PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AA53G01357
Organism
Aethionema arabicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema
Family bHLH
Protein Properties Length: 606aa    MW: 68008.4 Da    PI: 4.9125
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AA53G01357genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH43.94.3e-14423470355
                 HHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
         HLH   3 rahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                 ++h   Er+RR+++N++f +Lr+++P+      +K +K++iL  ++eY+++Lq
  AA53G01357 423 ANHALSERKRREKLNERFITLRSIIPSI-----TKIDKVSILDDTIEYLQELQ 470
                 58999**********************7.....6******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142155.5E-5313203IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.06420469IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.44E-18422483IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.3E-11423470IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.99E-15424474No hitNo description
Gene3DG3DSA:4.10.280.109.0E-18424487IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003535.8E-17426475IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009957Biological Processepidermal cell fate specification
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 606 aa     Download sequence    Send to blast
MGTEENRRVP ENLKKQLAVS IRSIQWSYGI FWSISPTQPG VLEWGEGYYN GDIKTRKTIQ  60
AGEVKVDKLG LQRSEQLREL YDSLSLAESS ASGSNSQVTR RTSATALSPE DLTDTEWYYL  120
VCMSFLFNNG EGIPGRVLAN EEPIWLCNAQ TADSKVFTRS LLAKSASVQT VVCFPFLGGV  180
LEIGTTEHIT EDLNLIQCVK TSFLEASSFA TLSTRSDYHD IFDPLSENGY IPVFGTEAFP  240
TVSASEFEPE TEQEAEDHDS FMAEGINGGG SSQVQSWQFV GEEFSNCVHQ SLNSSDCVSQ  300
TFAKTVGGRV ASDPRKSKVQ RLSQIQERNN QIKLDDDEHY QTVISTIFKT THQLILGPQF  360
QNCDKRSSFT RWKRSRTTFH GKNELSSQRI LKKILLEIPV LHQKELLIDT PEDSGVKIGD  420
ETANHALSER KRREKLNERF ITLRSIIPSI TKIDKVSILD DTIEYLQELQ RRVQELESCR  480
ESTDNETTLK RKKPEDEGER MSANCMKNMS VEAEPVHDTG YAGLTDNLRI GLFGDEVVIE  540
LRCAWREGIL LEIMDVISDL NLDSHSVQSS TGDGLLCLTV NCKHKGSKMA TPGLIQEAIQ  600
RVAWIC
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A6e-15112037192Transcription factor MYC3
4rqw_B6e-15112037192Transcription factor MYC3
4rs9_A6e-15112037192Transcription factor MYC3
4yz6_A6e-15112037192Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1428433ERKRRE
2429434RKRREK
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2. {ECO:0000269|PubMed:12917293, ECO:0000269|PubMed:12956536, ECO:0000269|PubMed:14627722, ECO:0000269|PubMed:15361138, ECO:0000269|PubMed:15590742}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAA53G01357
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By UV treatment. Negatively regulated by MYB66/WER, GL3 and BHLH2 in the developing non-hair cells, and positively regulated by CPC and TRY in the developing hair cells. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15590742}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006391734.10.0transcription factor EGL1
SwissprotQ9CAD00.0EGL1_ARATH; Transcription factor EGL1
TrEMBLE4MXH00.0E4MXH0_EUTHA; mRNA, clone: RTFL01-32-J06
TrEMBLV4JUJ60.0V4JUJ6_EUTSA; Uncharacterized protein
STRINGXP_006391734.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM25922867
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G63650.30.0bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Liu Z,Shi MZ,Xie DY
    Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins.
    Planta, 2014. 239(4): p. 765-81
    [PMID:24370633]
  3. Nayidu NK, et al.
    Comparison of five major trichome regulatory genes in Brassica villosa with orthologues within the Brassicaceae.
    PLoS ONE, 2014. 9(4): p. e95877
    [PMID:24755905]
  4. Cheng Y, et al.
    Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases.
    Elife, 2018.
    [PMID:24771765]
  5. Ranocha P,Francoz E,Burlat V,Dunand C
    Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.
    Plant Signal Behav, 2014. 9(11): p. e977734
    [PMID:25531128]
  6. Nemie-Feyissa D,Heidari B,Blaise M,Lillo C
    Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis.
    Phytochemistry, 2015. 111: p. 21-6
    [PMID:25659750]
  7. Kwak SH,Song SK,Lee MM,Schiefelbein J
    TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana.
    Plant Signal Behav, 2015. 10(12): p. e1103407
    [PMID:26451798]
  8. Dai X, et al.
    A single amino acid substitution in the R3 domain of GLABRA1 leads to inhibition of trichome formation in Arabidopsis without affecting its interaction with GLABRA3.
    Plant Cell Environ., 2016. 39(4): p. 897-907
    [PMID:26667588]
  9. Friede A, et al.
    The Second Intron Is Essential for the Transcriptional Control of the Arabidopsis thaliana GLABRA3 Gene in Leaves.
    Front Plant Sci, 2017. 8: p. 1382
    [PMID:28848584]
  10. Feng K, et al.
    An R2R3-MYB transcription factor, OjMYB1, functions in anthocyanin biosynthesis in Oenanthe javanica.
    Planta, 2018. 247(2): p. 301-315
    [PMID:28965159]
  11. Wen J, et al.
    The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.
    Plant Signal Behav, 2018. 13(1): p. e1422460
    [PMID:29293407]