PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G08330.1
Common NameAtTCP11, CHE, F8L15.60, TCP11, TCP21
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family TCP
Protein Properties Length: 239aa    MW: 24751.6 Da    PI: 10.2008
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G08330.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1TCP124.41.3e-38251922119
          TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgtssssaseceaesssssas...nsssg........ 88 
                  a+kk +++++h+kv+gR+RR+R+++ caar+F+L++eLG+++d++tieWLl+qa+p+i+++tgt++++as++ ++s s s+        +        
  AT5G08330.1  25 AVKKPPSKDRHSKVDGRGRRIRMPIICAARVFQLTRELGHKSDGQTIEWLLRQAEPSIIAATGTGTTPASFS-TASLSTSSPftlG---Krvvraeeg 118
                  79**************************************************************99999777.2222222222220...133444444 PP

          TCP  89 ........................................................kaaksaakskksqksaasalnlakesrakar 119
                                                                          +             ++ ++l + ++++++a+
  AT5G08330.1 119 esgggggggltvghtmgtslmggggsggfwavparpdfgqvwsfatgappemvfaqQ-------------QQPATLFVRHQQQQQAS 192
                  455667777777777777777777777888888888888777654444433333322.............22223333333333333 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5136928.2093185IPR017887Transcription factor TCP subgroup
PfamPF036341.5E-3231149IPR005333Transcription factor, TCP
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0042752Biological Processregulation of circadian rhythm
GO:0043433Biological Processnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0009052anatomyflower pedicel
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 239 aa     Download sequence    Send to blast
MADNDGAVSN GIIVEQTSNK GPLNAVKKPP SKDRHSKVDG RGRRIRMPII CAARVFQLTR  60
ELGHKSDGQT IEWLLRQAEP SIIAATGTGT TPASFSTASL STSSPFTLGK RVVRAEEGES  120
GGGGGGGLTV GHTMGTSLMG GGGSGGFWAV PARPDFGQVW SFATGAPPEM VFAQQQQPAT  180
LFVRHQQQQQ ASAAAAAAMG EASAARVGNY LPGHHLNLLA SLSGGANGSG RREDDHEPR
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.229110.0floral meristem| flower| root
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306823380.0
Genevisible246011_at0.0
Expression AtlasAT5G08330-
AtGenExpressAT5G08330-
ATTED-IIAT5G08330-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in leaves, roots, and stems. {ECO:0000269|PubMed:19286557}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in the regulation of the circadian clock. Acts as a repressor of CCA1 by binding to its promoter. No binding to the LHY promoter. {ECO:0000269|PubMed:19286557}.
Function -- GeneRIF ? help Back to Top
  1. identification of CHE (At5g08330), a TCP transcription factor that binds specifically to the CCA1 promoter; expression of CHE is regulated by CCA1, thus adding a CCA1/CHE feedback loop to the Arabidopsis circadian network
    [PMID: 19286557]
  2. Expression of a repressor form of TCP11 in plants demonstrates that TCP11 is a developmental regulator that influences growth of leaves, stems and petioles, and pollen development. Distinct DNA-binding of TCP11 is due to T15 residue in TCP domain. [TCP11]
    [PMID: 21241251]
  3. ZTL interacts directly with CHE and can mediate CHE ubiquitylation.CHE protein is degraded in the dark.
    [PMID: 29794020]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00499DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G08330.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G23280, AT5G51910, AT5G60120, AT5G60970, AT1G19000, AT1G24625, AT1G30210, AT1G35560, AT1G53230, AT1G58100, AT1G69690
IntActSearch Q9FTA2
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: No effect on the period length or phase of the circadian clock. {ECO:0000269|PubMed:19286557}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G08330
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4120740.0AF412074.1 Arabidopsis thaliana AT5g08330/F8L15_60 mRNA, complete cds.
GenBankAL3921740.0AL392174.1 Arabidopsis thaliana DNA chromosome 5, BAC clone F8L15 (ESSA project).
GenBankAY0726200.0AY072620.1 Arabidopsis thaliana AT5g08330/F8L15_60 mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_196450.11e-174TCP family transcription factor
SwissprotQ9FTA21e-175TCP21_ARATH; Transcription factor TCP21
TrEMBLA0A178UQG91e-172A0A178UQG9_ARATH; TCP11
STRINGAT5G08330.11e-173(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM17822685
Representative plantOGRP85141016
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  3. Marsch-Martinez N, et al.
    BOLITA, an Arabidopsis AP2/ERF-like transcription factor that affects cell expansion and proliferation/differentiation pathways.
    Plant Mol. Biol., 2006. 62(6): p. 825-43
    [PMID:17096212]
  4. Aguilar-Martínez JA,Poza-Carrión C,Cubas P
    Arabidopsis BRANCHED1 acts as an integrator of branching signals within axillary buds.
    Plant Cell, 2007. 19(2): p. 458-72
    [PMID:17307924]
  5. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  6. Pruneda-Paz JL,Breton G,Para A,Kay SA
    A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock.
    Science, 2009. 323(5920): p. 1481-5
    [PMID:19286557]
  7. Mart
    TCP genes: a family snapshot ten years later.
    Trends Plant Sci., 2010. 15(1): p. 31-9
    [PMID:19963426]
  8. Viola IL,Uberti Manassero NG,Ripoll R,Gonzalez DH
    The Arabidopsis class I TCP transcription factor AtTCP11 is a developmental regulator with distinct DNA-binding properties due to the presence of a threonine residue at position 15 of the TCP domain.
    Biochem. J., 2011. 435(1): p. 143-55
    [PMID:21241251]
  9. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  10. Danisman S, et al.
    Analysis of functional redundancies within the Arabidopsis TCP transcription factor family.
    J. Exp. Bot., 2013. 64(18): p. 5673-85
    [PMID:24129704]
  11. Aguilar-Mart
    Analysis of the role of Arabidopsis class I TCP genes AtTCP7, AtTCP8, AtTCP22, and AtTCP23 in leaf development.
    Front Plant Sci, 2013. 4: p. 406
    [PMID:24137171]
  12. Kim SH, et al.
    The Arabidopsis immune adaptor SRFR1 interacts with TCP transcription factors that redundantly contribute to effector-triggered immunity.
    Plant J., 2014. 78(6): p. 978-89
    [PMID:24689742]
  13. Chen GH,Sun JY,Liu M,Liu J,Yang WC
    SPOROCYTELESS is a novel embryophyte-specific transcription repressor that interacts with TPL and TCP proteins in Arabidopsis.
    J Genet Genomics, 2014. 41(12): p. 617-25
    [PMID:25527103]
  14. Wu JF, et al.
    LWD-TCP complex activates the morning gene CCA1 in Arabidopsis.
    Nat Commun, 2016. 7: p. 13181
    [PMID:27734958]
  15. Ng DW,Chen HH,Chen ZJ
    Heterologous protein-DNA interactions lead to biased allelic expression of circadian clock genes in interspecific hybrids.
    Sci Rep, 2017. 7: p. 45087
    [PMID:28345627]
  16. Lee CM, et al.
    Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.
    Plant Physiol., 2018. 177(3): p. 1170-1186
    [PMID:29794020]