PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Kalax.0196s0092.1.p
Organism
Kalanchoe marnieriana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe
Family E2F/DP
Protein Properties Length: 361aa    MW: 39645.7 Da    PI: 9.755
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Kalax.0196s0092.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.74e-231580171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rk+ksL+ll+++fl l+ + +   + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Kalax.0196s0092.1.p 15 RKQKSLGLLCSNFLGLYDRDDVHSIGLDDAASKL---GV--ERRRIYDIVNVLESVGMLARKAKNQYSWKG 80
                         79****************9999************...**..****************************98 PP
2E2F_TDP75.74.7e-24144224171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          r+eksL+lltq+f+kl+ +s+ g ++l+++ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Kalax.0196s0092.1.p 144 RREKSLGLLTQNFIKLFVCSNVGLISLDDAAKVLLGDghnstVMRTKVRRLYDIANVLSSVNLIEKtqhkeSRKPAFRWLG 224
                          689**************************************999**********************999988999999987 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.3E-241381IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.91E-151478IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.9E-271580IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.1E-201680IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.8E-23139225IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.2E-32144224IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.59E-13146225IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023195.7E-20146224IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 361 aa     Download sequence    Send to blast
MAVAESGSGG SVYSRKQKSL GLLCSNFLGL YDRDDVHSIG LDDAASKLGV ERRRIYDIVN  60
VLESVGMLAR KAKNQYSWKG FGAIPRALQE LREEGVKESF GGSQGSIQIK VSDDEDDSYW  120
NSNNGSQPDK ANPSSASSKS ADNRREKSLG LLTQNFIKLF VCSNVGLISL DDAAKVLLGD  180
GHNSTVMRTK VRRLYDIANV LSSVNLIEKT QHKESRKPAF RWLGPGGKRE NGSATPPATQ  240
IELKKRTFGT EISNIDFKRA KVDPPVGIKP VKTQAAPPVK TESLEYDSDR SAKGYQFGPF  300
APAKTPAPAS EAPAKRMFDF ERLAPVYRPQ YQNQALKELF GHYVEAWHSW YAEVVGTPLN  360
*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-41142163228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015879579.11e-157E2F transcription factor-like E2FE isoform X2
RefseqXP_024924831.11e-157E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-123E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2I4FIR81e-151A0A2I4FIR8_JUGRE; E2F transcription factor-like E2FE
STRINGXP_010678681.11e-145(Beta vulgaris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-120DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]