PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Araha.1448s0012.1.p

Organism

Arabidopsis halleri

Taxonomic ID

81970

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

MYB

Protein Properties

Length: 372aa MW: 41591 Da PI: 5.9398

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Araha.1448s0012.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	57	4.4e-18	14	61	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g+WTteEd++l+ +++ +G g W+ I+++ g++R++k+c++rw +yl Araha.1448s0012.1.p 14 KGAWTTEEDKKLISYIHDHGEGGWRDIPQKAGLKRCGKSCRLRWTNYL 61 79********************************************97 PP
2	Myb_DNA-binding	48	2.8e-15	67	112	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 rg ++ eE+++++ +++ G++ W+ Iar+++ +Rt++++k++w+++l Araha.1448s0012.1.p 67 RGEFSSEEEQIIIMLHASRGNK-WSVIARHLP-RRTDNEIKNYWNTHL 112 899*****************.*****.**********996 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.60	6.0E-24	5	64	IPR009057	Homeodomain-like
PROSITE profile	PS51294	17.579	9	61	IPR017930	Myb domain
SuperFamily	SSF46689	2.47E-28	11	108	IPR009057	Homeodomain-like
SMART	SM00717	3.6E-14	13	63	IPR001005	SANT/Myb domain
Pfam	PF00249	1.1E-16	14	61	IPR001005	SANT/Myb domain
CDD	cd00167	4.94E-11	16	61	No hit	No description
PROSITE profile	PS51294	24.196	62	116	IPR017930	Myb domain
Gene3D	G3DSA:1.10.10.60	5.4E-25	65	117	IPR009057	Homeodomain-like
SMART	SM00717	2.5E-14	66	114	IPR001005	SANT/Myb domain
Pfam	PF00249	1.4E-13	67	112	IPR001005	SANT/Myb domain
CDD	cd00167	1.30E-10	69	112	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009625	Biological Process	response to insect
GO:0009682	Biological Process	induced systemic resistance
GO:0009739	Biological Process	response to gibberellin
GO:0009751	Biological Process	response to salicylic acid
GO:0009753	Biological Process	response to jasmonic acid
GO:0010439	Biological Process	regulation of glucosinolate biosynthetic process
GO:0050832	Biological Process	defense response to fungus
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 372 aa Download sequence Send to blast
MSRKPCCVGE GLKKGAWTTE EDKKLISYIH DHGEGGWRDI PQKAGLKRCG KSCRLRWTNY 60 LKPEIKRGEF SSEEEQIIIM LHASRGNKWS VIARHLPRRT DNEIKNYWNT HLKKRLIEQG 120 LDPVTHKPLA SSSNPTVDEN LNSLNDSSSD KQYSRSSSMP TLSRPLPSSC NMVSKVSEIS 180 SNDGTPVQGS SLSCKKRFKK SSSTSRLLNK VAAKATSIKD ILSASMEGSL SATTMSHASF 240 FNGFTEQIRN GEDSSNTSLT NTLAEFDPLS PSSLYPEHEI NATSDLNMDQ DFDFSQFFEK 300 LGGDNHNEEN SMNVEYSHDL LLSDVSQEVS STSVDDQDNM VGNFEGWSNY LLDHTNFMYD 360 TDSDSLEKHF I*

Sequence ? help Back to Top

Protein Sequence Length: 372 aa Download sequence Send to blast

MSRKPCCVGE GLKKGAWTTE EDKKLISYIH DHGEGGWRDI PQKAGLKRCG KSCRLRWTNY  60
LKPEIKRGEF SSEEEQIIIM LHASRGNKWS VIARHLPRRT DNEIKNYWNT HLKKRLIEQG  120
LDPVTHKPLA SSSNPTVDEN LNSLNDSSSD KQYSRSSSMP TLSRPLPSSC NMVSKVSEIS  180
SNDGTPVQGS SLSCKKRFKK SSSTSRLLNK VAAKATSIKD ILSASMEGSL SATTMSHASF  240
FNGFTEQIRN GEDSSNTSLT NTLAEFDPLS PSSLYPEHEI NATSDLNMDQ DFDFSQFFEK  300
LGGDNHNEEN SMNVEYSHDL LLSDVSQEVS STSVDDQDNM VGNFEGWSNY LLDHTNFMYD  360
TDSDSLEKHF I*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1a5j_A	1e-24	12	116	5	108	B-MYB
1h8a_C	1e-24	12	116	25	128	MYB TRANSFORMING PROTEIN
1mse_C	9e-25	12	116	2	105	C-Myb DNA-Binding Domain
1msf_C	9e-25	12	116	2	105	C-Myb DNA-Binding Domain
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Functional Description ? help Back to Top
Source	Description
UniProt	Major regulator of short-chained aliphatic glucosinolates (GLSs) biosynthesis. Together with MYB29/HAG3 and MYB76/HAG2, promotes aliphatic glucosinolate biosynthesis but represses indolic glucosinolate biosynthesis. Prevents insect performance (e.g. lepidopteran insect Mamestra brassicae and Spodoptera exigua) by promoting glucosinolates. {ECO:0000269\|PubMed:17420480, ECO:0000269\|PubMed:17521412, ECO:0000269\|PubMed:18042203, ECO:0000269\|PubMed:18446225, ECO:0000269\|PubMed:20348214, ECO:0000269\|PubMed:23580754, ECO:0000269\|PubMed:23792303, ECO:0000269\|PubMed:23943862}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Araha.1448s0012.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Slightly induced by glucose, gibberellic acid (GA), jasmonic acid (JA) and salicylic acid (SA). Transiently induced in inflorescence by mechanical stimuli such as touch or wounding, including herbivory-wounding. Up-regulated by sulfur-deficient stress. {ECO:0000269\|PubMed:16463103, ECO:0000269\|PubMed:17521412, ECO:0000269\|PubMed:23115560, ECO:0000269\|PubMed:23792303}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF175998	0.0	AF175998.1 Arabidopsis thaliana putative transcription factor (MYB28) mRNA, complete cds.
GenBank	AY519643	0.0	AY519643.1 Arabidopsis thaliana MYB transcription factor (At5g61420) mRNA, complete cds.
GenBank	BT028959	0.0	BT028959.1 Arabidopsis thaliana At5g61420 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_002866434.1	0.0	transcription factor MYB28
Swissprot	Q9SPG2	0.0	MYB28_ARATH; Transcription factor MYB28
TrEMBL	D7MV18	0.0	D7MV18_ARALL; Uncharacterized protein
STRING	scaffold_802785.1	0.0	(Arabidopsis lyrata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM3787	18	60

