PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Kalax.0217s0004.1.p

Organism

Kalanchoe marnieriana

Taxonomic ID

80907

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Saxifragales; Crassulaceae; Kalanchoe

Family

NAC

Protein Properties

Length: 448aa MW: 49588.4 Da PI: 4.9272

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Kalax.0217s0004.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	107.3	1.9e-33	59	198	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk......lelee.....vikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk 79 lp+G++F+Ptd+e++ ++L +k+ + + + v ke +i++++P++Lp vk++ + +fF+++ k+y+tg+rk+r+++ Kalax.0217s0004.1.p 59 LPRGVKFDPTDQEII-HHLLAKCGIGNlkahpfI---NefiptVNKEDGICYTHPQNLP-GVKQDGSVAHFFHRAIKAYNTGSRKRRKIQ 143 799**********.666666666663454332...133331233336******.677888899**************855 PP NAM 80 .....sgyWkatgkdkevlskkgelvglkktLvfy..kgrapkgektdWvmheyrl 128 + +W++tg++k+v+ +g ++g+kk++v+y ++ k+ekt+Wvmh+y+l Kalax.0217s0004.1.p 144 gdssgDVRWHKTGRTKPVML-DGVQKGCKKIMVLYisPAKGGKAEKTNWVMHQYHL 198 55544778********.99********5534667778*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.01E-39	44	217	IPR003441	NAC domain
PROSITE profile	PS51005	31.822	59	217	IPR003441	NAC domain
Pfam	PF02365	2.7E-14	60	198	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 448 aa Download sequence Send to blast
MSTGPTWLVD GHRIATKIKS AAGASDLGHM KWKSNPCRAC PNCQYIIDNS DVPQDWPGLP 60 RGVKFDPTDQ EIIHHLLAKC GIGNLKAHPF INEFIPTVNK EDGICYTHPQ NLPGVKQDGS 120 VAHFFHRAIK AYNTGSRKRR KIQGDSSGDV RWHKTGRTKP VMLDGVQKGC KKIMVLYISP 180 AKGGKAEKTN WVMHQYHLGT EEDEKDGECV ISKIFYQQQP GKASDGVEQE ISETSYTAVA 240 KVDPVTPRSA IPLPPRTEAR DSDLELVEVS ALTQMEPLHQ GLDTDYTGDL DEQNESEAIK 300 IQDQPRADGH SGEGDAVENN DNPAAEDPSW WEESPFLLSS QQLAEGLAIC DDLLQSQSPG 360 RQGFANPQES KGRPRLADYS QLGPENLKKD LEECQTLEFD PTKIELDALL ELHLSQDIRL 420 SQDFRLSQLE FCSQDSFCAF GGNKVID*

Sequence ? help Back to Top

Protein Sequence Length: 448 aa Download sequence Send to blast

MSTGPTWLVD GHRIATKIKS AAGASDLGHM KWKSNPCRAC PNCQYIIDNS DVPQDWPGLP  60
RGVKFDPTDQ EIIHHLLAKC GIGNLKAHPF INEFIPTVNK EDGICYTHPQ NLPGVKQDGS  120
VAHFFHRAIK AYNTGSRKRR KIQGDSSGDV RWHKTGRTKP VMLDGVQKGC KKIMVLYISP  180
AKGGKAEKTN WVMHQYHLGT EEDEKDGECV ISKIFYQQQP GKASDGVEQE ISETSYTAVA  240
KVDPVTPRSA IPLPPRTEAR DSDLELVEVS ALTQMEPLHQ GLDTDYTGDL DEQNESEAIK  300
IQDQPRADGH SGEGDAVENN DNPAAEDPSW WEESPFLLSS QQLAEGLAIC DDLLQSQSPG  360
RQGFANPQES KGRPRLADYS QLGPENLKKD LEECQTLEFD PTKIELDALL ELHLSQDIRL  420
SQDFRLSQLE FCSQDSFCAF GGNKVID*

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_002281522.1	0.0	PREDICTED: NAC domain-containing protein 8 isoform X1
Refseq	XP_010647959.1	0.0	PREDICTED: NAC domain-containing protein 8 isoform X1
Swissprot	Q6NQK2	1e-157	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A1J0A0N5	0.0	A0A1J0A0N5_RHOML; NAC
STRING	VIT_01s0011g02990.t01	0.0	(Vitis vinifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G25580.1	1e-160	NAC family protein

Link Out ? help Back to Top
Phytozome	Kalax.0217s0004.1.p

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]