PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kaladp0095s0613.1.p
Organism
Kalanchoe laxiflora
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family E2F/DP
Protein Properties Length: 375aa    MW: 42137.4 Da    PI: 9.8383
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kaladp0095s0613.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.81.6e-222085171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rk+ksL+ll+++fl l++++  + v l+++a++L    v  +rRRiYDi+N+Le+++++++k+kn+++wkg
  Kaladp0095s0613.1.p 20 RKQKSLGLLCSNFLGLYNREGVQSVGLDDAANRL---GV--ERRRIYDIVNILESVGVLARKAKNQYTWKG 85
                         79*****************999************...**..****************************98 PP
2E2F_TDP77.41.4e-24154234171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          r+eksL+lltq+f+kl+ +s+ + ++l+++ak L+ +      +++k+RR+YDi+NVL ++nliek     ++k+++rw+g
  Kaladp0095s0613.1.p 154 RREKSLGLLTQNFIKLFLCSNMKLISLDDAAKLLLGDghgstIMRTKVRRLYDIANVLISMNLIEKthhteNRKPAFRWIG 234
                          689***************************************9************************999999******98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.6E-251686IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.22E-151983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.7E-272085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-192185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.1E-23150235IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.8E-34154234IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.09E-14156235IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.0E-19156234IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 375 aa     Download sequence    Send to blast
MAASSSILPE SGATQNAYSR KQKSLGLLCS NFLGLYNREG VQSVGLDDAA NRLGVERRRI  60
YDIVNILESV GVLARKAKNQ YTWKGFGAIP RALDELKVEG LKDNHSFSDG NDHGKQFSDD  120
EDERYSSQNS GSRPDKTNQV VTQNSSSSSK PDNRREKSLG LLTQNFIKLF LCSNMKLISL  180
DDAAKLLLGD GHGSTIMRTK VRRLYDIANV LISMNLIEKT HHTENRKPAF RWIGLRGKLE  240
NDSSTSLSKS NKRSFGTEIT NIDFKRSRLD SASVGKSMFG VKVQEPVQVK CESLGYEDEK  300
IMGHDSKVKT YEFGPFAPIN VSRVQTTENK PKQVHDWENL ATVYRPQYQN PALKELFGHY  360
KDAWHTWHSE VVKK*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-41192263228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015879579.11e-162E2F transcription factor-like E2FE isoform X2
RefseqXP_024924831.11e-162E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-121E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2I4FIR81e-154A0A2I4FIR8_JUGRE; E2F transcription factor-like E2FE
STRINGXP_004157798.11e-153(Cucumis sativus)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-106DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]