PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Kalax.0085s0014.1.p

Organism

Kalanchoe marnieriana

Taxonomic ID

80907

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

E2F/DP

Protein Properties

Length: 436aa MW: 48917.3 Da PI: 9.6142

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0085s0014.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	55.1	1.3e-17	89	146	9	71
E2F_TDP 9 ltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 l+ +fl l++++ + v l+++a++L v +rRRiYDi+N+Le+++++++k+kn+++wkg Kalax.0085s0014.1.p 89 LSCSFLGLYNREGVQSVGLDDAANRL---GV--ERRRIYDIVNILESVGVLARKAKNQYTWKG 146 7889*****999********.....****************************98 PP
2	E2F_TDP	77	1.8e-24	215	295	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 r+eksL+lltq+f+kl+ +s+ + ++l+++ak L+ + +++k+RR+YDi+NVL ++nliek ++k+++rw+g Kalax.0085s0014.1.p 215 RREKSLGLLTQNFIKLFLCSNMKLISLDDAAKLLLGDghgstIMRTKVRRLYDIANVLISMNLIEKthhteNRKPAFRWIG 295 689*************************************9********************999999****98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	9.9E-16	87	146	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	8.2E-19	88	147	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	4.4E-15	88	146	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	3.5E-12	89	144	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	4.0E-23	211	296	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.8E-34	215	295	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.9E-19	217	295	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	6.25E-14	217	296	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 436 aa Download sequence Send to blast
MVGNVECELS RNEIDYTIKR KRISVTGKNG SVFVDSAGLG SYAERLQSEA EVTRPALLQV 60 ISIPLSTLSL LKFRSIERGP DLLLVSGFLS CSFLGLYNRE GVQSVGLDDA ANRLGVERRR 120 IYDIVNILES VGVLARKAKN QYTWKGFGAI PRALDELKVE GLKDNHSFSD GNDHGKQYSD 180 DEDERYSSQN SGSRPDKTNQ AVTQNSSSSS KPDNRREKSL GLLTQNFIKL FLCSNMKLIS 240 LDDAAKLLLG DGHGSTIMRT KVRRLYDIAN VLISMNLIEK THHTENRKPA FRWIGLRGKL 300 ENDSSTSLSK SNKRSFGTEI TNIDFKRSRL DSASVGKSMF GVKVQEPVQV KCESLGYEDE 360 KSMGHDSKVK TYEFGPFAPI NVSRVQTTEN KPKQVHDWEN LATVYRPQYQ NPALKELFGH 420 YKDAWHTWHS EVVKK*

Sequence ? help Back to Top

Protein Sequence Length: 436 aa Download sequence Send to blast

MVGNVECELS RNEIDYTIKR KRISVTGKNG SVFVDSAGLG SYAERLQSEA EVTRPALLQV  60
ISIPLSTLSL LKFRSIERGP DLLLVSGFLS CSFLGLYNRE GVQSVGLDDA ANRLGVERRR  120
IYDIVNILES VGVLARKAKN QYTWKGFGAI PRALDELKVE GLKDNHSFSD GNDHGKQYSD  180
DEDERYSSQN SGSRPDKTNQ AVTQNSSSSS KPDNRREKSL GLLTQNFIKL FLCSNMKLIS  240
LDDAAKLLLG DGHGSTIMRT KVRRLYDIAN VLISMNLIEK THHTENRKPA FRWIGLRGKL  300
ENDSSTSLSK SNKRSFGTEI TNIDFKRSRL DSASVGKSMF GVKVQEPVQV KCESLGYEDE  360
KSMGHDSKVK TYEFGPFAPI NVSRVQTTEN KPKQVHDWEN LATVYRPQYQ NPALKELFGH  420
YKDAWHTWHS EVVKK*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	5e-35	87	287	10	228	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015879579.1	1e-148	E2F transcription factor-like E2FE isoform X2
Refseq	XP_024924831.1	1e-148	E2F transcription factor-like E2FE isoform X2
Swissprot	Q8LSZ4	1e-110	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A1S3AW13	1e-143	A0A1S3AW13_CUCME; E2F transcription factor-like E2FE isoform X2
STRING	XP_004157798.1	1e-143	(Cucumis sativus)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	9e-99	DP-E2F-like 1

Link Out ? help Back to Top
Phytozome	Kalax.0085s0014.1.p

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]