PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.159820.1
Common NameCsa_2G367240, LOC101211469
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 307aa    MW: 35438.9 Da    PI: 7.5007
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.159820.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.95.5e-2650115171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+ lt+kf++l++++e+g+++ln+ a+ L   +v  ++RRiYDi+NVLe+++liek+  n+irwkg
  Cucsa.159820.1  50 RYDSSLGFLTKKFIRLVQEAEDGTLDLNKTADVL---KV--QKRRIYDITNVLEGIGLIEKTTTNHIRWKG 115
                     6899******************************...88..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.5E-2746116IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.85E-1750113IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.6E-3350115IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-2452115IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146605.38E-36126230No hitNo description
SuperFamilySSF1440746.8E-27127230No hitNo description
PfamPF164212.0E-25131230IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 307 aa     Download sequence    Send to blast
MRSNDSSCEP VSSANEKQNK KFKLQKNSKS KTRKSIDEPV DSPNQSTNGR YDSSLGFLTK  60
KFIRLVQEAE DGTLDLNKTA DVLKVQKRRI YDITNVLEGI GLIEKTTTNH IRWKGGERRG  120
PQELNDQVGR LKDEVKSLYA DERRLDELIR MKQELLRNLE QNAHYRNHLF ITEEDILRIP  180
CFKNQTLIAV KAPQASCIEV PDPDEEACFS ERQCRMIIKS TTGPIDLYLL RTAKQELEEN  240
TSKQAKLCLA QQKNPNIFTN NTYSPFQDLH GMQRILPLHN NIDDDYWFQS NSQVSITHLW  300
GEEHNF*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-2346115373PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
18288LKVQKRR
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818235e-60LN681823.1 Cucumis melo genomic scaffold, anchoredscaffold00014.
GenBankLN7132575e-60LN713257.1 Cucumis melo genomic chromosome, chr_3.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004152759.10.0PREDICTED: transcription factor E2FC isoform X1
SwissprotQ9FV701e-86E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A0A0LL680.0A0A0A0LL68_CUCSA; Uncharacterized protein
STRINGXP_004152759.10.0(Cucumis sativus)
STRINGXP_004167900.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF118852529
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.21e-88E2F/DP family protein
Publications ? help Back to Top
  1. Ren Y, et al.
    An integrated genetic and cytogenetic map of the cucumber genome.
    PLoS ONE, 2009. 4(6): p. e5795
    [PMID:19495411]
  2. Guo S, et al.
    Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types.
    BMC Genomics, 2010. 11: p. 384
    [PMID:20565788]
  3. Li Z, et al.
    RNA-Seq improves annotation of protein-coding genes in the cucumber genome.
    BMC Genomics, 2011. 12: p. 540
    [PMID:22047402]
  4. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  5. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  6. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]