PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

29822.m003421

Common Name

RCOM_0852770

Organism

Ricinus communis

Taxonomic ID

3988

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae; Ricinus

Family

E2F/DP

Protein Properties

Length: 328aa MW: 36572.9 Da PI: 8.6338

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
29822.m003421	genome	JCVI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	75.1	7.4e-24	19	84	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rkeksL++l++kfl+l++k + + l+++a++L v +rRRiYD++N+Le+++++++k+kn+++wkg 29822.m003421 19 RKEKSLGVLCTKFLRLYNKDGVESIGLDDAATKL---GV--ERRRIYDVVNILESVGVVARKQKNQYSWKG 84 79***************999********.....****************************98 PP
2	E2F_TDP	70.7	1.7e-22	146	213	2	64
E2F_TDP 2 keksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliekkek 64 +eksL+lltq+f+kl+ +s +++tl+++a +L+ + +++k+RR+YDi+NV++++nliek+++ 29822.m003421 146 REKSLWLLTQNFVKLFLCSGVNMITLDSAAMSLLGDsltstAMRTKVRRLYDIANVFSSMNLIEKRNR 213 79***************************************************************654 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.1E-26	17	86	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.17E-15	19	82	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.6E-26	19	84	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.1E-20	20	84	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	2.4E-19	141	220	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	6.7E-20	145	232	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	4.35E-10	145	212	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.9E-16	147	220	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 328 aa Download sequence Send to blast
MSSFVSRESD PTGRQFYCRK EKSLGVLCTK FLRLYNKDGV ESIGLDDAAT KLGVERRRIY 60 DVVNILESVG VVARKQKNQY SWKGFEAIPR ALEGLREEGL KENFSASVPS SSAKVSNENE 120 NEGSSSSKTD CQENSSSATS KSENKREKSL WLLTQNFVKL FLCSGVNMIT LDSAAMSLLG 180 DSLTSTAMRT KVRRLYDIAN VFSSMNLIEK RNRVESATDW NSNQKENVSV LHGCKNLGSD 240 CEENKLNQST KHSSKNFQFG PFSPVAVPTA SNSGNKTVNR IQDLESLAST YCPQYHNQVL 300 SDLFGHYVEA WKSWYVEVAV KEKSQNGS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	7e-33	19	210	4	221	Transcription factor E2F8
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	55	76	RRRIYDVVNILESVGVVARKQK

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15308755}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	29822.m003421

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_025012798.1	0.0	E2F transcription factor-like E2FF
Swissprot	Q8RWL0	1e-106	E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBL	B9RUH4	0.0	B9RUH4_RICCO; E2F, putative
STRING	XP_002517419.1	0.0	(Ricinus communis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3668	33	66

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G01330.1	1e-102	DP-E2F-like protein 3

Link Out ? help Back to Top
Phytozome	29822.m003421

Publications ? help Back to Top
Dohmann EM, et al. The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development, 2008. 135(11): p. 2013-22 [PMID:18434413]