PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.034450.1
Common NameCsa_5G387970, LOC101217824
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family C2H2
Protein Properties Length: 449aa    MW: 51803.1 Da    PI: 7.359
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.034450.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.90.00069206228123
                     EEETTTTEEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                     y C+ C    +rk++L+rH+r++
  Cucsa.034450.1 206 YFCEFCLNFMKRKEQLQRHMRKC 228
                     78*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541601.92E-2355173IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2707.1E-3758133No hitNo description
PfamPF117175.7E-2063121IPR025995RNA binding activity-knot of a chromodomain
CDDcd000241.67E-676122No hitNo description
SMARTSM002983.1E-577136IPR000953Chromo/chromo shadow domain
Gene3DG3DSA:2.30.30.2707.1E-37167217No hitNo description
PROSITE profilePS5172675.396172443IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557296.9E-112173444IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.306.6E-73231374IPR016181Acyl-CoA N-acyltransferase
PfamPF018539.2E-84233410IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.00151284342No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:0016573Biological Processhistone acetylation
GO:2000028Biological Processregulation of photoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0043995Molecular Functionhistone acetyltransferase activity (H4-K5 specific)
Sequence ? help Back to Top
Protein Sequence    Length: 449 aa     Download sequence    Send to blast
MGSIDVQSTS AENGSASASA DGRQKSLPTD GMNHTSNDPD GAPPDKPKEL GPTKKRLSSM  60
LPLDVGTRVM CRWRDGKYHP VKVIERRKLQ AIGFSDYEYY VHYTEFNRRL DEWVKLDQLD  120
LDSVETVVDE KVEDKVTGLK MTRHQKRKID ETHVEGHEEL DAASLREHEE FTKVKNIATI  180
ELGRYEIETW YFSPFPPEYN DTTKLYFCEF CLNFMKRKEQ LQRHMRKCDL KHPPGDEIYR  240
CGTLSMFEVD GKKNKVYGQN LCYLAKLFLD HKTLYYDVDL FLFYVLCECD DRGCHMVGYF  300
SKEKHSEESY NLACILTLPP YQRKGYGKFL IAFSYELSKK EGKVGTPERP LSDLGLVSYR  360
GYWTRVLLDI LKKHKANISI KELSDMTAIK AEDILNTLQS LELIQYRKGQ HVICADPKVL  420
DRHLKAAGRG GLEVDVSKLI WTPYREQG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1161684431278Histone acetyltransferase KAT8
4dnc_B1e-1161684431278Histone acetyltransferase KAT8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004140319.10.0PREDICTED: probable MYST-like histone acetyltransferase 1
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA0A0A0KRK80.0A0A0A0KRK8_CUCSA; Histone acetyltransferase
STRINGXP_004170573.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF70661011
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  3. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  4. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  5. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  6. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  7. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  8. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  9. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]