PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gorai.004G114000.2
Common NameB456_004G114000
Organism
Gossypium raimondii
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family E2F/DP
Protein Properties Length: 342aa    MW: 38285.8 Da    PI: 8.8891
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gorai.004G114000.2genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP55.31.1e-172173158
             E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnl 58
                        rk+ksL+ll+++fl++++k   + + l+e+a +L    v  +rRRiYDi+NVLe++++
  Gorai.004G114000.2 21 RKQKSLGLLCSNFLSMYNKDGIEFIGLDEAAARL---GV--ERRRIYDIVNVLESVGV 73
                        79*****************999************...**..**************986 PP
2E2F_TDP78.85.2e-25114194171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                         r+eksL+lltq+f+kl+ +s+++ ++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Gorai.004G114000.2 114 RREKSLGLLTQNFVKLFLCSSAELISLDEAAKLLLGNahntsVMRTKVRRLYDIANVLSSMNLIEKthtvdTRKPAFRWLG 194
                         689********************************999*99999***********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.9E-191773IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.69E-112073IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.4E-1321106IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.7E-142273IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.6E-24112195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-32114194IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.8E-20116194IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467859.52E-14116195IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 342 aa     Download sequence    Send to blast
MPVSSSSSLP ESSSRHYTYS RKQKSLGLLC SNFLSMYNKD GIEFIGLDEA AARLGVERRR  60
IYDIVNVLES VGVSDDDDED EEDEGFFNPI TGSQTETSKS TSILKSSSVK VDNRREKSLG  120
LLTQNFVKLF LCSSAELISL DEAAKLLLGN AHNTSVMRTK VRRLYDIANV LSSMNLIEKT  180
HTVDTRKPAF RWLGLRGKSE KGSADALVLN ESKKRVFGTD VTNVSFKKNK VDSSNDQNFN  240
KSQQKHKKVE NLAPADDISR SEDSKQASKS YQFGPFAPVN LTKISNSEND AKPVHDWESL  300
ASTYRPQYHN QALRDLFSHY MEAWKSWYSE VAGKTPIKQI S*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-20201863228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012474472.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-116E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A0D2MWV40.0A0A0D2MWV4_GOSRA; Uncharacterized protein
STRINGGorai.004G114000.10.0(Gossypium raimondii)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.13e-88DP-E2F-like protein 3
Publications ? help Back to Top
  1. Paterson AH, et al.
    Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.
    Nature, 2012. 492(7429): p. 423-7
    [PMID:23257886]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]