PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

HL.SW.v1.0.G030792.1

Organism

Humulus lupulus

Taxonomic ID

3486

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus

Family

CAMTA

Protein Properties

Length: 1058aa MW: 119350 Da PI: 5.9635

Description

CAMTA family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
HL.SW.v1.0.G030792.1	genome	HOPBASE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	CG-1	179.8	3.2e-56	20	136	2	118
CG-1 2 lkekkrwlkneeiaaiLenfekheltlelktrpksgsliLynrkkvryfrkDGyswkkkkdgktvrEdhekLKvggvevlycyYahsee 90 ++ ++rwl++ ei++iL+n++k++++ e+++ p++gsl+L++rk++ryfrkDG++w+kkkdgktv+E+he+LK g+++vl+cyYah+ee HL.SW.v1.0.G030792.1 20 IEAQHRWLRPAEICEILQNYKKFRIAPEPANMPPNGSLFLFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKAGSIDVLHCYYAHGEE 108 5679*********************************************************************************** PP CG-1 91 nptfqrrcywlLeeelekivlvhylevk 118 n++fqrr+yw+Lee+l++ivlvhy+evk HL.SW.v1.0.G030792.1 109 NENFQRRSYWMLEEDLSHIVLVHYREVK 136 ***********************986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51437	82.92	15	141	IPR005559	CG-1 DNA-binding domain
SMART	SM01076	1.4E-78	18	136	IPR005559	CG-1 DNA-binding domain
Pfam	PF03859	2.3E-49	21	134	IPR005559	CG-1 DNA-binding domain
Gene3D	G3DSA:2.60.40.10	4.1E-5	470	558	IPR013783	Immunoglobulin-like fold
Pfam	PF01833	5.4E-6	473	557	IPR002909	IPT domain
SuperFamily	SSF81296	2.13E-17	473	558	IPR014756	Immunoglobulin E-set
PROSITE profile	PS50297	17.263	638	777	IPR020683	Ankyrin repeat-containing domain
Gene3D	G3DSA:1.25.40.20	3.0E-17	655	771	IPR020683	Ankyrin repeat-containing domain
SuperFamily	SSF48403	3.58E-16	663	768	IPR020683	Ankyrin repeat-containing domain
CDD	cd00204	1.29E-11	671	765	No hit	No description
Pfam	PF12796	2.1E-6	678	769	IPR020683	Ankyrin repeat-containing domain
SMART	SM00248	0.041	706	735	IPR002110	Ankyrin repeat
PROSITE profile	PS50088	9.084	706	738	IPR002110	Ankyrin repeat
SMART	SM00248	840	745	774	IPR002110	Ankyrin repeat
SuperFamily	SSF52540	1.12E-8	875	930	IPR027417	P-loop containing nucleoside triphosphate hydrolase
SMART	SM00015	0.26	879	901	IPR000048	IQ motif, EF-hand binding site
PROSITE profile	PS50096	8.846	881	909	IPR000048	IQ motif, EF-hand binding site
Pfam	PF00612	0.0074	882	900	IPR000048	IQ motif, EF-hand binding site
SMART	SM00015	1.3E-5	902	924	IPR000048	IQ motif, EF-hand binding site
PROSITE profile	PS50096	9.889	903	927	IPR000048	IQ motif, EF-hand binding site
Pfam	PF00612	5.4E-5	905	924	IPR000048	IQ motif, EF-hand binding site

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009409	Biological Process	response to cold
GO:0010150	Biological Process	leaf senescence
GO:0042742	Biological Process	defense response to bacterium
GO:0050832	Biological Process	defense response to fungus
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0005516	Molecular Function	calmodulin binding

