PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kalax.0043s0075.1.p
Organism
Kalanchoe marnieriana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family E2F/DP
Protein Properties Length: 467aa    MW: 51292.1 Da    PI: 4.9217
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kalax.0043s0075.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.93.1e-27137202171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++++e+g+++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Kalax.0043s0075.1.p 137 RYDSSLGLLTKKFINLIKHAEDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 202
                          6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-29134204IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.8E-34137202IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.08E-17137200IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.6E-24139202IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440744.18E-33215319No hitNo description
CDDcd146606.88E-49215319No hitNo description
PfamPF164211.9E-33218317IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 467 aa     Download sequence    Send to blast
MSGPRASNRS APAPPQPTKR HLPFTSIKPP FPAPAAADYH RFDGRKFGGQ DADAIVVRSP  60
QLKRKSMADD NEVASSNWTN STVYTEVDKS PLKKPVSAKG GRVYNKSKGS KGNKAAAQTP  120
LLTAGSPSAL TSAGNCRYDS SLGLLTKKFI NLIKHAEDGM LDLNKAAETL EVQKRRIYDI  180
TNVLEGIGLI EKKLKNRIRW KGLDVSQPDG VETDVSRLQI DVENLNLEEQ NLDDQIRGMQ  240
ERLRDLSEDE NNQKWLFVTE EDIKSLPCFQ NETLIAIKAP HGTTLEVPDP DEAANFPQRR  300
YRIVLRSTMG PIDVYLVSQF EEKFEDLNGA EQSVNCPVAS TSRPVENSGT RVANAQSTEN  360
DITGQAQDAH RVPSDTLMND NGSDDFVGGI MKIVPDVNAD TDYWFLSDAE LSVTELWHPE  420
SGIGNHLDDM PHHTDYEIGD TSIPQPQTPP SAVTDIPSSS VNSTSR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-23137203774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010654143.10.0PREDICTED: transcription factor E2FA isoform X2
SwissprotQ9FNY01e-152E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A438JAG60.0A0A438JAG6_VITVI; Transcription factor E2FA
TrEMBLD7TH520.0D7TH52_VITVI; Uncharacterized protein
STRINGVIT_08s0007g02510.t010.0(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-148E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]