PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID FANhyb_rscf00001142.1.g00004.1
Organism
Fragaria x ananassa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae; Fragaria
Family C2H2
Protein Properties Length: 1090aa    MW: 119713 Da    PI: 8.6258
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
FANhyb_rscf00001142.1.g00004.1genomekazusaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H215.26.2e-057496123
                                    EEETTTTEEESSHHHHHHHHHHT CS
                         zf-C2H2  1 ykCpdCgksFsrksnLkrHirtH 23
                                    + C+ C+k F r  nL+ H r H
  FANhyb_rscf00001142.1.g00004.1 74 FICEVCNKGFQREQNLQLHRRGH 96
                                    89*******************88 PP
2zf-C2H211.40.001150172123
                                     EEETTTTEEESSHHHHHHHHHHT CS
                         zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                                     +kC++C+k++  +s+ k H + +
  FANhyb_rscf00001142.1.g00004.1 150 WKCEKCSKRYAVQSDWKAHSKIC 172
                                     58*****************9876 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
HamapMF_0145832.518661058IPR005936Peptidase, FtsH
Gene3DG3DSA:3.30.160.601.3E-57396IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576671.12E-77396No hitNo description
PfamPF121715.8E-57496IPR022755Zinc finger, double-stranded RNA binding
SMARTSM003550.00527496IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.997496IPR007087Zinc finger, C2H2
PROSITE patternPS0002807696IPR007087Zinc finger, C2H2
SMARTSM00355160115145IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.601.7E-4138171IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576671.12E-7145170No hitNo description
SMARTSM00355130150170IPR015880Zinc finger, C2H2-like
TIGRFAMsTIGR012414.8E-1855921027IPR005936Peptidase, FtsH
Gene3DG3DSA:3.40.50.3003.9E-60595775IPR027417P-loop containing nucleoside triphosphate hydrolase
SuperFamilySSF525403.08E-67596850IPR027417P-loop containing nucleoside triphosphate hydrolase
CDDcd000091.77E-30602764No hitNo description
SMARTSM003824.0E-27631767IPR003593AAA+ ATPase domain
PfamPF000048.1E-44635764IPR003959ATPase, AAA-type, core
PROSITE patternPS006740735753IPR003960ATPase, AAA-type, conserved site
Gene3DG3DSA:1.10.8.604.0E-22776848No hitNo description
PfamPF014343.6E-778261026IPR000642Peptidase M41
SuperFamilySSF1409905.49E-688461031No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006508Biological Processproteolysis
GO:0010073Biological Processmeristem maintenance
GO:0005739Cellular Componentmitochondrion
GO:0009536Cellular Componentplastid
GO:0016020Cellular Componentmembrane
GO:0003676Molecular Functionnucleic acid binding
GO:0004222Molecular Functionmetalloendopeptidase activity
GO:0005524Molecular FunctionATP binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 1090 aa     Download sequence    Send to blast
MMKGFAVDEN MSNLTCASGD LSASANSSIR NDSSSSTHQQ QPAQKKKRNL PGNPDPDAEV  60
IALSPKSLMA TNRFICEVCN KGFQREQNLQ LHRRGHNLPW KLKQRTNKEV KKKVYLCPEP  120
TCVHHDPSRA LGDLTGIKKH FSRKHGEKKW KCEKCSKRYA VQSDWKAHSK ICGTREYRCD  180
CGTLFSRAFS SQDDQDFFDM AAAHGLDQHV VNPTSSANYN GQQHNNQNQT SWPGKYVKIE  240
VEHVNHASKL VTGGKSGTDK DSCKYSNTGA WMSTLLDDGG AGIHAYIGVS MYWWQAGFSV  300
NIQSRREKKT FNTLVSLFSS PFFPNLAPSA SLLPQIETPP FFTHPKFSDT ARFCGMYRGI  360
HRLELSVELS YCTVCRCFEL IERLNLYAEW EGTYDIGGEV MGCVCFSYLS YPFNSTQFVS  420
RHRSELGQLK KVFARTYFPV NRVAGGAGGN TVFNTQERFQ SSYVRSFARR ARELDEVNEL  480
AYLKELSMRN DPEEVIRLFE STPSLHSNSS ALSEYVKSLV KVGRLDESEL LKTLQRGVSN  540
