PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AA5G00029
Organism
Aethionema arabicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Aethionemeae; Aethionema
Family E2F/DP
Protein Properties Length: 336aa    MW: 37510.1 Da    PI: 8.797
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AA5G00029genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.41.2e-232287171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rk+ksL+ll+++fl+l+++   + + l+++a++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  AA5G00029 22 RKQKSLGLLCTNFLALYNRDGIELIGLDDAAQKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 87
               79*****************999************...**..****************************98 PP
2E2F_TDP72.83.8e-23157227166
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliekkekne 66 
                r+eksL+lltq+f+kl+ +se+++++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek   n+
  AA5G00029 157 RREKSLGLLTQNFIKLFVCSEAKVISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKILENQ 227
                689**************************************999**********************55554 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.1E-261888IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.09E-162185IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.8E-282287IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-202387IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.7E-19155226IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-23157238IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.35E-12159225IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.9E-18159226IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 336 aa     Download sequence    Send to blast
MTLSSSSSLP ESSSSRHHSY SRKQKSLGLL CTNFLALYNR DGIELIGLDD AAQKLGVERR  60
RIYDIVNVLE SVGVLTRRAK NQYTWKGFAA IPGALNVLKD EGIKDTFHRF YVNENVKGSD  120
DEDDEEDCSQ PYSSSQTDSS KPGCLLTSSA SSKIDHRREK SLGLLTQNFI KLFVCSEAKV  180
ISLDEAAKLL LGDAHNTSIM RTKVRRLYDI ANVLSSMNLI EKILENQLSA DKRLKMTKQA  240
ITVSSYTKTN HPQEPKQGSR GHEFGPFAPS SGTSAIATSP ESSRTVFDLE NLANSHSPSY  300
QNQVLKDLFS HYMDAWKSWY SEVTKKNSLQ NSSKQH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-39212233222Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAA5G00029
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020880368.11e-170E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-159E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLD7LRJ41e-166D7LRJ4_ARALL; Uncharacterized protein
STRINGfgenesh2_kg.5__1169__AT3G48160.21e-167(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-144DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]