PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Cla013146

Organism

Citrullus lanatus

Taxonomic ID

3654

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus

Family

HD-ZIP

Protein Properties

Length: 710aa MW: 79039 Da PI: 6.688

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Cla013146	genome	ICuGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	61	1.8e-19	28	83	1	56
TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 +++ ++++++q+++Le++F+ +++p++++r++L+++lgL+++q+k+WFqN+R++ k Cla013146 28 KKTYHRHNPYQIQQLESFFRACPHPDENQRRQLSQELGLETKQIKFWFQNKRTQTK 83 688999**********************************************9987 PP
2	START	136.1	3.9e-43	227	447	3	206
HHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS............SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEEECT CS START 3 aeeaaqelvkkalaeepgWvkssesengdevlqkfeeskv...........dsgealrasgvvdmvlallveellddkeqWdetla....kaetleviss 87 a +a++el+++ +ep+W+k ++g +vl +++ +k ++e ++asgvv+m + +lv +ld +W ++ a+t i++ Cla013146 227 AATALEELIRLLRIDEPLWMKTL--NDGRYVLHRESYDKIfprpnhfksssARTESSKASGVVTMSAIQLVDFFLDAD-KWADLFPtiimNADTFHIIDP 323 67899****************..888888888877777788888999999***************9999999.**99999****** PP T......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXX.HH CS START 88 g......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlkgrlp.hw 179 g galqlm++++ splv+ Rdf f+R+++q + g+wvivdvS + ++ + ++R+ +lpSg+li++++ng sk+twvehv++++++ h Cla013146 324 GmpgnrsGALQLMYQQMHIFSPLVSpRDFCFLRHCQQIELGVWVIVDVSYEILKDCVT---SARCWRLPSGCLIQEMPNGCSKITWVEHVEVDDKTQtHR 420 ******************9999********************98888775...8****************************9998 PP HHHHHHHHHHHHHHHHHHHHTXXXXXX CS START 180 llrslvksglaegaktwvatlqrqcek 206 l+r lv ++la ga +w+ tlqr ce+ Cla013146 421 LYRDLVFNTLAYGADRWFFTLQRMCER 447 *************************97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.60	2.1E-20	13	79	IPR009057	Homeodomain-like
SuperFamily	SSF46689	8.36E-19	14	86	IPR009057	Homeodomain-like
PROSITE profile	PS50071	16.568	25	85	IPR001356	Homeobox domain
SMART	SM00389	1.6E-16	27	89	IPR001356	Homeobox domain
Pfam	PF00046	5.8E-17	28	83	IPR001356	Homeobox domain
CDD	cd00086	1.40E-16	28	86	No hit	No description
PROSITE pattern	PS00027	0	60	83	IPR017970	Homeobox, conserved site
PROSITE profile	PS50848	44.133	216	450	IPR002913	START domain
SuperFamily	SSF55961	1.02E-32	218	449	No hit	No description
CDD	cd08875	1.41E-104	221	446	No hit	No description
SMART	SM00234	1.6E-30	225	447	IPR002913	START domain
Pfam	PF01852	3.4E-36	227	447	IPR002913	START domain
Gene3D	G3DSA:3.30.530.20	2.4E-10	270	411	IPR023393	START-like domain
SuperFamily	SSF55961	1.07E-12	468	642	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0008289	Molecular Function	lipid binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 710 aa Download sequence Send to blast
MDYMMDGRGG YGGGSTDEQE GSNDRKGKKT YHRHNPYQIQ QLESFFRACP HPDENQRRQL 60 SQELGLETKQ IKFWFQNKRT QTKAQNERAD NSSLRTENEK IQCENLAIRE ALRNVICPSC 120 GGPPFGEEER QRNLQKLRLE NSHLKEEHDK VSNLLAKYIG KPISQLESLL PVLGSSIDLS 180 PRSSLTQIVA SPAVDLISDP VILDGAATPY QSRGINDLEN ALMLETAATA LEELIRLLRI 240 DEPLWMKTLN DGRYVLHRES YDKIFPRPNH FKSSSARTES SKASGVVTMS AIQLVDFFLD 300 ADKWADLFPT IIMNADTFHI IDPGMPGNRS GALQLMYQQM HIFSPLVSPR DFCFLRHCQQ 360 IELGVWVIVD VSYEILKDCV TSARCWRLPS GCLIQEMPNG CSKITWVEHV EVDDKTQTHR 420 LYRDLVFNTL AYGADRWFFT LQRMCERLAY TFRDCAPSHE LGGVLTSPEG RRSITKLSHR 480 MVKNFCGVLS MSGKLDFPQL SEVNNSGVRI SVRISSELGQ PSGTVVSAAT SLWLPLQPEI 540 IFNFFRDEKA RVQWDVLSYG NPVHEIAHIL TGVHPGNSIS IIRPFVPTEN NMLILQESCI 600 DPLGSLVIYA PIDLPAMNIA TSGQDPSGIP ILPSGFVITG DGRMHSGIGA STSATSGRPS 660 GSLLTIAFQI LVSSVSSSKQ LNVESVATVN TLISATVQRI KAALNCSGLD

