PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

676752346

Organism

Sisymbrium irio

Taxonomic ID

3730

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium

Family

C2H2

Protein Properties

Length: 468aa MW: 54034.9 Da PI: 7.536

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
676752346	genome	VEGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	11.3	0.0011	196	218	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 + C+ C +rk++L+rH+r++ 676752346 196 FFCEFCLNFMKRKEQLQRHMRKC 218 67*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54160	1.1E-23	46	163	IPR016197	Chromo domain-like
Gene3D	G3DSA:2.30.30.270	1.3E-35	51	123	No hit	No description
Pfam	PF11717	4.5E-19	53	111	IPR025995	RNA binding activity-knot of a chromodomain
CDD	cd00024	5.96E-7	66	112	No hit	No description
SMART	SM00298	1.1E-7	67	126	IPR000953	Chromo/chromo shadow domain
Gene3D	G3DSA:2.30.30.270	1.3E-35	157	207	No hit	No description
PROSITE profile	PS51726	71.821	162	463	IPR002717	Histone acetyltransferase domain, MYST-type
SuperFamily	SSF55729	1.85E-105	163	291	IPR016181	Acyl-CoA N-acyltransferase
Gene3D	G3DSA:3.40.630.30	2.7E-69	221	394	IPR016181	Acyl-CoA N-acyltransferase
Pfam	PF01853	3.7E-33	223	294	IPR002717	Histone acetyltransferase domain, MYST-type
CDD	cd04301	0.00515	314	362	No hit	No description
SuperFamily	SSF55729	1.85E-105	322	464	IPR016181	Acyl-CoA N-acyltransferase
Pfam	PF01853	5.5E-43	323	430	IPR002717	Histone acetyltransferase domain, MYST-type

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006281	Biological Process	DNA repair
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010224	Biological Process	response to UV-B
GO:2000028	Biological Process	regulation of photoperiodism, flowering
GO:0005634	Cellular Component	nucleus
GO:0043995	Molecular Function	histone acetyltransferase activity (H4-K5 specific)

Sequence ? help Back to Top
Protein Sequence Length: 468 aa Download sequence Send to blast
MGSSANTETT NLTASPATNG GDANPNHNSA AMIDRKSSEL DASKKRRTGV LPLEVGTRVA 60 CLWRDGKYHP VKVIERRKNH SDGNNEYEYY VHYTEFNRRL DEWIKLDQLD LGSVECALDE 120 KVEDKVTSLK MTRHQKRKID ETHVEGHEEL DAASLREHEE FTKVKNIATI ELGKYEIETW 180 YFSPFPPEYN DCVKLFFCEF CLNFMKRKEQ LQRHMRKCDL KHPPGDEIYR SSTLSMFEVD 240 GKKNKVYAQN LCYLAKLFLD HKTLYYDVDL FLFYILCECD DRGCHMVGYF SKNILVTTGM 300 WHINRQLLAD CIHISLCLVI ISEKHSEEAY NLACILTLPP YQRKGYGKFL IAFSYELSKK 360 EGKVGTPERP LSDLGLVSYR GYWTRILLDI LKKHKGNISI KELSDMTAIK AEDILSTLQS 420 LELIQYRKGQ HVICADPKVL DRHLKAAGRG GLDVDVSKMI WTPYKEQS

Sequence ? help Back to Top

Protein Sequence Length: 468 aa Download sequence Send to blast

MGSSANTETT NLTASPATNG GDANPNHNSA AMIDRKSSEL DASKKRRTGV LPLEVGTRVA  60
CLWRDGKYHP VKVIERRKNH SDGNNEYEYY VHYTEFNRRL DEWIKLDQLD LGSVECALDE  120
KVEDKVTSLK MTRHQKRKID ETHVEGHEEL DAASLREHEE FTKVKNIATI ELGKYEIETW  180
YFSPFPPEYN DCVKLFFCEF CLNFMKRKEQ LQRHMRKCDL KHPPGDEIYR SSTLSMFEVD  240
GKKNKVYAQN LCYLAKLFLD HKTLYYDVDL FLFYILCECD DRGCHMVGYF SKNILVTTGM  300
WHINRQLLAD CIHISLCLVI ISEKHSEEAY NLACILTLPP YQRKGYGKFL IAFSYELSKK  360
EGKVGTPERP LSDLGLVSYR GYWTRILLDI LKKHKGNISI KELSDMTAIK AEDILSTLQS  420
LELIQYRKGQ HVICADPKVL DRHLKAAGRG GLDVDVSKMI WTPYKEQS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4dnc_A	1e-112	158	467	1	282	Histone acetyltransferase KAT8
4dnc_B	1e-112	158	467	1	282	Histone acetyltransferase KAT8
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Functional Description ? help Back to Top
Source	Description
UniProt	Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269\|PubMed:17877703, ECO:0000269\|PubMed:19040736, ECO:0000269\|PubMed:22170978, ECO:0000269\|PubMed:23273925}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	676752346

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269\|PubMed:22170978}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AB493812	0.0	AB493812.1 Arabidopsis thaliana At5g64610 mRNA for hypothetical protein, partial cds, clone: RAAt5g64610.
GenBank	AY099684	0.0	AY099684.1 Arabidopsis thaliana histone acetyltransferase (At5g64610) mRNA, complete cds.
GenBank	BT000277	0.0	BT000277.1 Arabidopsis thaliana histone acetyltransferase (At5g64610) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006394133.1	0.0	histone acetyltransferase of the MYST family 1
Swissprot	Q9FLF7	0.0	MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBL	V4KJM1	0.0	V4KJM1_EUTSA; Histone acetyltransferase
STRING	XP_006394133.1	0.0	(Eutrema salsugineum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM4806	5	6

Publications ? help Back to Top
Latrasse D, et al. The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis. BMC Plant Biol., 2008. 8: p. 121 [PMID:19040736] Campi M,D'Andrea L,Emiliani J,Casati P Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA. Plant Physiol., 2012. 158(2): p. 981-95 [PMID:22170978] Bari A,Orazova S,Ivashchenko A miR156- and miR171-binding sites in the protein-coding sequences of several plant genes. Biomed Res Int, 2013. 2013: p. 307145 [PMID:23936788] Xu Y, et al. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res., 2014. 42(17): p. 10960-74 [PMID:25183522] Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB 3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana. J Mol Model, 2016. 22(11): p. 256 [PMID:27709438] Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis. Front Plant Sci, 2017. 8: p. 1179 [PMID:28740501]