PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Gh_Sca101437G01

Organism

Gossypium hirsutum

Taxonomic ID

3635

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium

Family

bHLH

Protein Properties

Length: 73aa MW: 8245.26 Da PI: 10.1549

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Gh_Sca101437G01	genome	NAU-NBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	20	1.2e-06	51	72	4	25
HHHHHHHHHHHHHHHHHHHHHC CS HLH 4 ahnerErrRRdriNsafeeLre 25 +h e+Er+RR+++N++f Lr Gh_Sca101437G01 51 NHVEAERQRREKLNQRFYALRA 72 799***************9996 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	10.086	47	73	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	3.05E-6	47	72	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	5.8E-6	50	72	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 73 aa Download sequence Send to blast
MKSSGGAGDS DNSDIEASVV KEAECVKPLE PEKKPRKRGR KPANGREEPL NHVEAERQRR 60 EKLNQRFYAL RAV

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	32	40	KKPRKRGRK

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Constitutively expressed in roots, stems, leaves, flowers, and seedlings. {ECO:0000269\|PubMed:12136026, ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:21335373}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. With MYC2 and MYC4, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. {ECO:0000269\|PubMed:12136026, ECO:0000269\|PubMed:21242320, ECO:0000269\|PubMed:21321051, ECO:0000269\|PubMed:21335373, ECO:0000269\|PubMed:23943862}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Barely up-regulated by jasmonic acid. {ECO:0000269\|PubMed:21242320, ECO:0000269\|PubMed:21335373}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012439320.1	6e-43	PREDICTED: transcription factor MYC2-like isoform X1
Refseq	XP_012439321.1	5e-43	PREDICTED: transcription factor MYC2-like isoform X2
Refseq	XP_012439322.1	5e-43	PREDICTED: transcription factor MYC2-like isoform X3
Refseq	XP_016736690.1	6e-43	PREDICTED: transcription factor MYC2
Refseq	XP_016736787.1	6e-43	PREDICTED: transcription factor MYC2-like
Refseq	XP_017638177.1	5e-43	PREDICTED: transcription factor MYC2-like
Swissprot	Q9FIP9	2e-31	MYC3_ARATH; Transcription factor MYC3
TrEMBL	A0A0D2T538	1e-41	A0A0D2T538_GOSRA; Uncharacterized protein
TrEMBL	A0A1U8NCF0	1e-41	A0A1U8NCF0_GOSHI; transcription factor MYC2
TrEMBL	A0A1U8NCN1	1e-41	A0A1U8NCN1_GOSHI; transcription factor MYC2-like
TrEMBL	A0A288F8J6	1e-41	A0A288F8J6_GOSHI; MYC transcription factor 3 (Fragment)
STRING	Gorai.008G226300.1	2e-42	(Gossypium raimondii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6611	27	41

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G32640.1	3e-17	bHLH family protein

Publications ? help Back to Top
Chico JM, et al. Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis. Plant Cell, 2014. 26(5): p. 1967-1980 [PMID:24824488] Gasperini D, et al. Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth. PLoS Genet., 2015. 11(6): p. e1005300 [PMID:26070206] Qi T, et al. Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis. Plant Cell, 2015. 27(6): p. 1634-49 [PMID:26071420] de Torres Zabala M, et al. Novel JAZ co-operativity and unexpected JA dynamics underpin Arabidopsis defence responses to Pseudomonas syringae infection. New Phytol., 2016. 209(3): p. 1120-34 [PMID:26428397] Yu J, et al. JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis. J. Exp. Bot., 2016. 67(3): p. 751-62 [PMID:26547795] Chen X,Huang H,Qi T,Liu B,Song S New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis. Plant Signal Behav, 2016. 11(2): p. e1135280 [PMID:26829586] Schmiesing A,Emonet A,Gouhier-Darimont C,Reymond P Arabidopsis MYC Transcription Factors Are the Target of Hormonal Salicylic Acid/Jasmonic Acid Cross Talk in Response to Pieris brassicae Egg Extract. Plant Physiol., 2016. 170(4): p. 2432-43 [PMID:26884488] Thatcher LF, et al. Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum. J. Exp. Bot., 2016. 67(8): p. 2367-86 [PMID:26896849] Gao C, et al. MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis. Plant Physiol. Biochem., 2016. 108: p. 63-70 [PMID:27415132] Gimenez-Ibanez S, et al. JAZ2 controls stomata dynamics during bacterial invasion. New Phytol., 2017. 213(3): p. 1378-1392 [PMID:28005270] Zhang F, et al. Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. Proc. Natl. Acad. Sci. U.S.A., 2017. 114(7): p. 1720-1725 [PMID:28137867] Lian TF,Xu YP,Li LF,Su XD Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep, 2017. 19(7): p. 1334-1342 [PMID:28514654] Wang H, et al. The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis. Mol Plant, 2017. 10(11): p. 1461-1464 [PMID:28827172] Song S, et al. MYC5 is Involved in Jasmonate-Regulated Plant Growth, Leaf Senescence and Defense Responses. Plant Cell Physiol., 2017. 58(10): p. 1752-1763 [PMID:29017003] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884]