Sequence ? help Back to Top
Protein Sequence Length: 1058 aa Download sequence Send to blast
MADSRRLGLA NQLDIEQILI EAQHRWLRPA EICEILQNYK KFRIAPEPAN MPPNGSLFLF 60 DRKVLRYFRK DGHNWRKKKD GKTVKEAHER LKAGSIDVLH CYYAHGEENE NFQRRSYWML 120 EEDLSHIVLV HYREVKGNRT NYNRIKETEE ADTAPSSEID SPASSSIPPN SYQMLSQTTD 180 TTSLNSAQAS EYEDAESAYN QASSRLHPFL ELQQPFAEKI NAGINDAYYP VSFSNNNQEK 240 LSAIPGMDSS AGVSSDHPKN LDFPAWDNTL GNNAASIHLP FQPAFSATQS NNLTAIQKQE 300 QEPFEQLFTN GFGKHPQIQE EWQASEGNSR LPKWPVDQTL LTGSDNNLTF RYQSEVASGD 360 ELLKVHRGNA EHDDFVKPVS KSNMNLEEKP YISGMKQPLL DGSFAEEGLK KLDSFNRWMS 420 KELGDVNESH MQTTSRAYWN SVESDTCVDD SSQVRLDNYV LSPSLSQEQL FSIIDFSPNW 480 AYESSEVKVL ITGRFLKVDQ AEMNKWSCMF GEVEVPAEII AEGVLRCNAP IHKVGRVPFY 540 VTCSNRLACS EVREFEYRLN EARDVQTKYN QSGCTNEILK LRFGKLMSLT STSSNANPVN 600 LAEMSQLSNK ISSLLKEDQD EWDQMFRLTS EENFSVERVQ EQLHQKLLKE KLHEWLLHKV 660 AEGGKGPSLL DEGGQGVLHF AAALGYDWAL EPTIVAGVSV NFRDANGWTA LHWAAFCGRE 720 RTVASLISLG AAPGLLTDPS PKYPSGKTPA DLASDNGHKG ISGYLAESAL SAHLKCLDLD 780 AKAGKTTDTS ILNAVQTVSE RTATPIKDGD PDRLSLKDSL AAVCNATQAA ARIHQVFRVQ 840 SFQRKQLEEF SDDKFGLSNE QALSLIAVKA QKSGRQNDDV NAAAIRIQNK FRGWKGRKDF 900 LNMRQNVVKI QAHVRGHQVR KNYKKFVWSV GIVEKIILRW RRKGSGLRGF KSEPVVEVPS 960 IQDQSSSKDD DYDFLKEGRK QSEQRMQKAL ARVKSMVQYP EARNQYRRLL NVVTEIQEKK 1020 VPYDDVMYTE GTVDFEDDLI DIEALLEDDT YMPTATQ*

