PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_D08G1034
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 385aa    MW: 43328.8 Da    PI: 9.7993
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_D08G1034genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.62e-232186171
      E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                 rk+ksL+ll+++fl++++k   + + l+e+a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Gh_D08G1034 21 RKQKSLGLLCSNFLSMYNKDGIEFIGLDEAAARL---GV--ERRRIYDIVNVLESVGVLTRKAKNKYTWKG 86
                 79*****************999************...**..****************************98 PP
2E2F_TDP77.31.5e-24158238171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                  r+eksL+lltq+f+kl+ +s+++ ++l+e+a+ L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Gh_D08G1034 158 RREKSLGLLTQNFVKLFLCSSAELISLDEAARLLLGNahntsVMRTKVRRLYDIANVLSSMNLIEKthtvdTRKPAFRWLG 238
                  689*******************************9999*99999***********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.7E-261787IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.95E-162084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.5E-272186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.8E-202286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.2E-23156239IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.5E-32158238IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-19160238IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.43E-14160239IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MPVSSSSSLP ESSSRHYTYS RKQKSLGLLC SNFLSMYNKD GIEFIGLDEA AARLGVERRR  60
IYDIVNVLES VGVLTRKAKN KYTWKGFGAI PKALQNLKEE GFSSNLKKFD LHIIAKVSDD  120
DDEDEEDEGF FNPITGSQTE TSKSTSILKS SSVKVDNRRE KSLGLLTQNF VKLFLCSSAE  180
LISLDEAARL LLGNAHNTSV MRTKVRRLYD IANVLSSMNL IEKTHTVDTR KPAFRWLGLR  240
GKSEKGSADA LVLNESKKRV FGTDVTNVSF KKNKVDSSND QNFNKSQQKH KKVENLAPAD  300
DISRSEDSKQ ASKSYQFGPF APVNLTKISN SENDAKPVHD WESLASTYRP QYHNQALRDL  360
FSHYMEAWKS WYSEVAGKTP IKQIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-41202303228Transcription factor E2F8
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ghi.211290.0boll
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016692668.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-138E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1U8JV740.0A0A1U8JV74_GOSHI; E2F transcription factor-like E2FE
STRINGGorai.004G114000.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-133DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]