PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT3G01600.1

Common Name

anac044, F4P13.14, NAC044

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

NAC

Protein Properties

Length: 370aa MW: 40827.2 Da PI: 5.4979

Description

NAC domain containing protein 44

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT3G01600.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	99.6	4.5e-31	55	196	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk......lelee.....vikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknra.......tks 80 lp+G++F+Ptde+++ e+L++k+ + e v ++v+i++++P++Lp ++++ +++fF+k+ ++y tg+rk+r+ + AT3G01600.1 55 LPKGVKFEPTDEDII-EFLEAKCGIGGsephvlI---EefirpVTEDVGINYTHPQNLP-GANKDGVSVFFFHKTVQAYGTGQRKRRKitptlvnDEP 147 799**********.9*876664566552...13445467889*******.445566799**************74555554337 PP NAM 81 gyWkatgkdkevlskkgelvglkktLvfykg..rapkgektdWvmheyrl 128 +W++tg++k+v+ +g + g+kk++v+yk + k+ek++Wv+h+y+l AT3G01600.1 148 VRWHKTGRTKPVML-SGVQRGCKKIMVLYKSarKGTKPEKSNWVLHQYHL 196 88********.999*******5432566777*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	5.49E-36	40	214	IPR003441	NAC domain
PROSITE profile	PS51005	29.409	55	214	IPR003441	NAC domain
Pfam	PF02365	7.1E-13	56	196	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007275	Biological Process	multicellular organism development
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 370 aa Download sequence Send to blast
MARAWIVDGR GIAAKVKNAS LSSALQIQDC GAHIKCPNCT YRIDNSNVLI PWPGLPKGVK 60 FEPTDEDIIE FLEAKCGIGG SEPHVLIEEF IRPVTEDVGI NYTHPQNLPG ANKDGVSVFF 120 FHKTVQAYGT GQRKRRKITP TLVNDEPVRW HKTGRTKPVM LSGVQRGCKK IMVLYKSARK 180 GTKPEKSNWV LHQYHLGTEG KEIGDYVVSK ITYQQQKLGE NPDEGESSSG VRGGPTTPKT 240 NTPTPPSLVD GVAGDEEAFD DLKMFDPFFE ELDSIPEAAL GKMWSKKARM DEEFVVNLSE 300 DNLICDESME ASSLWENQVL PNPSLGTVGD FDGFSISDLE NADLGTPPDF LTVRSCLKKT 360 LFTFGKFNGT

Sequence ? help Back to Top

Protein Sequence Length: 370 aa Download sequence Send to blast

MARAWIVDGR GIAAKVKNAS LSSALQIQDC GAHIKCPNCT YRIDNSNVLI PWPGLPKGVK  60
FEPTDEDIIE FLEAKCGIGG SEPHVLIEEF IRPVTEDVGI NYTHPQNLPG ANKDGVSVFF  120
FHKTVQAYGT GQRKRRKITP TLVNDEPVRW HKTGRTKPVM LSGVQRGCKK IMVLYKSARK  180
GTKPEKSNWV LHQYHLGTEG KEIGDYVVSK ITYQQQKLGE NPDEGESSSG VRGGPTTPKT  240
NTPTPPSLVD GVAGDEEAFD DLKMFDPFFE ELDSIPEAAL GKMWSKKARM DEEFVVNLSE  300
DNLICDESME ASSLWENQVL PNPSLGTVGD FDGFSISDLE NADLGTPPDF LTVRSCLKKT  360
LFTFGKFNGT

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.50146	0.0	seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	186509666	0.0
Expression Atlas	AT3G01600	-
AtGenExpress	AT3G01600	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in shoot and root apical meristems, in lateral root primordia, in the vasculature of young leaves and in the root stele. {ECO:0000269\|PubMed:23907539}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT3G01600.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT3G01600

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	ATAC009325	0.0	AC009325.8 Arabidopsis thaliana chromosome III BAC F4P13 genomic sequence, complete sequence.
GenBank	CP002686	0.0	CP002686.1 Arabidopsis thaliana chromosome 3, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001319443.1	0.0	NAC domain containing protein 44
Swissprot	Q6NQK2	5e-73	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	Q9SS95	0.0	Q9SS95_ARATH; F4P13.14 protein
STRING	AT3G01600.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM5045	26	51
Representative plant	OGRP525	15	85

Link Out ? help Back to Top
Phytozome	AT3G01600.1
Entrez Gene	819872
iHOP	AT3G01600
wikigenes	AT3G01600

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Ooka H, et al. Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana. DNA Res., 2003. 10(6): p. 239-47 [PMID:15029955] Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]