PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AA50G00006
Organism
Aethionema arabicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema
Family bHLH
Protein Properties Length: 364aa    MW: 41493.2 Da    PI: 4.8702
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AA50G00006genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.32.4e-12190241155
                 CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
         HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                 +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  AA50G00006 190 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 241
                 79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.2E-13188244IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.64E-12188245No hitNo description
PROSITE profilePS5088815.428189240IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.83E-16189254IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.1E-9190241IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9195246IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 364 aa     Download sequence    Send to blast
MDKDYSGSSQ DGPWLAPNFL GESSGGNEEN NSGMIDYMFI RNLEQHKQSQ TQNQQQQQLS  60
PSFDKMSFAD VMQFADFGPK LALNQTNNIQ EDQETGIDPV YFLKFPVLND KTENQQQQQH  120
LMTSHQSRDT VFLEDEEEEE ETRVSDTNEN NSVQLRFIGE EDRNVTRTKE VKSKRKRART  180
SKTSEEVESQ RMTHIAVERN RRKQMNEHLR VLRSLMPGSY VQRGDQASII GGAIEFVREL  240
EQLLQCLESQ KRRRIFGDSG HRQIGDMTTT ASSPPLTGVS NQSQPLIIPD LEAEGLREET  300
AESKSSLADV EVKLIGFDAM IKILSRRRSG QLIKTIAALE DLQLSILHTN ITTMEQTVLY  360
SFNV
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1190201RMTHIAVERNRR
2250254KRRRI
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAA50G00006
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002883481.21e-178transcription factor FAMA
RefseqXP_009135875.11e-179PREDICTED: transcription factor FAMA isoform X1
RefseqXP_013685446.11e-179transcription factor FAMA isoform X1
SwissprotQ56YJ81e-170FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A398A5T51e-177A0A398A5T5_BRACM; Uncharacterized protein
TrEMBLD7L4811e-177D7L481_ARALL; Uncharacterized protein
TrEMBLM4CCJ91e-177M4CCJ9_BRARP; Uncharacterized protein
STRINGBra001929.1-P1e-178(Brassica rapa)
STRINGscaffold_302925.11e-178(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM55482649
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-134bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]