PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aqcoe2G399200.2.p
Organism
Aquilegia coerulea
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Ranunculales; Ranunculaceae; Thalictroideae; Aquilegia
Family bHLH
Protein Properties Length: 378aa    MW: 42323.7 Da    PI: 5.0691
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Aqcoe2G399200.2.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH38.22.5e-12168219155
                        CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                        +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i   A+e++++L+
  Aqcoe2G399200.2.p 168 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 219
                        79****************************...9*****************9995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000835.33E-13166223No hitNo description
Gene3DG3DSA:4.10.280.101.3E-13166222IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088815.428167218IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474597.2E-17167239IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.2E-9168219IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.4E-9173224IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048730.00361303367No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010377Biological Processguard cell fate commitment
GO:0045597Biological Processpositive regulation of cell differentiation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051782Biological Processnegative regulation of cell division
GO:0005634Cellular Componentnucleus
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 378 aa     Download sequence    Send to blast
MNKPRIGDIS GENNNIAMVD YMFNNPPQQQ LSSSFGTSTS LDKLNFADVM QFADFGPKLA  60
LNQTKTTEEE NGIDPVYFLK FPVLNDRSQD QNLINAPLTG YNGNEFDEVS VGRNVTSLVE  120
EEEPHVSENN SMQLGFLGGT SLQKNPGSEV KKRKRPRSVK TTEEVESQRM THIAVERNRR  180
KQMNEHLRVL RSLMPGSYVQ RGDQASIIGG AIEFVRELEQ LLQCLESQKR RRLYGNGEAP  240
RPMGDPNSLP IQQPQPPLFP PMPSPTDQIK FGEYDDTGLL EETAENKSFL ADVEVKVLGF  300
DALIKILSRR RPGQLIKTIA ALEDLQFNIL HTNITTIEQT VLYSFNVKVA SESRFTAEDI  360
ASSVQQIFTF IHASSTL*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1168179RMTHIAVERNRR
2228232KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021641448.10.0transcription factor FAMA-like isoform X1
RefseqXP_021641449.10.0transcription factor FAMA-like isoform X2
RefseqXP_021641450.10.0transcription factor FAMA-like isoform X2
SwissprotQ56YJ81e-141FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A2G5CXN40.0A0A2G5CXN4_AQUCA; Uncharacterized protein
STRINGAquca_034_00130.10.0(Aquilegia coerulea)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-129bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]