PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AA44G00405

Organism

Aethionema arabicum

Taxonomic ID

228871

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema

Family

MYB

Protein Properties

Length: 933aa MW: 104228 Da PI: 5.1221

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AA44G00405	genome	VEGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	56.1	8.6e-18	36	82	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 rg WT+eEde l +av+ + g++Wk+Ia+++ Rt+ qc +rwqk+l AA44G00405 36 RGQWTAEEDEVLRKAVHSFNGKNWKKIAEYFK-DRTDVQCLHRWQKVL 82 89***************************9.**********986 PP
2	Myb_DNA-binding	59.6	6.7e-19	88	134	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g+WT+eEd++++++v + G++ W+tIar+++ gR +kqc++rw+++l AA44G00405 88 KGPWTKEEDDKIIELVGEIGPKKWSTIARYLP-GRIGKQCRERWHNHL 134 79****************************.***********97 PP
3	Myb_DNA-binding	43.3	8.2e-14	140	182	1	45
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwq 45 + +WT+eE++ l++a++++G++ W+ + ++ gR+++ +k++w+ AA44G00405 140 KEAWTQEEELVLIRAHQLYGNR-WAELTKFLP-GRSDNGIKNHWH 182 579*****************.*****.*********8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	17.716	31	82	IPR017930	Myb domain
SuperFamily	SSF46689	1.0E-15	33	89	IPR009057	Homeodomain-like
SMART	SM00717	1.1E-14	35	84	IPR001005	SANT/Myb domain
Pfam	PF00249	1.5E-15	36	82	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	2.5E-22	37	90	IPR009057	Homeodomain-like
CDD	cd00167	3.29E-13	39	82	No hit	No description
PROSITE profile	PS51294	31.661	83	138	IPR017930	Myb domain
SuperFamily	SSF46689	7.49E-30	85	181	IPR009057	Homeodomain-like
SMART	SM00717	3.5E-17	87	136	IPR001005	SANT/Myb domain
Pfam	PF00249	2.7E-17	88	134	IPR001005	SANT/Myb domain
CDD	cd00167	1.45E-14	90	134	No hit	No description
Gene3D	G3DSA:1.10.10.60	3.0E-26	91	137	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	4.2E-20	138	189	IPR009057	Homeodomain-like
SMART	SM00717	1.4E-12	139	187	IPR001005	SANT/Myb domain
PROSITE profile	PS51294	18.314	139	189	IPR017930	Myb domain
Pfam	PF00249	4.8E-12	140	182	IPR001005	SANT/Myb domain
CDD	cd00167	1.17E-9	142	182	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0032875	Biological Process	regulation of DNA endoreduplication
GO:0003677	Molecular Function	DNA binding
GO:0003713	Molecular Function	transcription coactivator activity

Sequence ? help Back to Top
Protein Sequence Length: 933 aa Download sequence Send to blast
MEGDCTPSLT PPEGLIDANQ RSRHGRTTGP ARRSTRGQWT AEEDEVLRKA VHSFNGKNWK 60 KIAEYFKDRT DVQCLHRWQK VLNPELVKGP WTKEEDDKII ELVGEIGPKK WSTIARYLPG 120 RIGKQCRERW HNHLNPAINK EAWTQEEELV LIRAHQLYGN RWAELTKFLP GRSDNGIKNH 180 WHSSVKKKLE SYVSSGLLDQ CQTLPLTPYE RSSMLPSAVM QRTIDENGCL SVNSENCQNS 240 SMVGSSLSAS DYPNQVINIG HHFQNSQENE QAASVTYQTD QYFYPDLEDI SISISDISYD 300 MEDCSQFTDH NVATSSSQDY QFDIQELSDI SHEMTQNTSD VPIPYTKDSK KESNNSANEM 360 IPDTECCRVL FQDQESEGIS ASKSLTQEPN EVDQADYQDP TLCASASDNQ RSESTKSPLQ 420 SCSSRSIATA ASGKETLRPA PLIISPDKHA NETSSRLIFH PSAATPKRRA NANGSFICTG 480 DPSSSTCGDQ DNNNSSQQDQ SYRVSDSKKL VAVNDFASLA EVKEHSRPDH QPNMTNQQHH 540 EDMDASSLCF PSLDLPVFSS DLLQSKNDLL QDYSPLGIRK LLMSTVTCMS PLRLWESPTG 600 KKTLVGKQSI LKKRTRDLLT PISEKRSDKK LEIDIAASLA NDFSRLEVMF DESCDRESIS 660 GEKTSVNLGE NHHQTFNEDD EESWRMKPSR KSLEKAEQTS MEEHAKGNDD SEPDVVHTES 720 LSGVLAEHNT NKLELTTPSK SVTKSVKGQG STPRNHLQRT LIATSNKEGL CLVLNSPSRT 780 RNTEEINHEN FSIFCGTPFR RGLESPSAWK SPFYMNSLLP SPRFNTDITI EDIGYIFSPG 840 ERSYNGGGPM TDNNNNEAAQ AAADALADIM EFSGSIILRE DKMKQKELNK ENDEPTMTER 900 RVLDFDCLSP TKPTNSSETS IAAVSSSSSS LKG

