PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_D07G1097
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 469aa    MW: 52139.2 Da    PI: 4.6105
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_D07G1097genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.29e-26145211171
      E2F_TDP   1 rkeksL.rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL rllt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Gh_D07G1097 145 RYDSSLgRLLTKKFINLIKQAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 211
                  5678884579*************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.5E-27143213IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.1E-31145211IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.6E-23147211IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.81E-15152209IPR011991Winged helix-turn-helix DNA-binding domain
CDDcd146601.00E-48222328No hitNo description
SuperFamilySSF1440749.15E-34224328No hitNo description
PfamPF164219.7E-34227326IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 469 aa     Download sequence    Send to blast
MSDSQTPEQL KQPMQQQQQQ NRQPLKRQLP FSTKPPFMAS GGDYHRFAST EPRRVADHEA  60
EAIVVKSPLK RKSDVADREV ESSEWALPPG CTELVSSPLQ TPVSGKGGKA QKTSRLTKNS  120
KSGPQTPASN LGSPGNNLTP AGPCRYDSSL GRLLTKKFIN LIKQAEDGIL DLNKAADTLE  180
VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GLDVSRPGEV DDNVATLQAE VENLSIEERR  240
LDEKIREMQE RLRDLSEDEN NQKWLFVTED DIKSLPCFQN ETLIAIKAPH GTTLEVPDPD  300
EAVDYSQRRY RIVLRSSMGP IDVYLVSQFE EKFEEIQGGD PPPNFPSTSG LNENSAMAMV  360
TEESRGKEIE MQGHDANRMC SDLSASQDFV SGIMKIVPSE VDSDADYWLL SDPGVSITDM  420
WRTEPGVDWN EFDTLHEDFG MATVSASGPQ TPPPSNATEV PSNSTGRLP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-25140212274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.226300.0boll
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:16514015}.
UniprotTISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269|PubMed:16514015}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016745083.10.0PREDICTED: transcription factor E2FB-like
SwissprotQ9FV711e-171E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A1U8P4070.0A0A1U8P407_GOSHI; transcription factor E2FB-like
STRINGGorai.001G123900.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-173E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]