Sequence ? help Back to Top

Protein Sequence Length: 710 aa Download sequence Send to blast

MDYMMDGRGG YGGGSTDEQE GSNDRKGKKT YHRHNPYQIQ QLESFFRACP HPDENQRRQL  60
SQELGLETKQ IKFWFQNKRT QTKAQNERAD NSSLRTENEK IQCENLAIRE ALRNVICPSC  120
GGPPFGEEER QRNLQKLRLE NSHLKEEHDK VSNLLAKYIG KPISQLESLL PVLGSSIDLS  180
PRSSLTQIVA SPAVDLISDP VILDGAATPY QSRGINDLEN ALMLETAATA LEELIRLLRI  240
DEPLWMKTLN DGRYVLHRES YDKIFPRPNH FKSSSARTES SKASGVVTMS AIQLVDFFLD  300
ADKWADLFPT IIMNADTFHI IDPGMPGNRS GALQLMYQQM HIFSPLVSPR DFCFLRHCQQ  360
IELGVWVIVD VSYEILKDCV TSARCWRLPS GCLIQEMPNG CSKITWVEHV EVDDKTQTHR  420
LYRDLVFNTL AYGADRWFFT LQRMCERLAY TFRDCAPSHE LGGVLTSPEG RRSITKLSHR  480
MVKNFCGVLS MSGKLDFPQL SEVNNSGVRI SVRISSELGQ PSGTVVSAAT SLWLPLQPEI  540
IFNFFRDEKA RVQWDVLSYG NPVHEIAHIL TGVHPGNSIS IIRPFVPTEN NMLILQESCI  600
DPLGSLVIYA PIDLPAMNIA TSGQDPSGIP ILPSGFVITG DGRMHSGIGA STSATSGRPS  660
GSLLTIAFQI LVSSVSSSKQ LNVESVATVN TLISATVQRI KAALNCSGLD

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269\|PubMed:16778018, ECO:0000269\|PubMed:18451323, ECO:0000269\|PubMed:23095885, ECO:0000269\|PubMed:24821957, ECO:0000269\|PubMed:24824485, ECO:0000269\|PubMed:25564655, ECO:0000269\|PubMed:25752924}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	LN681854	0.0	LN681854.1 Cucumis melo genomic scaffold, anchoredscaffold00042.
GenBank	LN713260	0.0	LN713260.1 Cucumis melo genomic chromosome, chr_6.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004140733.2	0.0	PREDICTED: homeobox-leucine zipper protein HDG11 isoform X2
Swissprot	Q9FX31	0.0	HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBL	A0A0A0L656	0.0	A0A0A0L656_CUCSA; Uncharacterized protein
STRING	XP_004140733.1	0.0	(Cucumis sativus)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1026	33	98

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G73360.1	0.0	homeodomain GLABROUS 11

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Khosla A, et al. HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23. Plant Cell, 2014. 26(5): p. 2184-2200 [PMID:24824485] Horstman A, et al. AIL and HDG proteins act antagonistically to control cell proliferation. Development, 2015. 142(3): p. 454-64 [PMID:25564655] Cai XT,Xu P,Wang Y,Xiang CB Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis. J Integr Plant Biol, 2015. 57(12): p. 1017-30 [PMID:25752924] Yu LH, et al. Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field. Plant Biotechnol. J., 2016. 14(1): p. 72-84 [PMID:25879154] Zhu Z, et al. Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance. Front Plant Sci, 2016. 7: p. 1285 [PMID:27625663] Liu Y, et al. Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza. Protoplasma, 2017. 254(4): p. 1617-1625 [PMID:27915455] Ueda M, et al. Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote. Genes Dev., 2017. 31(6): p. 617-627 [PMID:28404632] Lung SC, et al. Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors. New Phytol., 2018. 218(1): p. 183-200 [PMID:29288621] Zheng G, et al. Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.). Front Plant Sci, 2017. 8: p. 2125 [PMID:29326737]