PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla018652
Organism
Citrullus lanatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family HD-ZIP
Protein Properties Length: 705aa    MW: 78489.9 Da    PI: 6.8396
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla018652genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox61.31.4e-192176156
               TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
   Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
               +++ ++++++q+++Le++F+++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  Cla018652 21 KKRYHRHNANQIQRLEAMFKECPHPDEKQRLQLSRELGLAPRQIKFWFQNRRTQMK 76
               6778999**********************************************998 PP
2START183.89.5e-582194432206
                HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEEEEECT CS
      START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....kaetleviss 87 
                +a  a++el+++ + +ep+W+ks+    + ++ +++ q f++ ++      +++ea+r+sgvv+m +a lv +++d++ +W+e ++     a t+eviss
  Cla018652 219 IATNAMAELLRLSQTNEPFWMKSPtdgrDLLDLETYEQAFPRPNTplknlhFRTEASRDSGVVIMSSAALVDIFMDSN-KWTELFPtivsIARTIEVISS 317
                77899********************999999999999***999889********************************.*******999999******** PP

                T......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXX.HH CS
      START  88 g......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlkgrlp.hw 179
                g      g lqlm++elq+lsplvp R f+++Ry++q ++g+w++vdvS + +++++   s   ++++pSg+li++++ng+skvtw+ehv++++r   hw
  Cla018652 318 GmlgsqnGSLQLMYQELQLLSPLVPtRHFYVLRYCQQIEQGVWAVVDVSYNIPRENQI-VSHSQCHRFPSGCLIQDMPNGYSKVTWIEHVEVEDRGStHW 416
                ********************************************************95.778889******************************999** PP

                HHHHHHHHHHHHHHHHHHHHTXXXXXX CS
      START 180 llrslvksglaegaktwvatlqrqcek 206
                l+r l++sgla+ga +w+atlqr  e+
  Cla018652 417 LFRDLIHSGLAFGAERWLATLQRMAER 443
                **********************98875 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.604.9E-22672IPR009057Homeodomain-like
SuperFamilySSF466899.19E-20778IPR009057Homeodomain-like
PROSITE profilePS5007117.7671878IPR001356Homeobox domain
SMARTSM003891.5E-181982IPR001356Homeobox domain
CDDcd000864.25E-182079No hitNo description
PfamPF000463.6E-172176IPR001356Homeobox domain
PROSITE patternPS0002705376IPR017970Homeobox, conserved site
PROSITE profilePS5084847.171209446IPR002913START domain
SuperFamilySSF559615.91E-36212444No hitNo description
CDDcd088753.99E-114213442No hitNo description
SMARTSM002342.0E-50218443IPR002913START domain
PfamPF018522.5E-49219442IPR002913START domain
Gene3DG3DSA:3.30.530.203.2E-7278442IPR023393START-like domain
SuperFamilySSF559611.65E-22464697No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 705 aa     Download sequence    Send to blast
MDFGGGSGWD NDSSSDPQRR KKRYHRHNAN QIQRLEAMFK ECPHPDEKQR LQLSRELGLA  60
PRQIKFWFQN RRTQMKAQHE RADNSALRAE NDKIRCENIA IREALKNVIC PSCGGPPLQD  120
PYFDEHKLRI ENSHLKEELD RLSSIAAKYI GRPISQLPPI QPSHFSSLEL SMGSFPSQEM  180
GCPSLDLDLL PASSTSVTSL PYLHPIHLSS VDKSLMTEIA TNAMAELLRL SQTNEPFWMK  240
SPTDGRDLLD LETYEQAFPR PNTPLKNLHF RTEASRDSGV VIMSSAALVD IFMDSNKWTE  300
LFPTIVSIAR TIEVISSGML GSQNGSLQLM YQELQLLSPL VPTRHFYVLR YCQQIEQGVW  360
AVVDVSYNIP RENQIVSHSQ CHRFPSGCLI QDMPNGYSKV TWIEHVEVED RGSTHWLFRD  420
LIHSGLAFGA ERWLATLQRM AERFACLMVT GSSNQDLSGV IPSPEGKRSM MKLAQRMVNN  480
FCASISTSHG HRWTTLSGMN EVGVRVTVHK STDSGQPNGV VLSAATTIWL PVYPQTIFNF  540
FKNDRTRSQW DVLSDGNPVQ EVAHISNGSH PGNCISVLRA FNTSQNNMLI LQESCIDSSG  600
SLVVYCPVDL PAMNVAMSGE DPSSIPLLPS GFTILPDGRR DQGEGTSSSS DVNNRSGGSL  660
VTVAFQILVS SLPSGKLNLE SVTTVNNLIS TTVHQIKTAL NCHSS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6819320.0LN681932.1 Cucumis melo genomic scaffold, anchoredscaffold00001.
GenBankLN7132660.0LN713266.1 Cucumis melo genomic chromosome, chr_12.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016898817.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1S4DS380.0A0A1S4DS38_CUCME; homeobox-leucine zipper protein HDG11-like
STRINGXP_008445879.10.0(Cucumis melo)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]