PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Dca21693.1

Organism

Dianthus caryophyllus

Taxonomic ID

3570

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Caryophyllaceae; Caryophylleae; Dianthus

Family

E2F/DP

Protein Properties

Length: 785aa MW: 87039.7 Da PI: 4.5335

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Dca21693.1	genome	DCA	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	69.9	2.9e-22	132	196	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r++ sL++lt+kf++l++++e+gi++ln+ ++ L v ++RRiYD++NVLe+++liek kn i+wkg Dca21693.1 132 RSDCSLVQLTKKFINLIRRAEDGILDLNKTTEVL---GV--QKRRIYDVTNVLEGIGLIEK-LKNGIQWKG 196 5788****************************.....******************.*****98 PP
2	E2F_TDP	69.9	2.9e-22	464	528	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r++ sL++lt+kf++l++++e+gi++ln+ ++ L v ++RRiYD++NVLe+++liek kn i+wkg Dca21693.1 464 RSDCSLVQLTKKFINLIRRAEDGILDLNKTTEVL---GV--QKRRIYDVTNVLEGIGLIEK-LKNGIQWKG 528 5788****************************.....******************.*****98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.6E-23	130	198	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.3E-30	132	196	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	5.7E-20	134	196	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.7E-16	135	197	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14660	1.03E-45	209	313	No hit	No description
SuperFamily	SSF144074	4.97E-33	210	313	No hit	No description
Pfam	PF16421	4.4E-33	212	311	IPR032198	E2F transcription factor, CC-MB domain
Gene3D	G3DSA:1.10.10.10	1.6E-23	462	530	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.3E-30	464	528	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	5.7E-20	466	528	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.7E-16	467	529	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14660	1.03E-45	541	645	No hit	No description
SuperFamily	SSF144074	4.97E-33	542	645	No hit	No description
Pfam	PF16421	4.4E-33	544	643	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 785 aa Download sequence Send to blast
MSSAPNSTTH LHHSPPTVKR QLHFSLKPPL PGDYHVFSDH PLPPLPEALL LKTPPRKRKN 60 DKAENDAEST VWTSSPGYTE VVNSPIQTPV SEKVSKGQRA PRITKNNKVA PQTPTSNIGS 120 TGNDLTPVGT SRSDCSLVQL TKKFINLIRR AEDGILDLNK TTEVLGVQKR RIYDVTNVLE 180 GIGLIEKLKN GIQWKGFDAS KPGDVDPTVV NLQADVEKLS MEERRLDEHI RNMQERLREV 240 SEDDSNQKWL FVTEEDIKAV PCFQNETLIA VKAPHGTTLE VPDPDEAVDS RQRRYRIVLR 300 STMGPIDVYL VSQFEEKFEE INAGEAASSE PSTSGYNEHP ASDEPNNVNQ DNAAEVEEQA 360 TPAICADAYV AQECSSGIMK IVPEVDPRKR KNDKAENDAE STVWTSSPGY TEVVNSPIQT 420 PVSEKVSKGQ RAPRITKNNK VAPQTPTSNI GSTGNDLTPV GTSRSDCSLV QLTKKFINLI 480 RRAEDGILDL NKTTEVLGVQ KRRIYDVTNV LEGIGLIEKL KNGIQWKGFD ASKPGDVDPT 540 VVNLQADVEK LSMEERRLDE HIRNMQERLR EVSEDDSNQK WLFVTEEDIK AVPCFQNETL 600 IAVKAPHGTT LEVPDPDEAV DSRQRRYRIV LRSTMGPIDV YLVSQFEEKF EEINAGEAAS 660 SEPSTSGYNE HPASDEPNNV NQDNAAEVEE QATPAICADA YVAQECSSGI MKIVPEVDSD 720 ADYWLLSDAD VSISEMWGND SAVDWNELHT VQEEDYVMVN VNAPQSKSPQ PTSTEEAPTN 780 NSTMN

Sequence ? help Back to Top

Protein Sequence Length: 785 aa Download sequence Send to blast

MSSAPNSTTH LHHSPPTVKR QLHFSLKPPL PGDYHVFSDH PLPPLPEALL LKTPPRKRKN  60
DKAENDAEST VWTSSPGYTE VVNSPIQTPV SEKVSKGQRA PRITKNNKVA PQTPTSNIGS  120
TGNDLTPVGT SRSDCSLVQL TKKFINLIRR AEDGILDLNK TTEVLGVQKR RIYDVTNVLE  180
GIGLIEKLKN GIQWKGFDAS KPGDVDPTVV NLQADVEKLS MEERRLDEHI RNMQERLREV  240
SEDDSNQKWL FVTEEDIKAV PCFQNETLIA VKAPHGTTLE VPDPDEAVDS RQRRYRIVLR  300
STMGPIDVYL VSQFEEKFEE INAGEAASSE PSTSGYNEHP ASDEPNNVNQ DNAAEVEEQA  360
TPAICADAYV AQECSSGIMK IVPEVDPRKR KNDKAENDAE STVWTSSPGY TEVVNSPIQT  420
PVSEKVSKGQ RAPRITKNNK VAPQTPTSNI GSTGNDLTPV GTSRSDCSLV QLTKKFINLI  480
RRAEDGILDL NKTTEVLGVQ KRRIYDVTNV LEGIGLIEKL KNGIQWKGFD ASKPGDVDPT  540
VVNLQADVEK LSMEERRLDE HIRNMQERLR EVSEDDSNQK WLFVTEEDIK AVPCFQNETL  600
IAVKAPHGTT LEVPDPDEAV DSRQRRYRIV LRSTMGPIDV YLVSQFEEKF EEINAGEAAS  660
SEPSTSGYNE HPASDEPNNV NQDNAAEVEE QATPAICADA YVAQECSSGI MKIVPEVDSD  720
ADYWLLSDAD VSISEMWGND SAVDWNELHT VQEEDYVMVN VNAPQSKSPQ PTSTEEAPTN  780
NSTMN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5tuu_B	1e-18	204	645	5	110	Transcription factor E2F4
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010685421.1	0.0	PREDICTED: transcription factor E2FB
Swissprot	Q9FV71	1e-111	E2FB_ARATH; Transcription factor E2FB
TrEMBL	Q9FNS0	1e-179	Q9FNS0_OXYRB; Transcription factor (E2F)
STRING	XP_010685421.1	0.0	(Beta vulgaris)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-114	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]