PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_D01G0879
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family bHLH
Protein Properties Length: 73aa    MW: 8734.33 Da    PI: 10.3238
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_D01G0879genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH29.11.7e-0925661055
                 HHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
          HLH 10 rrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55
                 + RR++i +++  L++l+P +    +k  +Ka +L + ++Y++sLq
  Gh_D01G0879 25 KVRREKISERMKYLQDLVPGC----NKITDKAGMLNEIINYVQSLQ 66
                 78*******************....999*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF000251.8E-5226IPR006689Small GTPase superfamily, ARF/SAR type
PROSITE profilePS5088813.1861565IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474594.32E-141671IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.105.6E-141671IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.5E-52171IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.33E-72470No hitNo description
PfamPF000105.1E-72566IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0005525Molecular FunctionGTP binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 73 aa     Download sequence    Send to blast
MIKFKAFDLG CHQIARRVWK DYYAKVRREK ISERMKYLQD LVPGCNKITD KAGMLNEIIN  60
YVQSLQRQVE VKK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.116805e-70boll
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1098755935e-70
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed constitutively in roots, leaves, and stems. {ECO:0000269|PubMed:12679534}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC2431465e-60AC243146.1 Gossypium hirsutum clone MX073K14-jni, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012491366.12e-48PREDICTED: GTP-binding protein SAR1-like isoform X2
RefseqXP_012491372.12e-48PREDICTED: GTP-binding protein SAR1-like isoform X2
RefseqXP_012491379.12e-48PREDICTED: GTP-binding protein SAR1-like isoform X2
SwissprotQ8GY611e-22BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A0D2Q1385e-47A0A0D2Q138_GOSRA; Uncharacterized protein (Fragment)
TrEMBLA0A2P5S3886e-47A0A2P5S388_GOSBA; Uncharacterized protein
STRINGGorai.001G193500.19e-48(Gossypium raimondii)
STRINGGorai.001G223600.11e-47(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM16325314
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G34530.16e-25cryptochrome-interacting basic-helix-loop-helix 1
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]