PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 462949585
Organism
Eragrostis tef
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Chloridoideae; Eragrostideae; Eragrostidinae; Eragrostis
Family E2F/DP
Protein Properties Length: 381aa    MW: 41902.1 Da    PI: 9.031
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
462949585genomeTefView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.31.3e-233499171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rkeksL+ll+++f++l+ + +++ + l+++ak+L    v  +rRRiYDi+NVLe+++++ +k+kn+++w+g
  462949585 34 RKEKSLGLLCSNFVALYDRDNAEPIGLDDAAKSL---GV--ERRRIYDIVNVLESVGILMRKAKNRYTWIG 99
               79********************************...**..****************************98 PP
2E2F_TDP77.99.3e-25158237170
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwk 70 
                rkeksL+lltq+f+kl+ + e ++++l++++k L++e     ++++k+RR+YDi+NVL++lnliek     ++k+++rw 
  462949585 158 RKEKSLGLLTQNFVKLFLTMEVDTISLDQASKLLLAEghedtNMRTKVRRLYDIANVLSSLNLIEKvhqenTKKPAFRWL 237
                79*****************************************************************9999999****95 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.5E-2730100IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.17E-163398IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.9E-283499IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.0E-213599IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.5E-22154237IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-30158238IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-19159237IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.67E-12160236IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 381 aa     Download sequence    Send to blast
MATAASMVAS SSCVAQAAAA AGGATKSRHH SYSRKEKSLG LLCSNFVALY DRDNAEPIGL  60
DDAAKSLGVE RRRIYDIVNV LESVGILMRK AKNRYTWIGF DGVPMAMREL KVCVAPLRDN  120
STMSDDEDDD KLGDPDGDTD SEKLSQTVSN PSDKPDHRKE KSLGLLTQNF VKLFLTMEVD  180
TISLDQASKL LLAEGHEDTN MRTKVRRLYD IANVLSSLNL IEKVHQENTK KPAFRWLTKG  240
GRPKTEAGVT VDVPLSAKTV SNKRTFGTDL TNTNRSNLDS TIQKKAKMAQ SGSDILSSCK  300
LSVQSRLGQG SRSGFVYGPF HPASARKQEP GGANKSGQRE RAEDWESLSA SFRPQYQNQG  360
LGDLFAHYVE AWKSWYSDLA Q
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-36332323232Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap462949585
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_025795108.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-101E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2S3GT590.0A0A2S3GT59_9POAL; Uncharacterized protein
STRINGOMERI02G29820.10.0(Oryza meridionalis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP31853884
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-102DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]