PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gorai.004G114000.1
Common NameB456_004G114000, LOC105791108
Organism
Gossypium raimondii
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 386aa    MW: 43307.6 Da    PI: 9.7202
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gorai.004G114000.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.62e-232186171
             E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                        rk+ksL+ll+++fl++++k   + + l+e+a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Gorai.004G114000.1 21 RKQKSLGLLCSNFLSMYNKDGIEFIGLDEAAARL---GV--ERRRIYDIVNVLESVGVLTRKAKNKYTWKG 86
                        79*****************999************...**..****************************98 PP
2E2F_TDP78.56.4e-25158238171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                         r+eksL+lltq+f+kl+ +s+++ ++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Gorai.004G114000.1 158 RREKSLGLLTQNFVKLFLCSSAELISLDEAAKLLLGNahntsVMRTKVRRLYDIANVLSSMNLIEKthtvdTRKPAFRWLG 238
                         689********************************999*99999***********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.107.7E-261787IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.95E-162084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.5E-272186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.8E-202286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.9E-24156239IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-32158238IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.7E-20160238IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.45E-13160239IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MPVSSSSSLP ESSSRHYTYS RKQKSLGLLC SNFLSMYNKD GIEFIGLDEA AARLGVERRR  60
IYDIVNVLES VGVLTRKAKN KYTWKGFGAI PKALQNLKEE GFSSNFNKFD VHNIAKVSDD  120
DDEDEEDEGF FNPITGSQTE TSKSTSILKS SSVKVDNRRE KSLGLLTQNF VKLFLCSSAE  180
LISLDEAAKL LLGNAHNTSV MRTKVRRLYD IANVLSSMNL IEKTHTVDTR KPAFRWLGLR  240
GKSEKGSADA LVLNESKKRV FGTDVTNVSF KKNKVDSSND QNFNKSQQKH KKVENLAPAD  300
DISRSEDSKQ ASKSYQFGPF APVNLTKISN SENDAKPVHD WESLASTYRP QYHNQALRDL  360
FSHYMEAWKS WYSEVAGKTP IKQIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A7e-42202303228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012474472.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-140E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A0D2R2U40.0A0A0D2R2U4_GOSRA; Uncharacterized protein
STRINGGorai.004G114000.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-136DP-E2F-like 1
Publications ? help Back to Top
  1. Paterson AH, et al.
    Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.
    Nature, 2012. 492(7429): p. 423-7
    [PMID:23257886]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]