PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cla022941
Organism
Citrullus lanatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Citrullus
Family C2H2
Protein Properties Length: 323aa    MW: 36798.9 Da    PI: 6.0356
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cla022941genomeICuGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.60.0004279101323
                ET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                C+   Cgk+F +   L++H   H
  Cla022941  79 CSyeGCGKTFIDAGALRKHSHIH 101
                77779**************7766 PP
2zf-C2H216.72e-05106130123
                EEET..TTTEEESSHHHHHHHHHHT CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                y+C+   Cgk F ++s LkrH   H
  Cla022941 106 YVCHyeGCGKKFLDSSKLKRHFLIH 130
                9********************8877 PP
3zf-C2H214.10.00014181206123
                EEET..TTTEEESSHHHHHHHHHH.T CS
    zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                y Cp   C k + + + Lk H+r+ H
  Cla022941 181 YACPyeGCEKAYIHEYKLKLHLRReH 206
                89**********************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.607.7E-1472103IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.78377106IPR007087Zinc finger, C2H2
SMARTSM003550.003277101IPR015880Zinc finger, C2H2-like
SuperFamilySSF576671.9E-678102No hitNo description
PROSITE patternPS00028079101IPR007087Zinc finger, C2H2
SuperFamilySSF576674.16E-10101143No hitNo description
Gene3DG3DSA:3.30.160.601.9E-14104126IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015713.921106135IPR007087Zinc finger, C2H2
SMARTSM003550.0024106130IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280108130IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.601.0E-9127145IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
Gene3DG3DSA:3.30.160.601.8E-9175204IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576677.59E-6176204No hitNo description
PROSITE profilePS501579.328181208IPR007087Zinc finger, C2H2
SMARTSM003550.0089181206IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280183206IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 323 aa     Download sequence    Send to blast
METHYNHNLF DRRPIVKNKS PPVKWIKEWV PQDVVATGGK CFLLKWVPED TLKALKEKAK  60
QSEAPEPEPE PTTEVLFLCS YEGCGKTFID AGALRKHSHI HGERQYVCHY EGCGKKFLDS  120
SKLKRHFLIH TGERDFVCPH EGCGKNVTAE VVKYTPPSEK QTKVSKPSGG AYASASSDRP  180
YACPYEGCEK AYIHEYKLKL HLRREHPGHL VEDNGNAPHN GENEVEASDQ DGYGGKRANV  240
KNQKQNKPKP NLKLPPSKMS QRKGTTTPSP APMNAVKKSW PVKEENYEEE DSEETEEEDR  300
ENVEEGWRYA ENEDDDEETE YED
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C3e-25792028114PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818960.0LN681896.1 Cucumis melo genomic scaffold, anchoredscaffold00016.
GenBankLN7132640.0LN713264.1 Cucumis melo genomic chromosome, chr_10.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011655546.10.0PREDICTED: uncharacterized zinc finger protein At4g06634
SwissprotQ2V3L31e-109YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A0A0KT980.0A0A0A0KT98_CUCSA; Uncharacterized protein
STRINGXP_004161926.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF56493354
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-97C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]