PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Gh_A07G1021

Organism

Gossypium hirsutum

Taxonomic ID

3635

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

E2F/DP

Protein Properties

Length: 505aa MW: 55910.5 Da PI: 4.6642

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Gh_A07G1021	genome	NAU-NBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	81	1e-25	145	211	1	71
E2F_TDP 1 rkeksL.rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL rllt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Gh_A07G1021 145 RYDSSLgRLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 211 5678884579***********************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.9E-27	143	213	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.1E-31	145	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	9.5E-23	147	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	4.22E-15	152	209	IPR011991	Winged helix-turn-helix DNA-binding domain
CDD	cd14660	6.35E-49	222	328	No hit	No description
SuperFamily	SSF144074	1.05E-33	224	328	No hit	No description
Pfam	PF16421	1.1E-33	227	326	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 505 aa Download sequence Send to blast
MSDSQTPEQL KQPMQQQQQQ NWQPLKRQLP FSTKPPFMAS GGDYHRFAST EPRRVADHEA 60 EAIVVKSPLK RKSDLADREV ESSEWALPPG CTELGSSPLQ TPVSGKGGKA QKTSRLTKNS 120 KSGPQTPASN LGSPGNNLTP AGPCRYDSSL GRLLTKKFIN LIKQAEDGIL DLNKAADTLE 180 VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRPGEV DDNVATLQAE VENLSIEERR 240 LDEKIREMQE RLRDLSEDEN NQKWLFVTED DIKSLPCFQN ETLIAIKAPH GTTLEVPDPD 300 EAVDYSQRRY RIVLRSSMGP IDVYLVSQFE EKFEEIQGGD PPPNFPSTSG LNENSATAMV 360 TEESSGKEIE MQGHDANRMC SDLSASQDFV SGIMKIVPSE VDSDADYWLL SDPGVSITDM 420 WRTEPGVDWN EFDTLHEDFG MATVSAPGPQ TPPPSNATEV PSNSTGRLAT RCFLGSSEEL 480 KNRKLVAQSM YTTTGVRATV GGNLI

Sequence ? help Back to Top

Protein Sequence Length: 505 aa Download sequence Send to blast

MSDSQTPEQL KQPMQQQQQQ NWQPLKRQLP FSTKPPFMAS GGDYHRFAST EPRRVADHEA  60
EAIVVKSPLK RKSDLADREV ESSEWALPPG CTELGSSPLQ TPVSGKGGKA QKTSRLTKNS  120
KSGPQTPASN LGSPGNNLTP AGPCRYDSSL GRLLTKKFIN LIKQAEDGIL DLNKAADTLE  180
VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRPGEV DDNVATLQAE VENLSIEERR  240
LDEKIREMQE RLRDLSEDEN NQKWLFVTED DIKSLPCFQN ETLIAIKAPH GTTLEVPDPD  300
EAVDYSQRRY RIVLRSSMGP IDVYLVSQFE EKFEEIQGGD PPPNFPSTSG LNENSATAMV  360
TEESSGKEIE MQGHDANRMC SDLSASQDFV SGIMKIVPSE VDSDADYWLL SDPGVSITDM  420
WRTEPGVDWN EFDTLHEDFG MATVSAPGPQ TPPPSNATEV PSNSTGRLAT RCFLGSSEEL  480
KNRKLVAQSM YTTTGVRATV GGNLI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-25	140	212	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Ghi.22630	0.0	boll

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:16514015}.
Uniprot	TISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269\|PubMed:16514015}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016743891.1	0.0	PREDICTED: transcription factor E2FB-like
Swissprot	Q9FV71	1e-173	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A1U8NY59	0.0	A0A1U8NY59_GOSHI; transcription factor E2FB-like
STRING	Gorai.001G123900.1	0.0	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM808	28	121

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-175	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]