Sequence ? help Back to Top

Protein Sequence Length: 933 aa Download sequence Send to blast

MEGDCTPSLT PPEGLIDANQ RSRHGRTTGP ARRSTRGQWT AEEDEVLRKA VHSFNGKNWK  60
KIAEYFKDRT DVQCLHRWQK VLNPELVKGP WTKEEDDKII ELVGEIGPKK WSTIARYLPG  120
RIGKQCRERW HNHLNPAINK EAWTQEEELV LIRAHQLYGN RWAELTKFLP GRSDNGIKNH  180
WHSSVKKKLE SYVSSGLLDQ CQTLPLTPYE RSSMLPSAVM QRTIDENGCL SVNSENCQNS  240
SMVGSSLSAS DYPNQVINIG HHFQNSQENE QAASVTYQTD QYFYPDLEDI SISISDISYD  300
MEDCSQFTDH NVATSSSQDY QFDIQELSDI SHEMTQNTSD VPIPYTKDSK KESNNSANEM  360
IPDTECCRVL FQDQESEGIS ASKSLTQEPN EVDQADYQDP TLCASASDNQ RSESTKSPLQ  420
SCSSRSIATA ASGKETLRPA PLIISPDKHA NETSSRLIFH PSAATPKRRA NANGSFICTG  480
DPSSSTCGDQ DNNNSSQQDQ SYRVSDSKKL VAVNDFASLA EVKEHSRPDH QPNMTNQQHH  540
EDMDASSLCF PSLDLPVFSS DLLQSKNDLL QDYSPLGIRK LLMSTVTCMS PLRLWESPTG  600
KKTLVGKQSI LKKRTRDLLT PISEKRSDKK LEIDIAASLA NDFSRLEVMF DESCDRESIS  660
GEKTSVNLGE NHHQTFNEDD EESWRMKPSR KSLEKAEQTS MEEHAKGNDD SEPDVVHTES  720
LSGVLAEHNT NKLELTTPSK SVTKSVKGQG STPRNHLQRT LIATSNKEGL CLVLNSPSRT  780
RNTEEINHEN FSIFCGTPFR RGLESPSAWK SPFYMNSLLP SPRFNTDITI EDIGYIFSPG  840
ERSYNGGGPM TDNNNNEAAQ AAADALADIM EFSGSIILRE DKMKQKELNK ENDEPTMTER  900
RVLDFDCLSP TKPTNSSETS IAAVSSSSSS LKG

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h88_C	4e-66	36	189	6	159	MYB PROTO-ONCOGENE PROTEIN
1h89_C	4e-66	36	189	6	159	MYB PROTO-ONCOGENE PROTEIN
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (PubMed:21862669). Involved in the regulation of cytokinesis, probably via the activation of several G2/M phase-specific genes transcription (e.g. KNOLLE) (PubMed:17287251, PubMed:21862669, PubMed:25806785). Required for the maintenance of diploidy (PubMed:21862669). {ECO:0000269\|PubMed:17287251, ECO:0000269\|PubMed:21862669, ECO:0000269\|PubMed:25806785}.; FUNCTION: Involved in transcription regulation during induced endoreduplication at the powdery mildew (e.g. G.orontii) infection site, thus promoting G.orontii growth and reproduction. {ECO:0000269\|PubMed:20018666}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00505	DAP	Transfer from AT5G11510	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AA44G00405

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Slightly induced by salicylic acid (SA) (PubMed:16463103). Expressed in a cell cycle-dependent manner, with highest levels 2 hours before the peak of mitotic index in cells synchronized by aphidicolin. Activated by CYCB1 (PubMed:17287251). Accumulates at powdery mildew (e.g. G.orontii) infected cells. {ECO:0000269\|PubMed:16463103, ECO:0000269\|PubMed:17287251}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF371975	0.0	AF371975.2 Arabidopsis thaliana putative c-myb-like transcription factor MYB3R-4 (MYB3R4) mRNA, complete cds.
GenBank	AY519650	0.0	AY519650.1 Arabidopsis thaliana MYB transcription factor (At5g11510) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006399657.1	0.0	transcription factor MYB3R-4
Swissprot	Q94FL9	0.0	MB3R4_ARATH; Transcription factor MYB3R-4
TrEMBL	A0A087G6B1	0.0	A0A087G6B1_ARAAL; Myb-related protein 3r-1-like
STRING	A0A087G6B1	0.0	(Arabis alpina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM13213	18	28

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G11510.1	0.0	myb domain protein 3r-4

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Saito T, et al. Genetic interaction between G2/M phase-specific transcription factor MYB3R4 and MAPKKK ANP3 for execution of cytokinesis in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(3): p. e990817 [PMID:25806785] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Chen P, et al. Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]