PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AHYPO_001518-RA

Organism

Amaranthus hypochondriacus

Taxonomic ID

28502

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Amaranthaceae; Amaranthus

Family

E2F/DP

Protein Properties

Length: 260aa MW: 29390.3 Da PI: 8.7708

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AHYPO_001518-RA	genome	BYU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	72.3	5.3e-23	21	86	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rk+ksL+ll+++f+ l+++ + + l+++a++L v +rRRiYDi+N+Le+++++++k+kn+++wkg AHYPO_001518-RA 21 RKQKSLGLLCSNFIGLYNRDGVESIGLDDAANKL---GV--ERRRIYDIVNILESVGVLARKAKNQYTWKG 86 79***************999********.....****************************98 PP
2	E2F_TDP	30.6	5.4e-10	133	203	1	52
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse...................dvknkrRRiY..DilNV 52 r+eksL+lltq+f+kl+ +s+ + ++lne+ak+L++ +++ R++ Di+N+ AHYPO_001518-RA 133 RREKSLGLLTQNFVKLFICSNVDLISLNEAAKTLLAFrwlglrewseatipcvpmpT--ESKKRVFgsDITNI 203 689*******************************88788888888888888887633..36777776677775 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.1E-25	17	87	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.32E-15	20	84	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	5.3E-27	21	86	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.5E-20	22	86	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	4.1E-8	130	203	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	0.0023	133	173	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 260 aa Download sequence Send to blast
MATSPPLIPD DSGSRDHAYS RKQKSLGLLC SNFIGLYNRD GVESIGLDDA ANKLGVERRR 60 IYDIVNILES VGVLARKAKN QYTWKGFKGI PKALAALKEE SLKENSSSSR SSKMKLQVFE 120 DDEDAHSNPD NNRREKSLGL LTQNFVKLFI CSNVDLISLN EAAKTLLAFR WLGLREWSEA 180 TIPCVPMPTE SKKRVFGSDI TNINFERNRV EFLGQKAKQL KQQVKSENAE TLRDIFDHYT 240 EAWRTWYSEV NGQLLEQVS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	2e-25	20	168	3	187	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010678680.1	1e-116	PREDICTED: E2F transcription factor-like E2FE isoform X2
Swissprot	Q8LSZ4	3e-62	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A0K9R2D5	1e-108	A0A0K9R2D5_SPIOL; Uncharacterized protein
STRING	XP_010678681.1	1e-116	(Beta vulgaris)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.1	2e-59	DP-E2F-like 1

Link Out ? help Back to Top
Phytozome	AHYPO_001518-RA

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]