PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

FANhyb_rscf00002720.1.g00001.1

Organism

Fragaria x ananassa

Taxonomic ID

3747

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae; Fragaria

Family

C2H2

Protein Properties

Length: 482aa MW: 55359.1 Da PI: 8.1924

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
FANhyb_rscf00002720.1.g00001.1	genome	kazusa	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	11.8	0.00075	139	161	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 y C+ C +rk++L+rH+r++ FANhyb_rscf00002720.1.g00001.1 139 YFCEFCLNFMKRKEQLQRHMRKC 161 78*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54160	4.12E-8	36	106	IPR016197	Chromo domain-like
PROSITE profile	PS51726	53.674	105	325	IPR002717	Histone acetyltransferase domain, MYST-type
SuperFamily	SSF55729	5.07E-73	108	308	IPR016181	Acyl-CoA N-acyltransferase
Gene3D	G3DSA:3.30.60.60	2.0E-25	110	162	No hit	No description
Gene3D	G3DSA:3.40.630.30	3.2E-31	182	253	IPR016181	Acyl-CoA N-acyltransferase
Pfam	PF01853	5.6E-43	182	289	IPR002717	Histone acetyltransferase domain, MYST-type

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006281	Biological Process	DNA repair
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010224	Biological Process	response to UV-B
GO:2000028	Biological Process	regulation of photoperiodism, flowering
GO:0005634	Cellular Component	nucleus
GO:0043995	Molecular Function	histone acetyltransferase activity (H4-K5 specific)

Sequence ? help Back to Top
Protein Sequence Length: 482 aa Download sequence Send to blast
MDVEAKIKGT FVRLWQDSPV LQSGFGGFLG IEKKYYARVN RRLDEWVKLD QLDLDSVEAV 60 VDEKVEDKVT SLKMTRHQKR KIDETHVEGH EELDAASLRE HEEFTKVKNI ATIELGRYEI 120 ETWYFSPFPP EYNDSGKLYF CEFCLNFMKR KEQLQRHMRK CDLKHPPGDE IYRNHTLSMF 180 EEKHSEESYN LACILTLPPY QRKGYGKFLI AFSYELSKKE GKVGTPERPL SDLGLLSYRG 240 YWTRVLLDIL KKHKGNISIK ELSDMTAIKA EDILTTLQSL ELIQYRKGQH VICADPKVLD 300 RHLKAAGPAG LELVAVAAVA VAVVVLVGVA RGVRFFAGEE FLELGILDIV AAVGILSGDR 360 IARNFVAPLN LAHTTDSWRY RMSVYMMMVV VVVVLVVMVK AVILISHSST TLLLNYSIFG 420 QQLKRFTRMS SRNGKFFEPP SAQNIEVFIQ LGQKEMQIMY LDELLRERGR GGEERRGERE 480 YY

Sequence ? help Back to Top

Protein Sequence Length: 482 aa Download sequence Send to blast

MDVEAKIKGT FVRLWQDSPV LQSGFGGFLG IEKKYYARVN RRLDEWVKLD QLDLDSVEAV  60
VDEKVEDKVT SLKMTRHQKR KIDETHVEGH EELDAASLRE HEEFTKVKNI ATIELGRYEI  120
ETWYFSPFPP EYNDSGKLYF CEFCLNFMKR KEQLQRHMRK CDLKHPPGDE IYRNHTLSMF  180
EEKHSEESYN LACILTLPPY QRKGYGKFLI AFSYELSKKE GKVGTPERPL SDLGLLSYRG  240
YWTRVLLDIL KKHKGNISIK ELSDMTAIKA EDILTTLQSL ELIQYRKGQH VICADPKVLD  300
RHLKAAGPAG LELVAVAAVA VAVVVLVGVA RGVRFFAGEE FLELGILDIV AAVGILSGDR  360
IARNFVAPLN LAHTTDSWRY RMSVYMMMVV VVVVLVVMVK AVILISHSST TLLLNYSIFG  420
QQLKRFTRMS SRNGKFFEPP SAQNIEVFIQ LGQKEMQIMY LDELLRERGR GGEERRGERE  480
YY

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4dnc_A	9e-75	101	306	1	260	Histone acetyltransferase KAT8
4dnc_B	9e-75	101	306	1	260	Histone acetyltransferase KAT8
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Functional Description ? help Back to Top
Source	Description
UniProt	Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269\|PubMed:17877703, ECO:0000269\|PubMed:19040736, ECO:0000269\|PubMed:22170978, ECO:0000269\|PubMed:23273925}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269\|PubMed:22170978}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_022768251.1	0.0	histone acetyltransferase of the MYST family 1 isoform X3
Swissprot	Q9FLF7	1e-177	MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBL	A0A251RFU1	0.0	A0A251RFU1_PRUPE; Histone acetyltransferase
STRING	XP_004300418.1	0.0	(Fragaria vesca)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF7066	10	11

Publications ? help Back to Top
Latrasse D, et al. The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis. BMC Plant Biol., 2008. 8: p. 121 [PMID:19040736] Campi M,D'Andrea L,Emiliani J,Casati P Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA. Plant Physiol., 2012. 158(2): p. 981-95 [PMID:22170978] Bari A,Orazova S,Ivashchenko A miR156- and miR171-binding sites in the protein-coding sequences of several plant genes. Biomed Res Int, 2013. 2013: p. 307145 [PMID:23936788] Xu Y, et al. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res., 2014. 42(17): p. 10960-74 [PMID:25183522] Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB 3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana. J Mol Model, 2016. 22(11): p. 256 [PMID:27709438] Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis. Front Plant Sci, 2017. 8: p. 1179 [PMID:28740501]