SAREDESVGS FSVLRNVGKS TKDGVLGTAS APIHMVAREG GLGLNEEVQP SMESSTKFTD  600
VKGVDEAKAE LEEIVHYLRD PKRFTRLGGK LPKGVLLVGP PGTGKTMLAR AIAGEAGVPF  660
FSCSGSEFEE MFVGVGARRV RDLFAAAKKR SPCIIFIDEI DAIGGSRNPK DQQYMKMTLN  720
QLLVELDGFK QNEGIIVIAA TNFPESLDKA LVRPGRFDRH IVVPNPDVEG RRQIMEVHMS  780
KVLKADDVDL MIIARGTPGF SGADLANLIN VAALKAAMDG AKAVNMADLE YAKDKIMMGS  840
ERKSAVISDE SRKLTAFHEG GHALVAIHTD GAHPVHKATI VPRGMALGMV AQLPEKDETS  900
VSRKQMLARL DVCMGGRVAE ELIFGESEVT SGASDDLRQA TSLARAMVTK YGMSKEVGLV  960
THNYDDNGKS MSTETRLLIE EEVRRLLETA YNNAKNILTT HHKELHALAN ALLEKETLTG  1020
KQIKALLANL NSQQNQQPQQ QVIAEKSSSQ SNPVPPPSTP NAAQSAAAAA AAAAAAATAA  1080
AKSKGMAPAS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
6az0_A1e-17659710241426Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
6az0_B1e-17659710241426Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
6az0_C1e-17659710241426Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
6az0_D1e-17659710241426Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
6az0_E1e-17659710241426Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
6az0_F1e-17659710241426Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtProbable ATP-dependent zinc metallopeptidase. Involved in the assembly and/or stability of the complex V of the mitochondrial oxidative phosphorylation system. {ECO:0000269|Ref.9}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By high light. {ECO:0000269|PubMed:15266057}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004291047.10.0PREDICTED: ATP-dependent zinc metalloprotease FTSH 4, mitochondrial
SwissprotO809830.0FTSH4_ARATH; ATP-dependent zinc metalloprotease FTSH 4, mitochondrial
TrEMBLA0A2P6Q1E00.0A0A2P6Q1E0_ROSCH; Putative ATPase, AAA-type, core, peptidase, FtsH
STRINGXP_004291047.10.0(Fragaria vesca)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G02080.16e-91indeterminate(ID)-domain 4
Publications ? help Back to Top
  1. Adam Z, et al.
    Chloroplast and mitochondrial proteases in Arabidopsis. A proposed nomenclature.
    Plant Physiol., 2001. 125(4): p. 1912-8
    [PMID:11299370]
  2. Sokolenko A, et al.
    The gene complement for proteolysis in the cyanobacterium Synechocystis sp. PCC 6803 and Arabidopsis thaliana chloroplasts.
    Curr. Genet., 2002. 41(5): p. 291-310
    [PMID:12185496]
  3. Sakamoto W,Zaltsman A,Adam Z,Takahashi Y
    Coordinated regulation and complex formation of yellow variegated1 and yellow variegated2, chloroplastic FtsH metalloproteases involved in the repair cycle of photosystem II in Arabidopsis thylakoid membranes.
    Plant Cell, 2003. 15(12): p. 2843-55
    [PMID:14630971]
  4. Yu F,Park S,Rodermel SR
    The Arabidopsis FtsH metalloprotease gene family: interchangeability of subunits in chloroplast oligomeric complexes.
    Plant J., 2004. 37(6): p. 864-76
    [PMID:14996218]
  5. Sinvany-Villalobo G, et al.
    Expression in multigene families. Analysis of chloroplast and mitochondrial proteases.
    Plant Physiol., 2004. 135(3): p. 1336-45
    [PMID:15266057]
  6. Urantowka A,Knorpp C,Olczak T,Kolodziejczak M,Janska H
    Plant mitochondria contain at least two i-AAA-like complexes.
    Plant Mol. Biol., 2005. 59(2): p. 239-52
    [PMID:16247555]
  7. García-Lorenzo M,Sjödin A,Jansson S,Funk C
    Protease gene families in Populus and Arabidopsis.
    BMC Plant Biol., 2006. 6: p. 30
    [PMID:17181860]
  8. Hazzouri KM,Mohajer A,Dejak SI,Otto SP,Wright SI
    Contrasting patterns of transposable-element insertion polymorphism and nucleotide diversity in autotetraploid and allotetraploid Arabidopsis species.
