PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aan008031
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae; Artemisiinae; Artemisia
Family E2F/DP
Protein Properties Length: 230aa    MW: 25114.3 Da    PI: 9.5868
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Aan#S41963531PU_refUnigeneView CDS
PUT-183a-Artemisia_annua-159157PU_unrefplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP87.21.2e-27133198171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++ll+++e+g+++ln++a++L   dv  ++RRiYDi+NVLe+++liekk kn+irw+g
  Aan008031 133 RYDSSLGLLTKKFINLLKHAEDGVLDLNNAAETL---DV--QKRRIYDITNVLEGIGLIEKKLKNRIRWRG 198
                6899******************************...**..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.0E-29131200IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-34133198IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.44E-18133196IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023196.6E-25135198IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 230 aa     Download sequence    Send to blast
MAAPPSANGG GGQILQRRLP FTSTKPPFVP VDDYHRFNDV NRTDQQQQVV VVDEGITVKS  60
PQVKRKLGTA YNEVSSNEWG SVGYTTTISS PLHTPAKGGR GAGRPKGGKN KTAPQTPVSN  120
TGSPAPLTPG SCRYDSSLGL LTKKFINLLK HAEDGVLDLN NAAETLDVQK RRIYDITNVL  180
EGIGLIEKKL KNRIRWRGLD DSKPGELEND ISLLQAEVQK LSMEENRLDE
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-25129199274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024986430.11e-110transcription factor E2FA
SwissprotQ9FNY02e-69E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2U1Q3T41e-164A0A2U1Q3T4_ARTAN; Winged helix-turn-helix DNA-binding domain-containing protein
STRINGVIT_08s0007g02510.t012e-90(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.13e-67E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]