PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G18550.1
Common NameATHB21, ATHB-21, F24H14.10, HB-2, HB21
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family HD-ZIP
Protein Properties Length: 220aa    MW: 25700.7 Da    PI: 5.1011
Description homeobox protein 21
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G18550.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox62.18.2e-2062115457
                  -SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHHC CS
     Homeobox   4 RttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakekk 57 
                  ++++++eq++ Le  Fe ++++  e++ +LA++lgL+ rqV vWFqNrRa++k+
  AT2G18550.1  62 KRKLSDEQVRMLEISFEDDHKLESERKDRLASELGLDPRQVAVWFQNRRARWKN 115
                  45899***********************************************95 PP
2HD-ZIP_I/II122.42.2e-3961152293
  HD-ZIP_I/II   2 kkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLreelke 93 
                  +kr+ls+eqv++LE sFe ++kLe+erK +la+eLgl+prqvavWFqnrRAR+k+k++E +y++Lk+ay++ + e++rL++ev +L+e+l e
  AT2G18550.1  61 RKRKLSDEQVRMLEISFEDDHKLESERKDRLASELGLDPRQVAVWFQNRRARWKNKRVEDEYTKLKNAYETTVVEKCRLDSEVIHLKEQLYE 152
                  8***************************************************************************************9976 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007117.02256116IPR001356Homeobox domain
SuperFamilySSF466894.28E-1859123IPR009057Homeodomain-like
SMARTSM003893.0E-2059120IPR001356Homeobox domain
CDDcd000865.56E-1761117No hitNo description
PfamPF000464.9E-1762115IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.601.2E-2063122IPR009057Homeodomain-like
PRINTSPR000311.4E-58796IPR000047Helix-turn-helix motif
PROSITE patternPS00027091114IPR017970Homeobox, conserved site
PRINTSPR000311.4E-596112IPR000047Helix-turn-helix motif
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0009001anatomyfruit
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0025281anatomypollen
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 220 aa     Download sequence    Send to blast
MNNQNVDDHN LLLISQLYPN VYTPLVPQQG GEAKPTRRRK RKSKSVVVAE EGENEGNGWF  60
RKRKLSDEQV RMLEISFEDD HKLESERKDR LASELGLDPR QVAVWFQNRR ARWKNKRVED  120
EYTKLKNAYE TTVVEKCRLD SEVIHLKEQL YEAEREIQRL AKRVEGTLSN SPISSSVTIE  180
ANHTTPFFGD YDIGFDGEAD ENLLYSPDYI DGLDWMSQFM
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.528100.0flower
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible265983_at0.0
Expression AtlasAT2G18550-
AtGenExpressAT2G18550-
ATTED-IIAT2G18550-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16055682}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a homeodomain leucine zipper class I (HD-Zip I) protein.
UniProtProbable transcription factor. {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. Data show that the HD-Zip protein Athb-21 and B-3 AP2/ERF transcription factor ESE1 are interact with the abscisic acid responsive element binding factor AREB2/ABF4, which binds to a G-box absolutely required for expression of the COX5b-1 gene.
    [PMID: 22669746]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT2G18550.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By abscisic acid (ABA) and by salt stress. {ECO:0000269|PubMed:16055682}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDBrassinosteroid
Interaction ? help Back to Top
Source Intact With
BioGRIDAT2G36610, AT3G19290, AT5G65410, AT1G69600
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G18550
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0313620.0BT031362.1 Arabidopsis thaliana unknown protein (At2g18550) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_179445.11e-164homeobox protein 21
SwissprotQ9ZU701e-165ATB21_ARATH; Homeobox-leucine zipper protein ATHB-21
TrEMBLC0SV501e-162C0SV50_ARATH; Uncharacterized protein At2g18550 (Fragment)
STRINGAT2G18550.11e-163(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM22082677
Representative plantOGRP37761025
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Son O, et al.
    Induction of a homeodomain-leucine zipper gene by auxin is inhibited by cytokinin in Arabidopsis roots.
    Biochem. Biophys. Res. Commun., 2005. 326(1): p. 203-9
    [PMID:15567172]
  3. Henriksson E, et al.
    Homeodomain leucine zipper class I genes in Arabidopsis. Expression patterns and phylogenetic relationships.
    Plant Physiol., 2005. 139(1): p. 509-18
    [PMID:16055682]
  4. Tan QK,Irish VF
    The Arabidopsis zinc finger-homeodomain genes encode proteins with unique biochemical properties that are coordinately expressed during floral development.
    Plant Physiol., 2006. 140(3): p. 1095-108
    [PMID:16428600]
  5. Comelli RN,Welchen E,Kim HJ,Hong JC,Gonzalez DH
    Delta subclass HD-Zip proteins and a B-3 AP2/ERF transcription factor interact with promoter elements required for expression of the Arabidopsis cytochrome c oxidase 5b-1 gene.
    Plant Mol. Biol., 2012. 80(2): p. 157-67
    [PMID:22669746]
  6. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
    [PMID:23449474]
  7. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  8. González-Grandío E, et al.
    Abscisic acid signaling is controlled by a BRANCHED1/HD-ZIP I cascade in Arabidopsis axillary buds.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(2): p. E245-E254
    [PMID:28028241]