PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aqcoe5G188900.2.p
Organism
Aquilegia coerulea
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Ranunculales; Ranunculaceae; Thalictroideae; Aquilegia
Family bHLH
Protein Properties Length: 428aa    MW: 47517 Da    PI: 5.754
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Aqcoe5G188900.2.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.75.6e-10237284455
                        HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                        +h+ +Er RR++i +++  L++l+P +    +k   Ka +L + ++Y++sLq
  Aqcoe5G188900.2.p 237 SHSLAERVRREKISERMKYLQDLVPGC----NKITGKAGMLDEIINYVQSLQ 284
                        8**************************....999*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474596.28E-17231302IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000833.19E-10231288No hitNo description
PROSITE profilePS5088815.618233283IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.103.7E-17233300IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.3E-7237284IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.3E-9239289IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 428 aa     Download sequence    Send to blast
MLHCAADTMT VLERQQARQK WQQVPLLQQQ QQQQQQHQQS YFSDTHFNLL PNSSSSSQQF  60
HIMMNDDSVI RDFVNRSIKL DPSLDNNGWQ DFGKYPVSGN GFGGEINGFG VNGVDLVDYS  120
LSRTSSCPPE DVVVEAKGGE VVVAEKLGGK VGKESFKKRK AQNSKVVAEE VIRDKRMKGD  180
SEEESKVTEV NNSNSSTSNN NNKETSGDSV KENSKASGAQ KQDYIHVRAR RGQATDSHSL  240
AERVRREKIS ERMKYLQDLV PGCNKITGKA GMLDEIINYV QSLQRQVEFL SMKLAAVNPR  300
LDFNIENLFA KEMFSANTAG FPIGTSSEMA NPSAYLPLNS LQQMISNCGL DMGMNSSDIS  360
LQRTRSAPVS DAFLDTSCFT QAQPSSSAWE TDLQSLYNVE FNQTRPVTFP PQSFTGILEA  420
NNLKMEM*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT1405841e-61BT140584.1 Medicago truncatula clone JCVI-FLMt-18N21 unknown mRNA.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018851563.11e-153PREDICTED: transcription factor bHLH63-like
SwissprotQ8GY612e-60BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A2G5EJ370.0A0A2G5EJ37_AQUCA; Uncharacterized protein
STRINGAquca_007_00236.10.0(Aquilegia coerulea)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G34530.14e-58cryptochrome-interacting basic-helix-loop-helix 1
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]