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G61420.2	0.0	myb domain protein 28

Link Out ? help Back to Top
Phytozome	Araha.1448s0012.1.p

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Kim K,Jiang K,Teng SL,Feldman LJ,Huang H Using biologically interrelated experiments to identify pathway genes in Arabidopsis. Bioinformatics, 2012. 28(6): p. 815-22 [PMID:22271267] Augustine R,Majee M,Gershenzon J,Bisht NC Four genes encoding MYB28, a major transcriptional regulator of the aliphatic glucosinolate pathway, are differentially expressed in the allopolyploid Brassica juncea. J. Exp. Bot., 2013. 64(16): p. 4907-21 [PMID:24043856] Guo R, et al. Jasmonic acid and glucose synergistically modulate the accumulation of glucosinolates in Arabidopsis thaliana. J. Exp. Bot., 2013. 64(18): p. 5707-19 [PMID:24151308] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Li F, et al. Genome-wide association study dissects the genetic architecture of seed weight and seed quality in rapeseed (Brassica napus L.). DNA Res., 2014. 21(4): p. 355-67 [PMID:24510440] Frerigmann H,Gigolashvili T Update on the role of R2R3-MYBs in the regulation of glucosinolates upon sulfur deficiency. Front Plant Sci, 2014. 5: p. 626 [PMID:25426131] Burow M, et al. The Glucosinolate Biosynthetic Gene AOP2 Mediates Feed-back Regulation of Jasmonic Acid Signaling in Arabidopsis. Mol Plant, 2015. 8(8): p. 1201-12 [PMID:25758208] Martínez-Ballesta M, et al. The impact of the absence of aliphatic glucosinolates on water transport under salt stress in Arabidopsis thaliana. Front Plant Sci, 2015. 6: p. 524 [PMID:26236322] Seo MS, et al. Functional analysis of three BrMYB28 transcription factors controlling the biosynthesis of glucosinolates in Brassica rapa. Plant Mol. Biol., 2016. 90(4-5): p. 503-16 [PMID:26820138] Bulgakov VP,Veremeichik GN,Grigorchuk VP,Rybin VG,Shkryl YN The rolB gene activates secondary metabolism in Arabidopsis calli via selective activation of genes encoding MYB and bHLH transcription factors. Plant Physiol. Biochem., 2016. 102: p. 70-9 [PMID:26913794] Mostafa I, et al. New nodes and edges in the glucosinolate molecular network revealed by proteomics and metabolomics of Arabidopsis myb28/29 and cyp79B2/B3 glucosinolate mutants. J Proteomics, 2016. 138: p. 1-19 [PMID:26915584] Smith JD,Woldemariam MG,Mescher MC,Jander G,De Moraes CM Glucosinolates from Host Plants Influence Growth of the Parasitic Plant Cuscuta gronovii and Its Susceptibility to Aphid Feeding. Plant Physiol., 2016. 172(1): p. 181-97 [PMID:27482077] Aarabi F, et al. Sulfur deficiency-induced repressor proteins optimize glucosinolate biosynthesis in plants. Sci Adv, 2016. 2(10): p. e1601087 [PMID:27730214] Mostafa I, et al. Membrane Proteomics of Arabidopsis Glucosinolate Mutants cyp79B2/B3 and myb28/29. Front Plant Sci, 2017. 8: p. 534 [PMID:28443122] Simon MK,Skinner DJ,Gallagher TL,Gasser CS Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors. Genetics, 2017. 207(4): p. 1489-1500 [PMID:28971961] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470]