PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla008805
Organism
Citrullus lanatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family bHLH
Protein Properties Length: 656aa    MW: 72024.5 Da    PI: 6.1804
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla008805genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.31.1e-12473518454
                HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  Av YI++L
  Cla008805 473 NHVEAERQRREKLNQKFYALRAVVPNV-----SKMDKASLLGDAVSYINEL 518
                799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.6E-5573253IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.161469518IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.86E-15472523No hitNo description
SuperFamilySSF474596.28E-18472539IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.2E-10473518IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.104.4E-17473539IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.1E-16475524IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 656 aa     Download sequence    Send to blast
MTDYRLSTMN LWTDENASVM DAFMNSDLSS YWAPSAASSH SLHHPPPPQS SASTSTPPPD  60
PPKSLPVFNQ ETLQQRLQAL IDGARESWTY AIFWQSSYDY SGASVLGWGD GYYKGEEDKG  120
KGKAKMVSSA AEQAHRKKVL RELNSLISGS AAGPDDAVDE EVTDTEWFFL VSMTQSFDNG  180
VWLPSQAFYN STPIWVSGAD RLSASACERA RQGRVFGLQT MVCIPSPNGV VEMGSTELIH  240
RTSDLMNKVK ILFNFNNLET SSWISGTTAA DEGENDPSSM WISEPSSTIE MKDSITTTVP  300
SGNVPAKPIH SENPSSSSLT ENISAIQQPS HQKQSQSFLN FSDYGFESNP SKNTTAAATT  360
TTATPSFKPE SGGMLNFGNG NLFSSHSQYV TNEQNEKKRS PASRSSNDEG ILSFTSGVIL  420
PSSGKVKSGD SDHSDLEASV IREVDSCTKS LEPEKRPRKR GRKPANGREE PLNHVEAERQ  480
RREKLNQKFY ALRAVVPNVS KMDKASLLGD AVSYINELKS KLQIAETEKT EMGKHLELLK  540
KEMGGKDFGN YPNPNDEDLK IGKRKVMDME IEVKIMGWDA MIRIQSSKKN HPAARLMAAF  600
KDLDLEMLHA SVSVVNDLMI QQATVKMGSR FYTQEQLKMA LVARVGGGGG SSHGMM
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A1e-75662562195Transcription factor MYC3
4rqw_B1e-75662562195Transcription factor MYC3
4rs9_A1e-75662562195Transcription factor MYC3
4yz6_A1e-75662562195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1454462KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818600.0LN681860.1 Cucumis melo genomic scaffold, anchoredscaffold00021.
GenBankLN7132600.0LN713260.1 Cucumis melo genomic chromosome, chr_6.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004148739.10.0PREDICTED: transcription factor MYC2-like
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A0A0L3Z00.0A0A0A0L3Z0_CUCSA; Transcription factor AtMYC2
STRINGXP_004164415.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF29383364
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-178bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]