PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G64530.1
Common NameANAC104, MUB3.5, NAC104, XND1
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family NAC
Protein Properties Length: 187aa    MW: 21557.9 Da    PI: 4.6913
Description xylem NAC domain 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G64530.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM111.41e-3431181128
          NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlsk.kg 97 
                  lppGfrF Ptdeelvv++L++k++  +++  +vi+++d+y+++PwdLp k+ +e ++wyf+s++         ++r+t++gyW + g d++++++ ++
  AT5G64530.1   3 LPPGFRFFPTDEELVVHFLHRKASLLPCHP-DVIPDLDLYHYDPWDLPGKALGEGRQWYFYSRKT--------QERVTSNGYWGSMGMDEPIYTSsTH 91 
                  79*************************999.99***************87778899*****9975........5799****************98778 PP

          NAM  98 elvglkktLvfykgrapkgektdWvmheyrl 128
                  ++vg+kk L+fy g++    +t+W+m+ey+l
  AT5G64530.1  92 KKVGIKKYLTFYLGDS----QTNWIMQEYSL 118
                  88**********7654....68*******97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019415.62E-441155IPR003441NAC domain
PROSITE profilePS5100542.033155IPR003441NAC domain
PfamPF023655.0E-224118IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010089Biological Processxylem development
GO:0043067Biological Processregulation of programmed cell death
GO:0048367Biological Processshoot system development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0005352anatomyxylem
PO:0009005anatomyroot
PO:0009029anatomystamen
PO:0009030anatomycarpel
PO:0009046anatomyflower
PO:0009047anatomystem
PO:0020100anatomyhypocotyl
PO:0025281anatomypollen
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 187 aa     Download sequence    Send to blast
MNLPPGFRFF PTDEELVVHF LHRKASLLPC HPDVIPDLDL YHYDPWDLPG KALGEGRQWY  60
FYSRKTQERV TSNGYWGSMG MDEPIYTSST HKKVGIKKYL TFYLGDSQTN WIMQEYSLPD  120
SSSSSSRSSK RSSRASSSSH KPDYSKWVIC RVYEQNCSEE EDDDGTELSC LDEVFLSLDD  180
LDEVSLP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3swm_A3e-36116118174NAC domain-containing protein 19
3swm_B3e-36116118174NAC domain-containing protein 19
3swm_C3e-36116118174NAC domain-containing protein 19
3swm_D3e-36116118174NAC domain-containing protein 19
3swp_A3e-36116118174NAC domain-containing protein 19
3swp_B3e-36116118174NAC domain-containing protein 19
3swp_C3e-36116118174NAC domain-containing protein 19
3swp_D3e-36116118174NAC domain-containing protein 19
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.289540.0leaf
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO425687690.0
Genevisible247264_at0.0
Expression AtlasAT5G64530-
AtGenExpressAT5G64530-
ATTED-IIAT5G64530-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in root xylem vessels (PubMed:15923329). Expressed in stems, vascular tissue of cauline leaves and tracheary elements of sepals (PubMed:18069942). {ECO:0000269|PubMed:15923329, ECO:0000269|PubMed:18069942}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor that influences tracheary elements and xylem development by negatively regulating secondary cell wall fiber synthesis and programmed cell death. {ECO:0000269|PubMed:18069942, ECO:0000269|PubMed:20458494}.
Function -- GeneRIF ? help Back to Top
  1. Findings suggest that XND1 affects tracheary element growth through regulation of secondary wall synthesis and programmed cell death.
    [PMID: 18069942]
  2. XND1 harbors an apparently angiosperm-specific combination of interaction motifs potentially linking the general differentiation regulator RBR with a xylem-specific pathway for inhibition of differentiation.
    [PMID: 28742236]
  3. Study identifies XYLEM NAC DOMAIN 1 (XND1) as a key negative regulator of Arabidopsis root hydraulics at the species-wide level and reveals how genetic variation at XND1 may contribute to the trade-off between abiotic stress tolerance and biotic defense in Arabidopsis.
    [PMID: 30250259]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G64530.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Reduced plant height and length of tracheary elements in the stem. {ECO:0000269|PubMed:18069942}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G64530
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1187830.0AK118783.1 Arabidopsis thaliana At5g64530 mRNA for unknown protein, complete cds, clone: RAFL21-11-N14.
GenBankBT0257460.0BT025746.1 Arabidopsis thaliana At5g64530 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_201258.21e-137xylem NAC domain 1
SwissprotQ8GWK61e-138NC104_ARATH; NAC domain-containing protein 104
TrEMBLA0A178UC011e-136A0A178UC01_ARATH; XND1
STRINGAT5G64530.11e-136(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM36742862
Representative plantOGRP45101024
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Seki M, et al.
    Functional annotation of a full-length Arabidopsis cDNA collection.
    Science, 2002. 296(5565): p. 141-5
    [PMID:11910074]
  3. Ooka H, et al.
    Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana.
    DNA Res., 2003. 10(6): p. 239-47
    [PMID:15029955]
  4. Zhao C,Craig JC,Petzold HE,Dickerman AW,Beers EP
    The xylem and phloem transcriptomes from secondary tissues of the Arabidopsis root-hypocotyl.
    Plant Physiol., 2005. 138(2): p. 803-18
    [PMID:15923329]
  5. Truman W,de Zabala MT,Grant M
    Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance.
    Plant J., 2006. 46(1): p. 14-33
    [PMID:16553893]
  6. Thilmony R,Underwood W,He SY
    Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7.
    Plant J., 2006. 46(1): p. 34-53
    [PMID:16553894]
  7. Ko JH,Yang SH,Park AH,Lerouxel O,Han KH
    ANAC012, a member of the plant-specific NAC transcription factor family, negatively regulates xylary fiber development in Arabidopsis thaliana.
    Plant J., 2007. 50(6): p. 1035-48
    [PMID:17565617]
  8. Zhao C,Avci U,Grant EH,Haigler CH,Beers EP
    XND1, a member of the NAC domain family in Arabidopsis thaliana, negatively regulates lignocellulose synthesis and programmed cell death in xylem.
    Plant J., 2008. 53(3): p. 425-36
    [PMID:18069942]
  9. Price AM, et al.
    A comparison of leaf and petal senescence in wallflower reveals common and distinct patterns of gene expression and physiology.
    Plant Physiol., 2008. 147(4): p. 1898-912
    [PMID:18539778]
  10. Grant EH,Fujino T,Beers EP,Brunner AM
    Characterization of NAC domain transcription factors implicated in control of vascular cell differentiation in Arabidopsis and Populus.
    Planta, 2010. 232(2): p. 337-52
    [PMID:20458494]
  11. Zhao C, et al.
    XYLEM NAC DOMAIN1, an angiosperm NAC transcription factor, inhibits xylem differentiation through conserved motifs that interact with RETINOBLASTOMA-RELATED.
    New Phytol., 2017. 216(1): p. 76-89
    [PMID:28742236]
  12. Tang N, et al.
    Natural variation at XND1 impacts root hydraulics and trade-off for stress responses in Arabidopsis.
    Nat Commun, 2018. 9(1): p. 3884
    [PMID:30250259]