PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 482574
Common NameARALYDRAFT_482574, E2F3
Organism
Arabidopsis lyrata
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 487aa    MW: 52854.9 Da    PI: 4.9691
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
482574genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.24.5e-26167232171
  E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
              r+++sL+llt+kf++l++++++g+++ln++a++L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
   482574 167 RYDSSLGLLTKKFVNLIKQAKDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPFKNRILWKG 232
              6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.0E-28163234IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.63E-16167230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.2E-32167232IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.2E-23169232IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146602.95E-49244348No hitNo description
SuperFamilySSF1440742.25E-32244348No hitNo description
PfamPF164217.4E-33247346IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 487 aa     Download sequence    Send to blast
MSGLVRSSPG SSHPPPPPPH HPPSSPVPVT STPVVPPIRR HLAFASTKPP FHPSDDYHRF  60
NPSSLTNNND RSFVNACGVV DREEDAVVVR SPSRKRKSTM DMVVAPSNNG FTSSGFTSIP  120
SSPCQTPAKG GRVNIKSKAK GNKSTPQTPI STNAGSPVTL TPSGSCRYDS SLGLLTKKFV  180
NLIKQAKDGM LDLNKAAETL EVQKRRIYDI TNVLEGIDLI EKPFKNRILW KGVDASPGDE  240
DADVSVLQAE IENLALEEQA LDNQIRQTEE RLRDLSENEK NQKWLFVTEE DIKSLPGFQN  300
QTLIAVKAPH GTTLEVPDPD EAVDHPQRRY RIILRSTMGP IDVYLVSEFE GKFEDTNGSV  360
AAPPACLPIA SSSGSTGHHD IEALTVDNTG TAIEHQVSHD HPHPQPGDTS DLNYLQEQVG  420
GMLKITPSDV ENDESDYWLL SSAEISMTDI WKTDSGIDWD YGIADVSTPP PGMGEIAPTA  480
VDSTPR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-23162233274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
19297SRKRKS
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Function -- GeneRIF ? help Back to Top
  1. we reveal that the small GTPase Rho-related protein 2 (ROP2) transduces light-auxin signal to activate TOR by direct interaction, which, in turn, promotes transcription factors E2Fa,b for activating cell cycle genes in shoot apexes. Consistently, constitutively activated ROP2 plants stimulate TOR in the shoot apex and cause true leaf development even without light.
    [PMID: 28223530]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap482574
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF2425820.0AF242582.1 Arabidopsis thaliana E2F transcription factor-3 E2F3 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002879589.10.0transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLD7LIM90.0D7LIM9_ARALL; E2F transcription factor-3
STRINGfgenesh2_kg.4__1634__AT2G36010.30.0(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]
  2. Li X, et al.
    Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(10): p. 2765-2770
    [PMID:28223530]