PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kaladp0031s0012.1.p
Organism
Kalanchoe laxiflora
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family bHLH
Protein Properties Length: 627aa    MW: 67743 Da    PI: 4.9754
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kaladp0031s0012.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH36.87.1e-12454499454
                          HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                  HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                          +h e+Er RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI+ L
  Kaladp0031s0012.1.p 454 NHVEAERLRREKLNQKFYALRAVVPTV-----SKMDKASLLGDAISYINGL 499
                          799***********************6.....5***************988 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142159.3E-5247224IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.412450499IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.26E-17453527IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.108.3E-18454521IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.1E-9454499IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000835.65E-13454504No hitNo description
SMARTSM003538.2E-15456505IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 627 aa     Download sequence    Send to blast
MVNLWIDDAF QYDLSAFWPL PSSSSTTAHL DPPNPQLQNN PFTQESLHQR LLSLLDTTPT  60
QKWTYAIFWQ LSHSSTLGWG DGYYKGDDTK GQRRASDSTW LAEQDNRKKI LRELNSIISG  120
PGSVSLDDAV DEEVTDTEWF FLISMTQSFV NGDGLPGQAC LCSSPVWVVG EDLSSSSCER  180
ARQSRVFGIQ TMVCIPAVNG VVELGSTDLI FQSSDLMSRV RSLFHFEGFE SGNPWPVLSL  240
TGQDESGYDD QLAMLLTFSE PAQSLEMRDS GNGVGSSNHL APAPAAASSN VHVTDGNPSA  300
ASCVTENAGY KVDIPIGTPN LLEGQNFGSA GNADLLWVRP KSGENLSFGE ILKTSSSCGG  360
LVPDDDVAQF VASGGDGDKR RKSAASRQRK EEGVLSFTPS AGGPVLKPAV AVKCGEHYKG  420
SVKEADSSRV VEPEKKLPKK RGRKPANGRD EPINHVEAER LRREKLNQKF YALRAVVPTV  480
SKMDKASLLG DAISYINGLT AKLESLEADV QGLQGEVDSL KSVKMELSSP TGSNVSQEDG  540
GLKDLVLDVK IMGSDAMIRV QSSSKNHPAA ILMTALQQLS LDLQHASVSV VNNDLMIQQA  600
TIKMTSPCYT QEQLKLALSA RFRFSS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A1e-59422264194Transcription factor MYC3
4rqw_B1e-59422264194Transcription factor MYC3
4rs9_A1e-59422264194Transcription factor MYC3
4yz6_A1e-59422264194Transcription factor MYC3
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002280253.20.0PREDICTED: transcription factor MYC2
SwissprotA0A3Q7HRZ61e-174MYC2_SOLLC; Transcription factor MYC2
TrEMBLF6HT900.0F6HT90_VITVI; Uncharacterized protein
STRINGVIT_02s0012g01320.t010.0(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G17880.11e-119bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]