Sequence ? help Back to Top

Protein Sequence Length: 1058 aa Download sequence Send to blast

MADSRRLGLA NQLDIEQILI EAQHRWLRPA EICEILQNYK KFRIAPEPAN MPPNGSLFLF  60
DRKVLRYFRK DGHNWRKKKD GKTVKEAHER LKAGSIDVLH CYYAHGEENE NFQRRSYWML  120
EEDLSHIVLV HYREVKGNRT NYNRIKETEE ADTAPSSEID SPASSSIPPN SYQMLSQTTD  180
TTSLNSAQAS EYEDAESAYN QASSRLHPFL ELQQPFAEKI NAGINDAYYP VSFSNNNQEK  240
LSAIPGMDSS AGVSSDHPKN LDFPAWDNTL GNNAASIHLP FQPAFSATQS NNLTAIQKQE  300
QEPFEQLFTN GFGKHPQIQE EWQASEGNSR LPKWPVDQTL LTGSDNNLTF RYQSEVASGD  360
ELLKVHRGNA EHDDFVKPVS KSNMNLEEKP YISGMKQPLL DGSFAEEGLK KLDSFNRWMS  420
KELGDVNESH MQTTSRAYWN SVESDTCVDD SSQVRLDNYV LSPSLSQEQL FSIIDFSPNW  480
AYESSEVKVL ITGRFLKVDQ AEMNKWSCMF GEVEVPAEII AEGVLRCNAP IHKVGRVPFY  540
VTCSNRLACS EVREFEYRLN EARDVQTKYN QSGCTNEILK LRFGKLMSLT STSSNANPVN  600
LAEMSQLSNK ISSLLKEDQD EWDQMFRLTS EENFSVERVQ EQLHQKLLKE KLHEWLLHKV  660
AEGGKGPSLL DEGGQGVLHF AAALGYDWAL EPTIVAGVSV NFRDANGWTA LHWAAFCGRE  720
RTVASLISLG AAPGLLTDPS PKYPSGKTPA DLASDNGHKG ISGYLAESAL SAHLKCLDLD  780
AKAGKTTDTS ILNAVQTVSE RTATPIKDGD PDRLSLKDSL AAVCNATQAA ARIHQVFRVQ  840
SFQRKQLEEF SDDKFGLSNE QALSLIAVKA QKSGRQNDDV NAAAIRIQNK FRGWKGRKDF  900
LNMRQNVVKI QAHVRGHQVR KNYKKFVWSV GIVEKIILRW RRKGSGLRGF KSEPVVEVPS  960
IQDQSSSKDD DYDFLKEGRK QSEQRMQKAL ARVKSMVQYP EARNQYRRLL NVVTEIQEKK  1020
VPYDDVMYTE GTVDFEDDLI DIEALLEDDT YMPTATQ*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2cxk_A	3e-14	473	558	9	89	calmodulin binding transcription activator 1
2cxk_B	3e-14	473	558	9	89	calmodulin binding transcription activator 1
2cxk_C	3e-14	473	558	9	89	calmodulin binding transcription activator 1
2cxk_D	3e-14	473	558	9	89	calmodulin binding transcription activator 1
2cxk_E	3e-14	473	558	9	89	calmodulin binding transcription activator 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3'. Binds calmodulin in a calcium-dependent manner in vitro (PubMed:12218065). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance in association with CAMTA1 and CAMTA2 (PubMed:23581962). Required for the cold-induced expression of DREB1B/CBF1, DREB1C/CBF2, ZAT12 and GOLS3 (PubMed:19270186). Involved in response to cold. Contributes together with CAMTA5 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2 (PubMed:28351986). Involved together with CAMTA2 and CAMTA4 in the positive regulation of a general stress response (GSR) (PubMed:25039701). Involved in the regulation of GSR amplitude downstream of MEKK1 (PubMed:25157030). Involved in the regulation of a set of genes involved in defense responses against pathogens (PubMed:18298954). Involved in the regulation of both basal resistance and systemic acquired resistance (SAR) (PubMed:21900483). Acts as negative regulator of plant immunity (PubMed:19122675, PubMed:21900483, PubMed:22345509, PubMed:28407487). Binds to the promoter of the defense-related gene EDS1 and represses its expression (PubMed:19122675). Binds to the promoter of the defense-related gene NDR1 and represses its expression (PubMed:22345509). Involved in defense against insects (PubMed:23072934, PubMed:22371088). Required for tolerance to the generalist herbivore Trichoplusia ni, and contributes to the positive regulation of genes associated with glucosinolate metabolism (PubMed:23072934). Required for tolerance to Bradysia impatiens larvae. Mediates herbivore-induced wound response (PubMed:22371088). Required for wound-induced jasmonate accumulation (PubMed:23072934, PubMed:22371088). Involved in the regulation of ethylene-induced senescence by binding to the promoter of the senescence-inducer gene EIN3 and repressing its expression (PubMed:22345509). {ECO:0000269\|PubMed:12218065, ECO:0000269\|PubMed:18298954, ECO:0000269\|PubMed:19122675, ECO:0000269\|PubMed:19270186, ECO:0000269\|PubMed:21900483, ECO:0000269\|PubMed:22345509, ECO:0000269\|PubMed:22371088, ECO:0000269\|PubMed:23072934, ECO:0000269\|PubMed:23581962, ECO:0000269\|PubMed:25039701, ECO:0000269\|PubMed:25157030, ECO:0000269\|PubMed:28351986, ECO:0000269\|PubMed:28407487, ECO:0000305\|PubMed:11925432}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00042	PBM	Transfer from AT2G22300	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By heat shock, UVB, salt, wounding, ethylene and methyl jasmonate (PubMed:11162426, PubMed:12218065). Induced by infection with the fungal pathogen Golovinomyces cichoracearum (powdery mildew) and the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000 (PubMed:22345509). {ECO:0000269\|PubMed:11162426, ECO:0000269\|PubMed:12218065, ECO:0000269\|PubMed:22345509}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024021686.1	0.0	calmodulin-binding transcription activator 3
Swissprot	Q8GSA7	0.0	CMTA3_ARATH; Calmodulin-binding transcription activator 3
TrEMBL	A0A2P5BFW1	0.0	A0A2P5BFW1_PARAD; Notch
STRING	XP_010087599.1	0.0	(Morus notabilis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF8284	27	35

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22300.2	0.0	signal responsive 1

Publications ? help Back to Top
Zhang L,Du L,Shen C,Yang Y,Poovaiah BW Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1/CAMTA3 signaling. Plant J., 2014. 78(2): p. 269-81 [PMID:24528504] Benn G, et al. A key general stress response motif is regulated non-uniformly by CAMTA transcription factors. Plant J., 2014. 80(1): p. 82-92 [PMID:25039701] Rahman H,Yang J,Xu YP,Munyampundu JP,Cai XZ Phylogeny of Plant CAMTAs and Role of AtCAMTAs in Nonhost Resistance to Xanthomonas oryzae pv. oryzae. Front Plant Sci, 2016. 7: p. 177 [PMID:26973658] Benn G, et al. Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(31): p. 8855-60 [PMID:27432993] Kidokoro S, et al. Different Cold-Signaling Pathways Function in the Responses to Rapid and Gradual Decreases in Temperature. Plant Cell, 2017. 29(4): p. 760-774 [PMID:28351986] Lolle S, et al. Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles. Cell Host Microbe, 2017. 21(4): p. 518-529.e4 [PMID:28407487] Kim YS, et al. CAMTA-Mediated Regulation of Salicylic Acid Immunity Pathway Genes in Arabidopsis Exposed to Low Temperature and Pathogen Infection. Plant Cell, 2017. 29(10): p. 2465-2477 [PMID:28982964] Jacob F, et al. A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana. New Phytol., 2018. 217(4): p. 1667-1680 [PMID:29226970]