; Micromonas pusilla
Family C3H
Protein Properties Length: 482aa    MW: 51847.5 Da    PI: 8.6144
Description C3H family protein
Gene Model
Gene Model ID Type Source Coding Sequence
15400genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-CCCH28.23.3e-09451477127
              --S---SGGGGTS--TTTTT-SS-SSS CS
  zf-CCCH   1 yktelCrffartGtCkyGdrCkFaHgp 27 
              +++++C f+ +tG Ck+G +CkF+H+p
    15400 451 PGQPECVFYVKTGRCKFGHTCKFHHPP 477
              5789*********************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5001131.0571228IPR000719Protein kinase domain
SMARTSM002202.9E-271228IPR000719Protein kinase domain
Gene3DG3DSA:3.30.200.204.3E-12584No hitNo description
SuperFamilySSF561126.7E-485233IPR011009Protein kinase-like domain
PfamPF000691.3E-306226IPR000719Protein kinase domain
Gene3DG3DSA:1.10.510.101.1E-3685238No hitNo description
PROSITE patternPS00108090102IPR008271Serine/threonine-protein kinase, active site
PROSITE profilePS5139235.748231365IPR010513KEN domain
CDDcd104225.64E-52232363No hitNo description
PfamPF064798.3E-39234363IPR010513KEN domain
SMARTSM005803.2E-16296350IPR018997PUB domain
SMARTSM003565.9E-5450477IPR000571Zinc finger, CCCH-type
PROSITE profilePS5010314.464450478IPR000571Zinc finger, CCCH-type
PfamPF006425.1E-6452477IPR000571Zinc finger, CCCH-type
SuperFamilySSF902291.96E-5452476IPR000571Zinc finger, CCCH-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006397Biological ProcessmRNA processing
GO:0006987Biological Processactivation of signaling protein activity involved in unfolded protein response
GO:0008380Biological ProcessRNA splicing
GO:0009751Biological Processresponse to salicylic acid
GO:0009816Biological Processdefense response to bacterium, incompatible interaction
GO:0046777Biological Processprotein autophosphorylation
GO:0090501Biological ProcessRNA phosphodiester bond hydrolysis
GO:0042406Cellular Componentextrinsic component of endoplasmic reticulum membrane
GO:0004521Molecular Functionendoribonuclease activity
GO:0004672Molecular Functionprotein kinase activity
GO:0005524Molecular FunctionATP binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 482 aa     Download sequence    Send to blast
EGALDGRPVA VKRLLLQFYE LARKELATLI ASDEHPNVVR CYALEEDADF VYVALERCAS  60
TLAALGPTRA GLRIMRDACA GLHALHARGI VHRDLKPQNV LVTAAFRGKL ADMGLAKRLN  120
LTEGTTGDDR GGGGGGTSGW IAPERLLHGR QARSVDAFSL GCLLHFCLTG GGHPFGERYE  180
RDARVLRGDH DLRALDHLPE ARDLVSSLIR ADPAARPTTS EVLLHPMWWS RETRLGFLND  240
VSDRVEMEDR EKGGHLLLAE LDRGSWRGAL GGKEWTSRLP AGLLDNLGKY RSYDGRALRD  300
LLRVIRNKSN HYRELPKKIQ DEVGSYPDGM YDYFARKFPG LLLHAYRFAK DNCAHEPEFR  360
KFFFPSDDGG GGGGDTPDGG GGGGGGRIDG GSGVGGGGIG GGGGIGGGGD GATSASLERA  420
ARKAASRSQK RAAERAAVID ATPPVTYPSR PGQPECVFYV KTGRCKFGHT CKFHHPPGIH  480
D*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3fbv_B2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_C2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_D2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_E2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_F2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_G2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_H2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_I2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_J2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_K2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_L2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_M2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3fbv_N2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_A2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_B2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_C2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_D2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_E2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_F2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
3sdm_G2e-89136452447Serine/threonine-protein kinase/endoribonuclease IRE1
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtSenses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses. {ECO:0000269|PubMed:11706177, ECO:0000269|PubMed:12020828, ECO:0000269|PubMed:21914012, ECO:0000269|PubMed:22355548, ECO:0000269|PubMed:22359644}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By ER stress inducer tunicamycin, by salicylic acid (SA) and by bacterial pathogen infection.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003056997.10.0predicted protein, partial
SwissprotQ9C5S21e-110IRE1A_ARATH; Serine/threonine-protein kinase/endoribonuclease IRE1a
TrEMBLC1MMW00.0C1MMW0_MICPC; Predicted protein (Fragment)
STRINGXP_003056997.10.0(Micromonas pusilla)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
ChlorophytaeOGCP28241112
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G12020.25e-15WRKY family protein
