PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aan014100
Organism
Artemisia annua
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae; Artemisiinae; Artemisia
Family bHLH
Protein Properties Length: 260aa    MW: 28475.8 Da    PI: 9.1715
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-183a-Artemisia_annua-43326PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.84.1e-13178223454
                HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YIk+L
  Aan014100 178 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAILYIKEL 223
                799***********************6.....5****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088817.199174223IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.63E-14177227No hitNo description
SuperFamilySSF474591.3E-18177247IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.109.4E-19178245IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.6E-10178223IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003538.9E-16180229IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 260 aa     Download sequence    Send to blast
XHCRSMWLND PPPVSSGTTV NTVEMKDTGD VRAVVPPKET SVVPLNNSVH TENTTKSVVN  60
NSNHQGLSGS RELNFSSGFG CKPESVELVN FGESNKKKKA PALRGISEGG MMSFSSGMVV  120
PPSDTVKSGG VMSAADFDQS DIEASIGREV ESRLVVEPEK KATKTRRKPA NGREEPLNHV  180
EAERQRREKL NQRFYALRAV VPNVSKMDKA SLLGDAILYI KELKSKVDNT QCDKEELRNQ  240
LEALKKELLS KDSRQSSSSA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A1e-36172248278Transcription factor MYC2
5gnj_B1e-36172248278Transcription factor MYC2
5gnj_E1e-36172248278Transcription factor MYC2
5gnj_F1e-36172248278Transcription factor MYC2
5gnj_G1e-36172248278Transcription factor MYC2
5gnj_I1e-36172248278Transcription factor MYC2
5gnj_M1e-36172248278Transcription factor MYC2
5gnj_N1e-36172248278Transcription factor MYC2
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Highly expressed in trichomes and at lower levels in leaves and flowers (PubMed:24884371). Expressed at low levels in roots, stems, leaves, flowers and fruits (PubMed:15231736). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24884371}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in a number of promoters of jasmonate-induced genes (PubMed:15231736). Transcription activator involved in the transcriptional regulation of terpene biosynthesis in glandular trichomes (PubMed:24884371, PubMed:30518626). Binds to the promoter of the linalool synthase TPS5 and promotes TPS5 gene transactivation (PubMed:24884371). Acts synergistically with EOT1 in the transactivation of TPS5 (PubMed:24884371). Involved in type VI glandular trichome development (PubMed:30518626). Involved in the activation of terpene synthases required for volatile mono- and sesquiterpenes synthesis by the glandular cells of type VI trichomes (PubMed:30518626). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24884371, ECO:0000269|PubMed:30518626}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate and wounding. {ECO:0000269|PubMed:15231736}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024985985.16e-91transcription factor MYC2-like
SwissprotA0A060KY905e-65MYC1_SOLLC; Transcription factor MYC1
TrEMBLA0A2U1LJA41e-158A0A2U1LJA4_ARTAN; MYC2 transcription factor
STRINGXP_009609942.12e-70(Nicotiana tomentosiformis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-49bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Spyropoulou EA,Haring MA,Schuurink RC
    RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters.
    BMC Genomics, 2014. 15: p. 402
    [PMID:24884371]
  3. Xu J, et al.
    SlMYC1 Regulates Type VI Glandular Trichome Formation and Terpene Biosynthesis in Tomato Glandular Cells.
    Plant Cell, 2018. 30(12): p. 2988-3005
    [PMID:30518626]