PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AA40G00587
Organism
Aethionema arabicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema
Family E2F/DP
Protein Properties Length: 354aa    MW: 40234.3 Da    PI: 9.1932
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AA40G00587genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.87.8e-231176171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rkeksL++l ++fl+l+++s+ + + l+++a +L    v  +rRRiYD++N+Le+++l++++ kn+++wkg
  AA40G00587 11 RKEKSLGVLVSNFLRLYNRSDVDLIGLDDAAGKL---GV--ERRRIYDVVNILESIGLVARRGKNQYSWKG 76
                79********************************...**..****************************98 PP
2E2F_TDP80.21.9e-25136216171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 +keksL+ll+q+f+kl+ +s+++ +tl+ ++k+L+++     ++++k+RR+YDi+NV++++nliek     ++k+++rw g
  AA40G00587 136 KKEKSLWLLAQNFVKLFLCSDNDLITLDGATKALLNDsqdpmNMRTKVRRLYDIANVFSSMNLIEKthipeTRKPAYRWLG 216
                 69*****************************************************************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.1E-24777IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.43E-161074IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-261176IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.2E-191276IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.8E-22131218IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.6E-30136216IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.1E-19137216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.32E-12138217IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 354 aa     Download sequence    Send to blast
MESLGRQSYN RKEKSLGVLV SNFLRLYNRS DVDLIGLDDA AGKLGVERRR IYDVVNILES  60
IGLVARRGKN QYSWKGFGEV PRALSELKEE GMREKYGIIP SVSKSEMVLY DDAREEPLKL  120
TPEDQENSPS SKNDNKKEKS LWLLAQNFVK LFLCSDNDLI TLDGATKALL NDSQDPMNMR  180
TKVRRLYDIA NVFSSMNLIE KTHIPETRKP AYRWLGPKAM SENIPIAAPA SSCCYNESKK  240
RVFGTEITNL NSKRNKTDPS TDQNQKNKSS FNAQQQQQQC SSKPASKKSF VFGPFTPTGS  300
STKYDTENNS NQTLEDLETL SSSHHLRYCN HDLIGLLGHY TEAWRSWHAE FGRK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-33102083228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAA40G00587
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006400017.10.0E2F transcription factor-like E2FD
SwissprotQ8RWL01e-157E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLV4KU260.0V4KU26_EUTSA; Uncharacterized protein
STRINGXP_006400017.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-153DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]