PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G67450.1
Common NameAZF1, K8K14.19, ZF1
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 245aa    MW: 26471 Da    PI: 7.8913
Description zinc-finger protein 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G67450.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H216.13.1e-0597119123
                  EEETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                  ykC+ CgksFs+   L  H  +H
  AT5G67450.1  97 YKCTVCGKSFSSYQALGGHKTSH 119
                  9***********99998888777 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576671.49E-996119No hitNo description
SMARTSM003550.002897119IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.604.5E-597119IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015711.21997124IPR007087Zinc finger, C2H2
PfamPF139129.2E-1497121IPR007087Zinc finger, C2H2
PROSITE patternPS00028099119IPR007087Zinc finger, C2H2
SuperFamilySSF576671.49E-9159186No hitNo description
SMARTSM003550.96164186IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.182164186IPR007087Zinc finger, C2H2
PfamPF139128.7E-11164188IPR007087Zinc finger, C2H2
PROSITE patternPS000280166186IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009409Biological Processresponse to cold
GO:0009738Biological Processabscisic acid-activated signaling pathway
GO:0010200Biological Processresponse to chitin
GO:0042538Biological Processhyperosmotic salinity response
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008270Molecular Functionzinc ion binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000003anatomywhole plant
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009005anatomyroot
PO:0009025anatomyvascular leaf
PO:0009029anatomystamen
PO:0009047anatomystem
PO:0020030anatomycotyledon
PO:0020038anatomypetiole
PO:0020100anatomyhypocotyl
PO:0025022anatomycollective leaf structure
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 245 aa     Download sequence    Send to blast
MALETLNSPT ATTTARPLLR YREEMEPENL EQWAKRKRTK RQRFDHGHQN QETNKNLPSE  60
EEYLALCLLM LARGSAVQSP PLPPLPSRAS PSDHRDYKCT VCGKSFSSYQ ALGGHKTSHR  120
KPTNTSITSG NQELSNNSHS NSGSVVINVT VNTGNGVSQS GKIHTCSICF KSFASGQALG  180
GHKRCHYDGG NNGNGNGSSS NSVELVAGSD VSDVDNERWS EESAIGGHRG FDLNLPADQV  240
SVTTS
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.65010.0root| seed
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306983070.0
Genevisible246993_at0.0
Expression AtlasAT5G67450-
AtGenExpressAT5G67450-
ATTED-IIAT5G67450-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Highly expressed in roots and at lower levels in leaves and stems. {ECO:0000269|PubMed:10806347, ECO:0000269|PubMed:15333755}.
Functional Description ? help Back to Top
Source Description
TAIREncodes zinc-finger protein. mRNA levels are elevated in response to low temperature, cold temperatures and high salt. The protein is localized to the nucleus and acts as a transcriptional repressor.
UniProtTranscriptional repressor involved in the inhibition of plant growth under abiotic stress conditions. Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner. {ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:21852415}.
Function -- GeneRIF ? help Back to Top
  1. AZF1 and AZF2 function as transcriptional repressors involved in the inhibition of plant growth under abiotic stress conditions.
    [PMID: 21852415]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00118ampDAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT5G67450.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By abscisic acid (ABA), ethylene, dehydration, salt and cold. {ECO:0000269|PubMed:10806347, ECO:0000269|PubMed:15333755, ECO:0000269|PubMed:21852415}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G67450
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0076450.0AB007645.1 Arabidopsis thaliana genomic DNA, chromosome 5, TAC clone:K8K14.
GenBankAY1233280.0AY123328.1 Arabidopsis thaliana zinc finger protein OZAKGYO (OZAKGYO) gene, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_201546.10.0zinc-finger protein 1
SwissprotQ9SSW10.0AZF1_ARATH; Zinc finger protein AZF1
TrEMBLA0A178UTI60.0A0A178UTI6_ARATH; ZF1
STRINGAT5G67450.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM31212264
Representative plantOGRP13115149
Publications ? help Back to Top
  1. Sakamoto H,Araki T,Meshi T,Iwabuchi M
    Expression of a subset of the Arabidopsis Cys(2)/His(2)-type zinc-finger protein gene family under water stress.
    Gene, 2000. 248(1-2): p. 23-32
    [PMID:10806347]
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
    [PMID:14593172]
  4. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  5. Sakamoto H, et al.
    Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions.
    Plant Physiol., 2004. 136(1): p. 2734-46
    [PMID:15333755]
  6. Truman W,de Zabala MT,Grant M
    Type III effectors orchestrate a complex interplay between transcriptional networks to modify basal defence responses during pathogenesis and resistance.
    Plant J., 2006. 46(1): p. 14-33
    [PMID:16553893]
  7. Thilmony R,Underwood W,He SY
    Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7.
    Plant J., 2006. 46(1): p. 34-53
    [PMID:16553894]
  8. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
    [PMID:17722694]
  9. Cartieaux F, et al.
    Simultaneous interaction of Arabidopsis thaliana with Bradyrhizobium Sp. strain ORS278 and Pseudomonas syringae pv. tomato DC3000 leads to complex transcriptome changes.
    Mol. Plant Microbe Interact., 2008. 21(2): p. 244-59
    [PMID:18184068]
  10. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
    [PMID:18650403]
  11. Kodaira KS, et al.
    Arabidopsis Cys2/His2 zinc-finger proteins AZF1 and AZF2 negatively regulate abscisic acid-repressive and auxin-inducible genes under abiotic stress conditions.
    Plant Physiol., 2011. 157(2): p. 742-56
    [PMID:21852415]
  12. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]