PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kaladp0081s0067.1.p
Organism
Kalanchoe laxiflora
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family bHLH
Protein Properties Length: 596aa    MW: 64754.7 Da    PI: 5.7106
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kaladp0081s0067.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.28.1e-10179224149
                          CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHH CS
                  HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAve 49 
                          +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i    +e
  Kaladp0081s0067.1.p 179 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGSIE 224
                          79***************************9...8888888888777666 PP
2HLH34.14.8e-11449500155
                          CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                  HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                          +r++h ++Er+RR+++N+ +  Lr+l+P +   + ++ + a+i    +e++++L+
  Kaladp0081s0067.1.p 449 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGSIEFVRELE 500
                          79****************************...9****************99985 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:4.10.280.101.6E-11177233IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000838.56E-11177234No hitNo description
SuperFamilySSF474592.22E-13178243IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088814.291178229IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.4E-7179224IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.7E-6184235IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.105.5E-13447503IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.22E-12447504No hitNo description
PROSITE profilePS5088815.008448499IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.09E-15448514IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.0E-8449500IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.7E-8454505IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 596 aa     Download sequence    Send to blast
MAPGAPAYAP VPEYSDQQQH MQQLMKARAP PFTVPQHRSQ GGPSSSPMVD YTLNNNFNHQ  60
QQEQNALLAG FSDVMQFADF GPKLGLNQSK MSSDDETGID PVYFLKFPVL NDKLEEEGGE  120
QLLGVGEGEP AGADQVGFEK SVVAAATAAP GDQAAAAASG KNKRKRGRAV KTSEEVESQR  180
MTHIAVERNR RKQMNEHLRV LRSLMPGSYV QRGDQASIIG GSIEFGRELE QLLQCLVSQK  240
RRRLYGDNPS NSNPATRQIG GGVMGDATTV TGLVQQQQQH PMMFPPPNCL SNVAGDHQTG  300
FDAAVDQEEE IAENKSCLAD VEVKVLGFDA MIKILSRRRP GQLIRTIAAL EDLKLVIMHT  360
NITTIEQSVL YSFNVKFPVL NDKLEEEGGE QLLGVGEGEP AGADQVGFEK SVVAAATAAP  420
GDQAAAAASG KNKRKRGRAV KTSEEVESQR MTHIAVERNR RKQMNEHLRV LRSLMPGSYV  480
QRGDQASIIG GSIEFVRELE QLLQCLESQK RRRLYGDNPS NSNPATRQIG GGVMGDATTV  540
TGLVQQQQQH PMMFPPPNCL SNVPGDRQTG FDAAVDQEEE IAENKACLSD GEVRC*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1449460RMTHIAVERNRR
2509513KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020534623.11e-121transcription factor FAMA isoform X2
RefseqXP_020534624.11e-121transcription factor FAMA isoform X2
RefseqXP_020534625.11e-121transcription factor FAMA isoform X3
SwissprotQ56YJ81e-105FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A067KT331e-120A0A067KT33_JATCU; Uncharacterized protein
STRINGcassava4.1_024031m1e-118(Manihot esculenta)
STRINGXP_002518108.11e-117(Ricinus communis)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.13e-78bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]