PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kaladp0095s0692.1.p
Organism
Kalanchoe laxiflora
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family E2F/DP
Protein Properties Length: 417aa    MW: 45968.7 Da    PI: 5.795
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kaladp0095s0692.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP78.27.5e-25157222171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++ ++++ ++ln  a+ L   +v  ++RRiYDi+NVLe+++liek++kn++rwkg
  Kaladp0095s0692.1.p 157 RYDSSLGLLTKKFINLIQGTKDRPLDLNYSAQVL---QV--QKRRIYDITNVLEGIGLIEKTSKNHVRWKG 222
                          6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.5E-26155223IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.86E-16157220IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.1E-30157222IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.6E-22159222IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146608.32E-32233340No hitNo description
SuperFamilySSF1440741.96E-25234339No hitNo description
PfamPF164212.9E-24238338IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 417 aa     Download sequence    Send to blast
MSSPISGERR PLPLPPPPQP SRYHYQALCP NQLPADAAKS APALPSPQLF HSDSRSPDSN  60
RKLTETSMNP VAISVGLRAG DGPCSVSDAR RFSTNHESHV AGYGGSNDRR PASNGPSVKP  120
DRSPPNKDQS KIKASKNTKN GNLKSENDYL NSAVSCRYDS SLGLLTKKFI NLIQGTKDRP  180
LDLNYSAQVL QVQKRRIYDI TNVLEGIGLI EKTSKNHVRW KGSNIMGEMD LDDEITMLKA  240
EMEQLCAMEC RLDARIREKQ ELLRAIDEDE NYNKYLFLTE NDITSLPCFQ NQTIVVVKAP  300
PASMVEVPDP DVQDFSGQQR QYRMIIRSTR GPIDLYLLSK VNGVPECVSV ESAQPMDASV  360
MDASSKKTEC AKQSSSSELP GITKIVPVES QSDDDYWFCS DPGISITDLW DTNGTA*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-20157222773PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010664799.11e-113PREDICTED: transcription factor E2FC isoform X2
SwissprotQ9FV702e-90E2FC_ARATH; Transcription factor E2FC
TrEMBLF6H0801e-111F6H080_VITVI; Uncharacterized protein
STRINGVIT_18s0001g14110.t011e-112(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.27e-93E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]