PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G033034.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family MYB
Protein Properties Length: 304aa    MW: 34263.3 Da    PI: 5.7554
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G033034.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding43.76.6e-141156146
                          TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
       Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46
                          +g+W +eEde l++ vk++G+++W++I ++  + Rt+k+c++rw +
  HL.SW.v1.0.G033034.1 11 KGPWKAEEDEVLINHVKKYGPRDWSSIRSKGLLQRTGKSCRLRWVN 56
                          79*************************8887799**********87 PP
2Myb_DNA-binding41.72.6e-1367106344
                           SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
       Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 
                           +++ eE+   +++ +q+G++ W++Ia +++ gRt++++k++w
  HL.SW.v1.0.G033034.1  67 KFSLEEERVVIELQAQFGNK-WARIATYLP-GRTDNDVKNFW 106
                           799*****************.*********.*********** PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129421.061662IPR017930Myb domain
Gene3DG3DSA:1.10.10.602.2E-21759IPR009057Homeodomain-like
SuperFamilySSF466892.66E-288106IPR009057Homeodomain-like
SMARTSM007174.6E-111060IPR001005SANT/Myb domain
CDDcd001671.46E-111358No hitNo description
PfamPF139218.5E-131472No hitNo description
Gene3DG3DSA:1.10.10.601.0E-1760112IPR009057Homeodomain-like
PROSITE profilePS5129417.89563114IPR017930Myb domain
SMARTSM007179.7E-1264112IPR001005SANT/Myb domain
CDDcd001676.18E-1067106No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0048235Biological Processpollen sperm cell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 304 aa     Download sequence    Send to blast
MAGNREEGIR KGPWKAEEDE VLINHVKKYG PRDWSSIRSK GLLQRTGKSC RLRWVNKLRP  60
NLKNGCKFSL EEERVVIELQ AQFGNKWARI ATYLPGRTDN DVKNFWSSRQ KRLARILQSP  120
PTSSKSQKNK VEVSSDHEVP SFEARNISLS SEGESSSTAL QSSSSGIQNS ETIKMLPLPD  180
LVNPSKLFNF DQDLTHQAEF NTTENNLCNG SQPLITFPPA LQAQSDLTFS SESRDHLARF  240
SDPYFDMLSS VDSSKLGNVA DLDFGPPFLE PPETIRTGVV REKFDSEPDC FFDDFPIDMF  300
DHI*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1h8a_C4e-28911225126MYB TRANSFORMING PROTEIN
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269|PubMed:15618418, ECO:0000269|PubMed:15694308, ECO:0000269|PubMed:19300502, ECO:0000269|PubMed:21285328, ECO:0000269|PubMed:24876252}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:25057814}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015887610.11e-125transcription factor DUO1-like
SwissprotA0A178VEK74e-86DUO1_ARATH; Transcription factor DUO1
TrEMBLA0A2P5DAA11e-175A0A2P5DAA1_TREOI; MYB transcription factor
STRINGXP_008356546.11e-126(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36933164
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G60460.13e-83MYB family protein
Publications ? help Back to Top
  1. Zheng B,He H,Zheng Y,Wu W,McCormick S
    An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana.
    PLoS Genet., 2014. 10(7): p. e1004421
    [PMID:25057814]
  2. Peters B, et al.
    A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter.
    Plant Physiol., 2017. 173(1): p. 280-293
    [PMID:27624837]
  3. Zheng Z, et al.
    Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy.
    Plant Physiol., 2017. 174(3): p. 1764-1778
    [PMID:28515145]