    Genetics, 2008. 179(1): p. 581-92
    [PMID:18493073]
  9. Ross-Ibarra J, et al.
    Patterns of polymorphism and demographic history in natural populations of Arabidopsis lyrata.
    PLoS ONE, 2008. 3(6): p. e2411
    [PMID:18545707]
  10. Gibala M, et al.
    The lack of mitochondrial AtFtsH4 protease alters Arabidopsis leaf morphology at the late stage of rosette development under short-day photoperiod.
    Plant J., 2009. 59(5): p. 685-99
    [PMID:19453455]
  11. Kicia M,Gola EM,Janska H
    Mitochondrial protease AtFtsH4 protects ageing Arabidopsis rosettes against oxidative damage under short-day photoperiod.
    Plant Signal Behav, 2010. 5(2): p. 126-8
    [PMID:20009533]
  12. Janska H,Piechota J,Kwasniak M
    ATP-dependent proteases in biogenesis and maintenance of plant mitochondria.
    Biochim. Biophys. Acta, 2010 Jun-Jul. 1797(6-7): p. 1071-5
    [PMID:20193658]
  13. Wagner R,Aigner H,Funk C
    FtsH proteases located in the plant chloroplast.
    Physiol Plant, 2012. 145(1): p. 203-14
    [PMID:22121866]
  14. Kmiec B,Urantowka A,Lech M,Janska H
    Two-step processing of AtFtsH4 precursor by mitochondrial processing peptidase in Arabidopsis thaliana.
    Mol Plant, 2012. 5(6): p. 1417-9
    [PMID:22986791]
  15. Zhang S, et al.
    Perturbation of auxin homeostasis caused by mitochondrial FtSH4 gene-mediated peroxidase accumulation regulates arabidopsis architecture.
    Mol Plant, 2014. 7(5): p. 856-73
    [PMID:24482432]
  16. Zhang S,ZHang D,Yang C
    AtFtsH4 perturbs the mitochondrial respiratory chain complexes and auxin homeostasis in Arabidopsis.
    Plant Signal Behav, 2015.
    [PMID:25061946]
  17. Carrie C,Venne AS,Zahedi RP,Soll J
    Identification of cleavage sites and substrate proteins for two mitochondrial intermediate peptidases in Arabidopsis thaliana.
    J. Exp. Bot., 2015. 66(9): p. 2691-708
    [PMID:25732537]
  18. Zhang S,Zhang D,Yang C
    AtFtsH4 perturbs the mitochondrial respiratory chain complexes and auxin homeostasis in Arabidopsis.
    Plant Signal Behav, 2014. 9(9): p. e29709
    [PMID:25763704]
  19. Smakowska E, et al.
    Lack of FTSH4 Protease Affects Protein Carbonylation, Mitochondrial Morphology, and Phospholipid Content in Mitochondria of Arabidopsis: New Insights into a Complex Interplay.
    Plant Physiol., 2016. 171(4): p. 2516-35
    [PMID:27297677]
  20. Dolzblasz A, et al.
    The mitochondrial protease AtFTSH4 safeguards Arabidopsis shoot apical meristem function.
    Sci Rep, 2016. 6: p. 28315
    [PMID:27321362]
  21. Hong L, et al.
    Variable Cell Growth Yields Reproducible OrganDevelopment through Spatiotemporal Averaging.
    Dev. Cell, 2016. 38(1): p. 15-32
    [PMID:27404356]
  22. Zhang S, et al.
    The Arabidopsis Mitochondrial Protease FtSH4 Is Involved in Leaf Senescence via Regulation of WRKY-Dependent Salicylic Acid Accumulation and Signaling.
    Plant Physiol., 2017. 173(4): p. 2294-2307
    [PMID:28250067]
  23. Opalińska M,Parys K,Jańska H
    Identification of Physiological Substrates and Binding Partners of the Plant Mitochondrial Protease FTSH4 by the Trapping Approach.
    Int J Mol Sci, 2018.
    [PMID:29156584]
  24. Dolzblasz A, et al.
    Impairment of Meristem Proliferation in Plants Lacking the Mitochondrial Protease AtFTSH4.
    Int J Mol Sci, 2018.
    [PMID:29538317]