PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 462846299
Organism
Eragrostis tef
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Eragrostideae; Eragrostidinae; Eragrostis
Family E2F/DP
Protein Properties Length: 414aa    MW: 45377.7 Da    PI: 4.6577
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
462846299genomeTefView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.86.9e-2797162171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++ll+++++gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  462846299  97 RYDSSLGLLTKKFINLLKHAPDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 162
                6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.3E-2994164IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.96E-1897160IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-3597162IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.2E-2499162IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146603.74E-49172278No hitNo description
SuperFamilySSF1440741.26E-34175278No hitNo description
PfamPF164217.6E-34177276IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 414 aa     Download sequence    Send to blast
PAAAAAPAAA TSGGVGAESI EEGLVIRTPL KRKAASEEND AAESNECMII SPMLTPVSGK  60
TSKTSKSKAK NNKAGPQTPT SNIGSPLNPS TPAGTCRYDS SLGLLTKKFI NLLKHAPDGI  120
LDLNNAAETL EVQKRRIYDI TNVLEGIGLI EKTLKNRIRW KGLDDSGSEL DNGVSALQAE  180
VENLSLQEQA LDERISDMRE KLRNLTEHEN NQRWLYVTED DIKGLPCFQN ETLIAIKAPH  240
GTTLEVPDPD EAGEYLQRRY RIVLRSTMGP IDVYLVSQFD EKIEDLGSAA TPVKHTNLPR  300
HQPAEDFNTI NAGQSSTSQD VVHNVQHIQK TPQDPSASQD FGGMTRILPS DDTEADYWLL  360
TEGDVSITDM WKTAQVQWDQ MDFLSEEVTT PRAHNQQAVA VGGPQMQIQN MDKP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-2489163274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap462846299
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004952668.10.0transcription factor E2FA
SwissprotQ9FNY01e-123E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A3L6RSU20.0A0A3L6RSU2_PANMI; Transcription factor E2FA-like
STRINGSi017108m0.0(Setaria italica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-118E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]