PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Kalax.0141s0042.1.p

Organism

Kalanchoe marnieriana

Taxonomic ID

80907

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

E2F/DP

Protein Properties

Length: 417aa MW: 45963.7 Da PI: 6.0146

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0141s0042.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	78.2	7.5e-25	157	222	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++ ++++ ++ln a+ L +v ++RRiYDi+NVLe+++liek++kn++rwkg Kalax.0141s0042.1.p 157 RYDSSLGLLTKKFINLIQGTKDRPLDLNYSAQVL---QV--QKRRIYDITNVLEGIGLIEKTSKNHVRWKG 222 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.5E-26	155	223	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.86E-16	157	220	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.1E-30	157	222	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.6E-22	159	222	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	6.83E-32	233	340	No hit	No description
SuperFamily	SSF144074	1.96E-25	234	339	No hit	No description
Pfam	PF16421	7.4E-24	238	338	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 417 aa Download sequence Send to blast
MSSPISGERR PLPIPPPPQP SRFHYQALCP NQLPADAVKS APALPSPQLF HSDSRSPDSN 60 RKLTETSMNP VAISVGSRAG DGPCSVSDAR RFSTNHESHV AGYGGSNDRR PASNGPSVKP 120 DRSPPNKDQS KIKASKNTKN GNLKSENDYL NSAVSCRYDS SLGLLTKKFI NLIQGTKDRP 180 LDLNYSAQVL QVQKRRIYDI TNVLEGIGLI EKTSKNHVRW KGSNIMGEMD LDDEITMLKA 240 EMEHLCAMEC RLDARIREKQ ELLRAIDEDE NYNKYLFLTE NDITSLPCFQ NQTLVVVKAP 300 PASMVEVPDP DVQDFSGQQR QYRMIIRSTR GPIDLYLLSK VNGVPECVSV ESAQPMDASV 360 MDASSKKTEC AKQSSSSELP GITKIVPVES QSDDDYWFCS DPGISITDLW DTNGTA*

Sequence ? help Back to Top

Protein Sequence Length: 417 aa Download sequence Send to blast

MSSPISGERR PLPIPPPPQP SRFHYQALCP NQLPADAVKS APALPSPQLF HSDSRSPDSN  60
RKLTETSMNP VAISVGSRAG DGPCSVSDAR RFSTNHESHV AGYGGSNDRR PASNGPSVKP  120
DRSPPNKDQS KIKASKNTKN GNLKSENDYL NSAVSCRYDS SLGLLTKKFI NLIQGTKDRP  180
LDLNYSAQVL QVQKRRIYDI TNVLEGIGLI EKTSKNHVRW KGSNIMGEMD LDDEITMLKA  240
EMEHLCAMEC RLDARIREKQ ELLRAIDEDE NYNKYLFLTE NDITSLPCFQ NQTLVVVKAP  300
PASMVEVPDP DVQDFSGQQR QYRMIIRSTR GPIDLYLLSK VNGVPECVSV ESAQPMDASV  360
MDASSKKTEC AKQSSSSELP GITKIVPVES QSDDDYWFCS DPGISITDLW DTNGTA*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-20	157	222	7	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:16920782, ECO:0000269\|PubMed:19662336}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by light. {ECO:0000269\|PubMed:12468727, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010664799.1	1e-113	PREDICTED: transcription factor E2FC isoform X2
Swissprot	Q9FV70	7e-91	E2FC_ARATH; Transcription factor E2FC
TrEMBL	F6H080	1e-112	F6H080_VITVI; Uncharacterized protein
STRING	VIT_18s0001g14110.t01	1e-112	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G47870.2	4e-93	E2F/DP family protein

Link Out ? help Back to Top
Phytozome	Kalax.0141s0042.1.p

Publications ? help Back to Top
Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Huntley R, et al. The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins. Plant Mol. Biol., 1998. 37(1): p. 155-69 [PMID:9620273]