PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID GRMZM2G060000_P01
Common NameE2F12, LOC103629955, Zm.26889
Organism
Zea mays
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea
Family E2F/DP
Protein Properties Length: 425aa    MW: 47026.9 Da    PI: 8.7166
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
GRMZM2G060000_P01genomeMaizeSequenceView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.35.4e-2355120171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                        rk+ksL+ll+++f++l+ +++ +++ l+++ak+L    v  +rRRiYDi+NVLe+++++ +++kn+++w g
  GRMZM2G060000_P01  55 RKQKSLGLLCSNFVALYDREDVEVIGLDDAAKRL---GV--ERRRIYDIVNVLESVGILVRRAKNRYTWLG 120
                        79****************9999************...**..****************************87 PP
2E2F_TDP80.21.9e-25200280171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                        rkeksL+lltq+f+kl+ + e g+++l+e+a+ L+ e     ++++k+RR+YDi+NVL++lnliek     ++k+++rw g
  GRMZM2G060000_P01 200 RKEKSLGLLTQNFVKLFLNMEVGTISLDEAARLLLGEghadsNMRTKVRRLYDIANVLSSLNLIEKtqqadTRKPAFRWLG 280
                        79******************************************************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.5E-2651121IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.14E-1654119IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.8E-2855120IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-2056120IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.5E-23197281IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-33200280IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.3E-21201280IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.68E-13202280IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 425 aa     Download sequence    Send to blast
MDASAATPAP GPSFSGAESS AAAAQPPAEA PQLRVHGAGS GSGVARACRH HAYSRKQKSL  60
GLLCSNFVAL YDREDVEVIG LDDAAKRLGV ERRRIYDIVN VLESVGILVR RAKNRYTWLG  120
FGGVPAALKE LKERALRKMS GSPVLLSMED SSTANLSDDE DDEKLGDADE DAESEKLSQP  180
VDNTSDKPDA PSCRLRSDHR KEKSLGLLTQ NFVKLFLNME VGTISLDEAA RLLLGEGHAD  240
SNMRTKVRRL YDIANVLSSL NLIEKTQQAD TRKPAFRWLG QAKRKQDNNV MVSVPPSMKA  300
MPNKRAFGTD LTNIDNKRGK LDSAAENKVK LMQGAGNIVK TFERQLVQGK RSDFVYGPFH  360
PAGAKKHETD DQTVKQQERK NIQDWENLAV SFRPQYQNQA LNDLFGHYVE AWKSWYVDLT  420
QETAS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A5e-36542723228Transcription factor E2F8
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Zm.268890.0aerial organ| cell culture| cell lignification| meristem
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasGRMZM2G060000
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapGRMZM2G060000_P01
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKJ7280270.0KJ728027.1 Zea mays clone pUT6165 E2F-DP transcription factor (E2F12) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008649275.10.0E2F transcription factor-like E2FE
RefseqXP_008649276.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-105E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLK7UGV90.0K7UGV9_MAIZE; E2F transcription factor-like E2FE (Fragment)
STRINGGRMZM2G060000_P020.0(Zea mays)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-106DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]