Publications ? help Back to Top
  1. Koizumi N, et al.
    Molecular characterization of two Arabidopsis Ire1 homologs, endoplasmic reticulum-located transmembrane protein kinases.
    Plant Physiol., 2001. 127(3): p. 949-62
    [PMID:11706177]
  2. Noh SJ,Kwon CS,Chung WI
    Characterization of two homologs of Ire1p, a kinase/endoribonuclease in yeast, in Arabidopsis thaliana.
    Biochim. Biophys. Acta, 2002. 1575(1-3): p. 130-4
    [PMID:12020828]
  3. Braz AS,Finnegan J,Waterhouse P,Margis R
    A plant orthologue of RNase L inhibitor (RLI) is induced in plants showing RNA interference.
    J. Mol. Evol., 2004. 59(1): p. 20-30
    [PMID:15383904]
  4. Heazlewood JL,Tonti-Filippini J,Verboom RE,Millar AH
    Combining experimental and predicted datasets for determination of the subcellular location of proteins in Arabidopsis.
    Plant Physiol., 2005. 139(2): p. 598-609
    [PMID:16219920]
  5. Worden AZ, et al.
    Green evolution and dynamic adaptations revealed by genomes of the marine picoeukaryotes Micromonas.
    Science, 2009. 324(5924): p. 268-72
    [PMID:19359590]
  6. Chen Y,Brandizzi F
    AtIRE1A/AtIRE1B and AGB1 independently control two essential unfolded protein response pathways in Arabidopsis.
    Plant J., 2012. 69(2): p. 266-77
    [PMID:21914012]
  7. Deng Y,Srivastava R,Howell SH
    Protein kinase and ribonuclease domains of IRE1 confer stress tolerance, vegetative growth, and reproductive development in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(48): p. 19633-8
    [PMID:24145452]
  8. Chen Y, et al.
    Inter-regulation of the unfolded protein response and auxin signaling.
    Plant J., 2014. 77(1): p. 97-107
    [PMID:24180465]
  9. Parra-Rojas J,Moreno AA,Mitina I,Orellana A
    The dynamic of the splicing of bZIP60 and the proteins encoded by the spliced and unspliced mRNAs reveals some unique features during the activation of UPR in Arabidopsis thaliana.
    PLoS ONE, 2015. 10(4): p. e0122936
    [PMID:25860807]
  10. Deng Y, et al.
    IRE1, a component of the unfolded protein response signaling pathway, protects pollen development in Arabidopsis from heat stress.
    Plant J., 2016. 88(2): p. 193-204
    [PMID:27304577]
  11. Gaguancela OA, et al.
    The IRE1/bZIP60 Pathway and Bax Inhibitor 1 Suppress Systemic Accumulation of Potyviruses and Potexviruses in Arabidopsis and Nicotiana benthamiana Plants.
    Mol. Plant Microbe Interact., 2016. 29(10): p. 750-766
    [PMID:27578623]
  12. Meng Z,Ruberti C,Gong Z,Brandizzi F
    CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses.
    Plant J., 2017. 89(3): p. 486-501
    [PMID:27747970]